Stachydrine Suppresses Viability &amp; Migration of Astrocytoma Cells Via CXCR4/ERK &amp; CXCR4/Akt Pathway Activity

Liu, Yun; Wei, Songzhi; Zou, Qin; Luo, Yan

doi:10.2217/fon-2017-0562

Cited by 17 publications

(19 citation statements)

References 52 publications

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“…Indeed, adequate literature support exists on stachydrine, trigonelline, and the glucosinolate breakdown products. In vitro and in vivo studies show that stachydrine exhibits inhibition of the NF-κB signalling pathways [34,71,72]. Likewise, trigonelline showed antidiabetic effects and counteracted insulin resistance by suppressing inflammation [34,73].…”

Section: Discussionmentioning

confidence: 99%

“…Especially, Brassica vegetables are known for their preventive role against these inflammation related disorders, mainly due to their glucosinolate content. Glucosinolate hydrolysis products, the isothiocyanates, are known to play important roles in disease prevention by triggering antioxidant and anti-inflammatory responses, among others [31][32][33][34]. In our previous work, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) mediated antioxidant effect of M. subcordata different extracts and the presence, in these extracts, of phytochemicals such as glucosinolates was reported [35].…”

Section: Introductionmentioning

confidence: 99%

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Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Hiben

Haan

Spenkelink

et al. 2020

BMC Complement Med Ther

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Background: The health benefits of botanicals is linked to their phytochemicals that often exert pleiotropic effects via targeting multiple molecular signaling pathways such as the peroxisome proliferator-activated receptors (PPARs) and the nuclear factor kappaB (NFκB). The PPARs are transcription factors that control metabolic homeostasis and inflammation while the NF-κB is a master regulator of inflammatory genes such as the inducible nitric-oxide synthase that result in nitric oxide (NO) overproduction. Methods: Extracts of Maerua subcordata (MS) and selected candidate constituents thereof, identified by liquid chromatography coupled to mass spectroscopy, were tested for their ability to induce PPARγ mediated gene expression in U2OS-PPARγ cells using luciferase reporter gene assay and also for their ability to inhibit lipopolysaccharide (LPS) induced NO production in RAW264.7 macrophages. While measuring the effect of test samples on PPARγ mediated gene expression, a counter assay that used U2OS-Cytotox cells was performed to monitor cytotoxicity or any non-specific changes in luciferase activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Hiben

Haan

Spenkelink

et al. 2020

BMC Complement Med Ther

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“…Stachydrine (STA), a bioactive constituent extracted from a medicinal herb Leonurus heterophyllus Sweet, has extensive pharmacological properties, including antioxidant, anti‐inflammatory, anticancer and cardioprotective properties . Recent studies have reported that STA inhibits NF‐κB and MAPK pathways in different cell types . As the NF‐κB and MAPK pathways are crucial for osteoclastogenesis and because STA exerts inhibitory effects on these pathways, we hypothesized that STA may represent a novel candidate for treating osteoclast‐related diseases by inducing the targeted suppression of osteoclastogenesis.…”

Section: Introductionmentioning

confidence: 99%

“…[17][18][19][20] Recent studies have reported that STA inhibits NF-κB and MAPK pathways in different cell types. [20][21][22] As the NF-κB and MAPK pathways are crucial for osteoclastogenesis and because STA exerts inhibitory effects on these pathways, we hypothesized that STA may represent a novel candidate for treating osteoclast-related diseases by inducing the targeted suppression of osteoclastogenesis.…”

mentioning

confidence: 99%

Stachydrine prevents LPS‐induced bone loss by inhibiting osteoclastogenesis via NF‐κB and Akt signalling

Meng

Zhou

Zhang

et al. 2019

J Cellular Molecular Medi

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Osteoclast overactivation‐induced imbalance in bone remodelling leads to pathological bone destruction, which is a characteristic of many osteolytic diseases such as rheumatoid arthritis, osteoporosis, periprosthetic osteolysis and periodontitis. Natural compounds that suppress osteoclast formation and function have therapeutic potential for treating these diseases. Stachydrine (STA) is a bioactive alkaloid isolated from Leonurus heterophyllus Sweet and possesses antioxidant, anti‐inflammatory, anticancer and cardioprotective properties. However, its effects on osteoclast formation and function have been rarely described. In the present study, we found that STA suppressed receptor activator of nuclear factor‐κB (NF‐κB) ligand (RANKL)‐induced osteoclast formation and bone resorption, and reduced osteoclast‐related gene expression in vitro. Mechanistically, STA inhibited RANKL‐induced activation of NF‐κB and Akt signalling, thus suppressing nuclear factor of activated T cells c1 induction and nuclear translocation. In addition, STA alleviated bone loss and reduced osteoclast number in a murine model of LPS‐induced inflammatory bone loss. STA also inhibited the activities of NF‐κB and NFATc1 in vivo. Together, these results suggest that STA effectively inhibits osteoclastogenesis both in vitro and in vivo and therefore is a potential option for treating osteoclast‐related diseases.

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“…It was accounted for that stachydrine strongly affects provocative pathway [67]. Stachydrine stifles practicality and movement of astrocytoma cells by means of CXCR4/ERK and CXCR4/Akt pathway action [68]. Stachydrine ensures eNOS uncoupling and improves endothelial brokenness instigated by homocysteine [69].…”

Section: Heterocyclic Alkaloids or Typical Alkaloidsmentioning

confidence: 99%

Chemistry of Secondary Metabolites

Mohiuddin¹

2019

ACT

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Medicinal plants, are known to deliver a wide scope of Plant Secondary Metabolites (PSMs) connected as bug sprays, medications, colors and poisons in farming, prescription, industry and biofighting in addition to bio-fear mongering, separately. Be that as it may, creation of PSMs is for the most part in little amounts, so we have to discover novel approaches to increment both amount and nature of them. Luckily, biotechnology proposes a few choices through which secondary metabolism in plants can be built in imaginative approaches to: 1) over-produce the valuable metabolites, 2) down-produce the poisonous metabolites, 3) produce the new metabolites. Secondary metabolites are extensively characterized as natural products integrated by a life form that is not basic to help development and life. The plant kingdom fabricates more than 200,000 unmistakable chemical compounds, a large portion of which emerge from particular metabolism. While these compounds assume critical jobs in interspecies challenge and safeguard, many plant natural products have been abused for use as prescriptions, scents, flavors, supplements, repellants, and colorants. In spite of this immense chemical decent variety, numerous secondary metabolites are available at low focuses in plant a, taking out yield based assembling as methods for achieving these imperative products. The basic and stereo chemical unpredictability of particular metabolites frustrates most endeavors to get to these compounds utilizing chemical blend. Albeit local plants can be built in amass target pathway metabolites. This Update gives a concise outline of designing plant secondary metabolism in microbial frameworks. We quickly diagram biosynthetic pathways intervening arrangement of the real classes of natural products with an accentuation on high-esteem terpenoids, alkaloids, phenylpropanoids, and polyketides. We additionally feature basic topics, techniques, and provoke hidden endeavors to reproduce and build these pathways in microbial hosts. We center mostly around again biosynthetic methodologies in which plant specific metabolites are combined straightforwardly from sugar feed stocks instead of enhanced forerunners or intermediates.

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Stachydrine Suppresses Viability & Migration of Astrocytoma Cells Via CXCR4/ERK & CXCR4/Akt Pathway Activity

Cited by 17 publications

References 52 publications

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Stachydrine prevents LPS‐induced bone loss by inhibiting osteoclastogenesis via NF‐κB and Akt signalling

Chemistry of Secondary Metabolites

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