Stachyose in combination with L. rhamnosus GG ameliorates acute hypobaric hypoxia-induced intestinal barrier dysfunction through alleviating inflammatory response and oxidative stress

Ren, Dingxin; Ding, Mengying; Su, Junqing; Ye, Jianzhou; He, Xiaoqin; Zhang, Yafeng; Shang, Xiaoya

doi:10.1016/j.freeradbiomed.2024.01.009

Cited by 5 publications

(2 citation statements)

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“…Dou et al [17] found that bio-selenium nanoparticles synthesized by Lactobacillus casei could upregulate ZO-1 and Occludin content reduced by hypoxia, decrease DAO content in the ileum, and protect the intestinal barrier function. Treatment with LGG combined with sucrose also increased the expression of ZO-1 and occludin in the ileum [26]. This suggests that Lactobacillus intervention can protect the intestinal barrier by upregulating tight junction proteins in the ileum, reducing harmful substance leakage from the small intestine, and playing a role in lowering inflammation levels.…”

Section: Discussionmentioning

confidence: 78%

“…Hypoxia also has a profound and lasting impact on the gut microbiota [8], and dysbiosis of the gut microbiota can further exacerbate damage to the intestinal barrier [25]. Numerous studies have demonstrated that probiotics or prebiotics can improve intestinal barrier dysfunction caused by hypoxic exposure and reduce inflammatory responses [19,26]. Therefore, this study sought to explore whether lactic acid bacteria, commonly used in everyday life, have the potential to mitigate acute damage induced by hypoxia.…”

Section: Discussionmentioning

confidence: 99%

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Lactobacillus delbrueckii subsp. bulgaricus Alleviates Acute Injury in Hypoxic Mice

Song,

Ling,

Wang

et al. 2024

Nutrients

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Acute mountain sickness (AMS) is a common ailment in high-altitude areas caused by the body’s inadequate adaptation to low-pressure, low-oxygen environments, leading to organ edema, oxidative stress, and impaired intestinal barrier function. The gastrointestinal tract, being the first to be affected by ischemia and hypoxia, is highly susceptible to injury. This study investigates the role of Lactobacillus delbrueckii subsp. bulgaricus in alleviating acute hypoxic-induced intestinal and tissue damage from the perspective of daily consumed lactic acid bacteria. An acute hypoxia mouse model was established to evaluate tissue injury, oxidative stress, inflammatory responses, and intestinal barrier function in various groups of mice. The results indicate that strain 4L3 significantly mitigated brain and lung edema caused by hypoxia, improved colonic tissue damage, and effectively increased the content of tight junction proteins in the ileum, reducing ileal permeability and alleviating mechanical barrier damage in the intestines due to acute hypoxia. Additionally, 4L3 helped to rebalance the intestinal microbiota. In summary, this study found that Lactobacillus delbrueckii subsp. bulgaricus strain 4L3 could alleviate acute intestinal damage caused by hypoxia, thereby reducing hypoxic stress. This suggests that probiotic lactic acid bacteria that exert beneficial effects in the intestines may alleviate acute injury under hypoxic conditions in mice, offering new insights for the prevention and treatment of AMS.

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Section: Discussionmentioning

confidence: 78%