Stable, triplet ground state BODIPY-TEMPO diradical as a selective turn on fluorescence sensor for intracellular labile iron pool

Pachpatil, Pradnya K.; Kanojia, Seema V.; Ghosh, Ayan; Majumdar, Ananda G.; Wadawale, Amey; Mohapatra, M.; Patro, Birija Sankar; Ghanty, Tapan K.; Goswami, Dibakar

doi:10.1016/j.snb.2022.132474

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Robust radicals also have various other applications, such as sensors, ,, actuators, electrocatalysis, and recently desalination.…”

Section: Application Of Organic Radicals In Energy Conversion/storage...mentioning

confidence: 99%

Redox: Organic Robust Radicals and Their Polymers for Energy Conversion/Storage Devices

Hatakeyama-Sato,

Oyaizu

2023

Chem. Rev.

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Persistent radicals can hold their unpaired electrons even under conditions where they accumulate, leading to the unique characteristics of radical ensembles with open-shell structures and their molecular properties, such as magneticity, radical trapping, catalysis, charge storage, and electrical conductivity. The molecules also display fast, reversible redox reactions, which have attracted particular attention for energy conversion and storage devices. This paper reviews the electrochemical aspects of persistent radicals and the corresponding macromolecules, radical polymers. Radical structures and their redox reactions are introduced, focusing on redox potentials, bistability, and kinetic constants for electrode reactions and electron self-exchange reactions. Unique charge transport and storage properties are also observed with the accumulated form of redox sites in radical polymers. The radical molecules have potential electrochemical applications, including in rechargeable batteries, redox flow cells, photovoltaics, diodes, and transistors, and in catalysts, which are reviewed in the last part of this paper.

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“…Robust radicals also have various other applications, such as sensors, ,, actuators, electrocatalysis, and recently desalination.…”

Section: Application Of Organic Radicals In Energy Conversion/storage...mentioning

confidence: 99%

Redox: Organic Robust Radicals and Their Polymers for Energy Conversion/Storage Devices

Hatakeyama-Sato,

Oyaizu

2023

Chem. Rev.

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“…In this regard, we report for the first time a single agent with multiple functionalities: (1) high ER and LDs specific targeting, (2) simultaneous imaging of ER and LDs with dual fluorescence, and (3) photosensitization of both ER and LDs for cancer therapy (Figure A). We and others have shown that fluorinated boron-dipyrromethene (BODIPY)-based systems are promising design choices individually for cellular imaging, photosensitization and targeting. − Further, for functional tuning and rational designing of an advanced PDT agent, we have chosen “Naphthalene Scaffold” for following attributes. (i) ER targeting : Naphthalene based various natural and synthetic drugs target ER membrane efficiently. − (ii) Simultaneous ER-LD dual imaging : Considering relatively more hydrated liquid disordered phase in ER membrane than LD, we anticipated that self-aggregation properties of naphthalene moiety , may influence the fluorescence emission of BODIPY backbone in ER and LDs.…”

Section: Introductionmentioning

confidence: 99%

A BODIPY-Naphtholimine-BF₂ Dyad for Precision Photodynamic Therapy, Targeting, and Dual Imaging of Endoplasmic Reticulum and Lipid Droplets in Cancer

Chauhan,

Koli,

Ghosh

et al. 2024

JACS Au

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“…We and others have shown that BODIPY-based systems are promising design choices individually for cellular imaging, photosensitizations and targeting. [20][21][22] For rationale designing and functional tuning, we have chosen "Naphthalene Scaffold" for following attributes. (i) ER targeting: Naphthalene based various natural and synthetic drugs target ER efficiently.…”

mentioning

confidence: 99%

A BODIPY-naphtholimine-BF₂dyad for precision photodynamic therapy, targeting and dual imaging of endoplasmic reticulum and lipid droplets in cancer

Chauhan,

Koli,

Ghosh

et al. 2024

Preprint

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Currently effective therapeutic modalities for pancreatic ductal adenocarcinoma (PDAC) is not available, leading to gloomy prognosis and ~6-months median patient survival. Recent advances showed the promise of photodynamic therapy (PDT) for PDAC patients. Next generation photosensitizers (PS) are based on organelle-targeted-PDT and provides new paradigm in the field of precision medicines to address the current challenge for treating PDAC. In this investigation, we have constructed a novel PS, named as NbB, for precise targeting of endoplasmic reticulum (ER) and lipid droplets (LD) in PDAC, as malignant PDAC cells are heavily relying on ER for hormone synthesis. Our live cell imaging and fluorescence recovery after photo-bleaching (FRAP) experiments revealed that NbB is instantly targeted to ER and LD and show simultaneous dual fluorescence colour due to polar and non-polar milieu of ER and LD. Interestingly, the same molecule generates triplet state and singlet oxygen efficiently and cause robust ER stress and apoptosis in two different PDAC cells in the presence of light. Together, we present, for the first time, a potential next generation precision medicine for ER-LD organelle specific imaging and PDT of pancreatic cancer.

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Stable, triplet ground state BODIPY-TEMPO diradical as a selective turn on fluorescence sensor for intracellular labile iron pool

Cited by 4 publications

References 41 publications

Redox: Organic Robust Radicals and Their Polymers for Energy Conversion/Storage Devices

Redox: Organic Robust Radicals and Their Polymers for Energy Conversion/Storage Devices

A BODIPY-Naphtholimine-BF₂ Dyad for Precision Photodynamic Therapy, Targeting, and Dual Imaging of Endoplasmic Reticulum and Lipid Droplets in Cancer

A BODIPY-naphtholimine-BF₂dyad for precision photodynamic therapy, targeting and dual imaging of endoplasmic reticulum and lipid droplets in cancer

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Stable, triplet ground state BODIPY-TEMPO diradical as a selective turn on fluorescence sensor for intracellular labile iron pool

Cited by 4 publications

References 41 publications

Redox: Organic Robust Radicals and Their Polymers for Energy Conversion/Storage Devices

Redox: Organic Robust Radicals and Their Polymers for Energy Conversion/Storage Devices

A BODIPY-Naphtholimine-BF2 Dyad for Precision Photodynamic Therapy, Targeting, and Dual Imaging of Endoplasmic Reticulum and Lipid Droplets in Cancer

A BODIPY-naphtholimine-BF2dyad for precision photodynamic therapy, targeting and dual imaging of endoplasmic reticulum and lipid droplets in cancer

Contact Info

Product

Resources

About

A BODIPY-Naphtholimine-BF₂ Dyad for Precision Photodynamic Therapy, Targeting, and Dual Imaging of Endoplasmic Reticulum and Lipid Droplets in Cancer

A BODIPY-naphtholimine-BF₂dyad for precision photodynamic therapy, targeting and dual imaging of endoplasmic reticulum and lipid droplets in cancer