Stadieneinteilung der malignen Lymphome

Musshoff, K.; Slanina, J

doi:10.1007/bf01620747

Cited by 36 publications

(37 citation statements)

References 14 publications

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“…The histopathologic characteristics of all tumor specimens were independently reviewed by two expert hematopathologists. Staging was based on Musshoff's modification of the Ann Arbor staging system [22] . Staging procedures included physical examination, routine laboratory tests, inspection of Waldeyer's ring, chest radiography, chest and abdominal CT scan, bone marrow aspiration, and trephine biopsy.…”

Section: Patients Treatment and Evaluation Of The Tumorsmentioning

confidence: 99%

Expression of CD86 and increased infiltration of NK cells are associated withHelicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

Kuo

Chen

Chen³

et al. 2005

WJG

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Abstract Abstract AbstractAIM: A high percentage of early-stage high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori (H pylori)-dependent. However, unlike their low-grade counterparts, high-grade gastric MALT lymphomas may progress rapidly if unresponsive to H pylori eradication. It is mandatory to identify markers that may predict the H pylori-dependent status of these tumors. Proliferation of MALT lymphoma cells depends on cognate help and cell-to-cell contact of H pylori-specific intratumoral T-cells. To examine whether the expression of co-stimulatory marker CD86 (B7.2) and the infiltration of CD56 (+) natural killer (NK) cells can be useful markers to predict H pylori-dependent status of high-grade gastric MALT lymphoma. METHODS:Lymphoma biopsies from 26 patients who had participated in a prospective study of H pylori-eradication for stage I E high-grade gastric MALT lymphomas were evaluated. Tumors that resolved to Wotherspoon grade II or less after H pylori eradication were classified as H pyloridependent; others were classified as H pylori-independent. The infiltration of NK cells and the expression of CD86 in pre-treatment paraffin-embedded lymphoma tissues were determined by immunohistochemistry. RESULTS:There were 16 H pylori-dependent and 10 H pylori-independent cases. CD86 expression was detected in 11 (68.8%) of 16 H pylori-dependent cases but in none of 10 H pylori-independent cases (P = 0.001). H pylori-dependent high-grade gastric MALT lymphomas contained significantly higher numbers of CD56 (+) NK cells than H pylori-independent cases (2.8±1.4% vs 1.1±0.8%; P = 0.003). CD86 positive MALT lymphomas also showed significantly increased infiltration of CD56 (+) NK cells compared to CD86-negative cases (2.9±1.1% vs 1.4±1.3%; P = 0.005). CONCLUSION:These results suggest that the expression of co-stimulatory marker CD86 and the increased infiltration of NK cells are associated with H pylori-dependent state of early-stage high-grade gastric MALT lymphomas.

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Section: Patients Treatment and Evaluation Of The Tumorsmentioning

confidence: 99%

Expression of CD86 and increased infiltration of NK cells are associated withHelicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

Kuo

Chen

Chen³

et al. 2005

WJG

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“…Staging of disease was assigned according to an adaptation of the Ann Arbor staging system for extranodal lymphomas. 31 …”

Section: Tissue and Clinical Datamentioning

confidence: 99%

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

Inagaki

Chan

et al. 2002

The American Journal of Pathology

101

106

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Extranodal marginal-zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT) arising in the thymus is rare, with the largest series in the literature including only three cases. In the present study, we investigated 15 cases of thymic MALT lymphoma to systematically characterize its clinical, histopathological, and molecular features. There was a marked female predilection (male:female ‫؍‬ 1:4), with a mean age of 55 years at diagnosis. There was a strong association with autoimmune disease, especially Sjögren's syndrome.

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“…Patients were staged according to the Ann Arbor classification 31 with modifications for extranodal lymphoma. 32 For adequate staging at least a chest radiograph and/or CT scan, a CT scan of the abdomen or lymphangiogram supplemented by isotope spleen and liver scan in the early years of registration, and a bone marrow biopsy had to be performed. In addition to clinical stage, the presence or absence of lymphoma at various anatomical sites was recorded.…”

Section: Patients and Materialsmentioning

confidence: 99%

CD44 expression predicts disease outcome in localized large B cell lymphoma

et al. 1999

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Diffuse large B cell non-Hodgkin's lymphomas (DLCL) form a heterogeneous group of tumors with diverse morphology, clinical features, treatment response and prognosis. The biological variables underlying this heterogeneity are unknown. In the present study, we explored the value of the lymphocyte homing receptor CD44, a putative determinant of lymphoma dissemination, in predicting prognosis in DLCL. Expression of the standard form of CD44 (CD44s) and of CD44 isoforms containing exon v6 (CD44v6) on tumor cells was assessed by immunohistochemistry in a cohort of 276 DLCL patients from a population based lymphoma registry. We observed that CD44s as well as CD44v6 expression correlated with tumor dissemination in patients with primary nodal DLCL. Importantly, in patients with localized nodal disease, CD44s was a strong prognosticator predicting tumor related death independent of the other parameters of the International Prognostic Index (IPI). Incorporation of CD44s in the IPI parameter 'stage', increased the prognostic value of this parameter in nodal DLCL. Our data identify CD44 as a biological prognosticator, which can be used to 'finetune' the IPI for nodal DLCL.

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Stadieneinteilung der malignen Lymphome

Cited by 36 publications

References 14 publications

Expression of CD86 and increased infiltration of NK cells are associated withHelicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

Expression of CD86 and increased infiltration of NK cells are associated withHelicobacter pylori-dependent state of early stage high-grade gastric MALT lymphoma

Primary Thymic Extranodal Marginal-Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type Exhibits Distinctive Clinicopathological and Molecular Features

CD44 expression predicts disease outcome in localized large B cell lymphoma

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