Stable twisted conformation aza-BODIPY NIR-II fluorescent nanoparticles with ultra-large Stokes shift for imaging-guided phototherapy

Abstract

Fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) holds great promise for in vivo imaging and imaging-guided phototherapy with deep penetration and high spatiotemporal resolution. It is very...

Attachment of −tBu groups to aza-BODIPY core at 3,5-sites with ultra-large Stokes shift to enhance photothermal therapy through apoptosis mechanism

“…S4 , the electron density of HOMO mainly distributes on the non- t Bu groups, whereas the LUMO mainly concentrates on the BODIPY core. The different location of HOMO and LUMO results in the transition between them, undergoing a TICT process, which usually leads to a weak fluorescence and an ultra-large Stokes shift [ 54 , 55 ]. Moreover, the rotational process between SMe-tBuazaBDP and SMe-PhazaBDP are compared, as shown in Fig.…”

Recent theranostic applications of hydrogen peroxide-responsive nanomaterials for multiple diseases

“…34–36 Furthermore, H 2 O 2 -related diagnosis based on H 2 O 2 -responsive nanomaterials holds promise for the diagnosis of multiple diseases via medical imaging technology like fluorescent imaging (FLI), photoacoustic imaging (PAI), ultrasound (US) imaging, and magnetic resonance imaging (MRI). 37–40 For example, the catalytic decomposition of H 2 O 2 produces O 2 bubbles that reflect ultrasound signals in US imaging. 41 Another example, the conversion of ABTS into oxidized ABTS in the presence of H 2 O 2 leads to strong near-infrared (NIR) absorbance, thus used for PA imaging.…”

Aza-BODIPY with two efficacious fragments for NIR light-driven photothermal therapy by triggering cancer cell apoptosis

“…Aza-BODIPY derivatives are known to be extensively employed in fluorescence imaging, phototherapy, photocatalysis, and others. [37][38][39][40][41] For blocking fluorescence, inducing intersystem crossing (ISC), and enhancing photothermal conversion, the skillful structural design of aza-BODIPYs is required, including photoinduced electron transfer (PET), 42,43 intramolecular charge transfer (ICT), 44,45 twisted intramolecular charge transfer (TICT), [46][47][48] or a rotor with the freely rotating groups. 49 Our group recently discovered that aza-BODIPY with tert-butyl groups at 1,7-or 3,5-sites is a novel molecule, and the rotating tert-butyl group caused non-radiative heat production in excited states, which is an intriguing approach for designing photothermal reagents (Fig.…”