Stage dependent nutritional regulation of transgenerational longevity

Roussou, Ilianna G.; Savakis, Charalambos; Tavernarakis, Nektarios; Metaxakis, Athanasios

doi:10.3233/nha-160012

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…In Drosophila, environmentally induced phenotypes that depend on epigenetic regulation involve transmission across several generations [74][75][76] . C. elegans has been shown to translate several environmental stimuli, such as viral infection, starvation or elevated temperatures, into modification of epigenetic components [77][78][79] .…”

Section: Environmental Epigenetic Regulation In Animalsmentioning

confidence: 99%

Advances in epigenetics link genetics to the environment and disease

Cavalli

Heard

2019

Nature

931

696

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Epigenetic research has accelerated rapidly in the twenty-first century, generating justified excitement and hope, but also a degree of hype. Here we review how the field has evolved over the last few decades and reflect on some of the recent advances that are changing our understanding of biology. We discuss the interplay between epigenetics and DNA sequence variation as well as the implications of epigenetics for cellular memory and plasticity. We consider the effects of the environment and both intergenerational and transgenerational epigenetic inheritance on biology, disease and evolution. Finally, we present some new frontiers in epigenetics with implications for human health.

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Section: Environmental Epigenetic Regulation In Animalsmentioning

confidence: 99%

Advances in epigenetics link genetics to the environment and disease

Cavalli

Heard

2019

Nature

931

696

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“…Here we explore the PAR hypothesis and the ability of nutrition to affect gene expression at a whole-genome level by manipulating the diet of the fruitfly, Drosophila melanogaster, to investigate the extent to which gene expression is changed by differing levels of macronutrients. Previous research has shown that a high-sugar maternal diet can alter the body composition of larval Drosophila offspring for at least two generations (Buescher et al, 2013), as well as demonstrating that nutrition is able to influence traits relative to metabolic syndrome, longevity and the immune response (Musselman et al, 2011, Morgan, 2012, Roussou et al, 2016). Considering such traits and responses are often under epigenetic control, we predict that dietary manipulation will have broad consequences for the expression of genes involved in epigenetic processes.…”

Section: Introductionmentioning

confidence: 99%

A ‘phenotypic hangover’ – the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome of Drosophila melanogaster

Osborne

Dearden

2017

Preprint

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The Developmental Origins of Health and Disease (DOHaD) hypothesis predicts that early-life environmental exposures can be detrimental to later-life health, and that mismatch between the pre- and postnatal environment may contribute to the growing non-communicable disease (NCD) epidemic. Within this is an increasingly recognised role for epigenetic mechanisms; epigenetic modifications can be influenced by, e.g., nutrition, and can alter gene expression in mothers and offspring. Currently, there are no whole-genome transcriptional studies of response to nutritional alteration. Thus, we sought to explore how nutrition affects the expression of genes involved in epigenetic processes in Drosophila melanogaster. We manipulated Drosophila food macronutrient composition at the F0 generation, mismatched F1 offspring back to a standard diet, and analysed the transcriptome of the F0 – F3 generations by RNA-sequencing. At F0, the altered (high protein, low carbohydrate, HPLC) diet increased expression of genes involved in epigenetic processes, with coordinated downregulation of genes involved in immunity, neurotransmission and neurodevelopment, oxidative stress and metabolism. Upon reversion to standard nutrition, mismatched F1 and F2 generations displayed multigenerational inheritance of altered gene expression. By the F3 generation, gene expression had reverted to F0 (matched) levels. These nutritionally-induced gene expression changes demonstrate that dietary alteration can upregulate epigenetic genes, which may influence the expression of genes with broad biological functions. Further, the multigenerational inheritance of the gene expression changes in F1 and F2 mismatched generations suggests a predictive adaptive response (PAR) to maternal nutrition. Our findings may help to understand the interaction between maternal diet and future offspring health, and have direct implications for the current NCD epidemic.

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“…Finally, tissue-specific and time-dependent genetic manipulations may be readily achievable for most genes, for instance, using the 22,270 transgenic lines (currently, covering ~88% of all predicted protein-coding genes) from the Vienna Drosophila Resource Center [73]. Therefore, Drosophila is well-suited for both correlational and mechanistic studies focusing on transgenerational programming of longevity after nutritional or environmental manipulations in the F0 parents [74][75][76][77].…”

Section: Agingmentioning

confidence: 99%

“…A more recent study has demonstrated that distinct dietary manipulations in the larval stage or throughout adulthood may also induce transgenerational programming of longevity [75].…”

Section: Agingmentioning

confidence: 99%

Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila

Xia¹,

Belle²

2018

Drosophila Melanogaster - Model for Recent Advances in Genetics and Therapeutics

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It is increasingly recognized that acquired traits may be transgenerationally transmitted through non-DNA sequence-based elements, with epigenetics as perhaps the most important mechanism. Here we review examples of non-genetic transgenerational inheritance in Drosophila, highlighting transgenerational programming of metabolic status and longevity, one particular histone modification as an evolutionarily conserved underlying mechanism, and important implications of such studies in understanding health and diseases.

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Stage dependent nutritional regulation of transgenerational longevity

Cited by 8 publications

References 24 publications

Advances in epigenetics link genetics to the environment and disease

Advances in epigenetics link genetics to the environment and disease

A ‘phenotypic hangover’ – the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome of Drosophila melanogaster

Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila

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