Stable Trough Levels but Significant Reduction of the Area Under the Curve of Tacrolimus in Renal Transplanted Patients Converted From Associated Mycophenolate Mofetil to Equimolar Doses of Enteric-Coated Mycophenolate Sodium
Abstract:the patients were still on MMF and 70% on steroids. In the four arms, the mean GFR change over the 2nd and 3rd year was between +1 and -3 ml/min. At 3 years, the low-dose tacrolimus arm still had the highest GFR, although the difference was not signifi cant (68 vs 62-65 ml/min, p = 0.10). Over the 2nd and 3rd years all arms had low rates of biopsy-proven acute rejection (BPAR; 1-3%) and graft loss (3-6%). Non-fatal cardiovascular events were rare (42 cases in total until month 36): 5.2% in the standard-dose Cs… Show more
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