Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute

Baker, A. G.; Cui, Hong; Ballios, Brian G.; Ing, Sonja; Yan, Peng; Wolfer, J; Wright, Tom; Dang, Mickael; Gan, Nicola Y.; Cooke, Michael J.; Ortín-Martínez, Arturo; Wallace, Valerie A.; Kooy, Derek van der; Devenyi, Robert G.; Shoichet, Molly S.

doi:10.1016/j.biomaterials.2021.120750

Cited by 40 publications

(34 citation statements)

References 61 publications

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“…Injectable [51,[53][54][55]59,61]; tissue engineering [59]: bone [54], cartilage [53,55]; Bioprinting [55]; pH responsive property [51]; drug release [51]; vitreous substitute [61] Dihydrazide + Aldehyde + [56,59] Oxyamine + aldehyde/Ketone [61] Table 1. Cont.…”

Section: Schiff Base Formationmentioning

confidence: 99%

“…The hydrogels showed tunable gelation times ranging from 15 min to 0,4 min by increasing aldehyde concentration, which enabled their injectability. The hydrogels showed cytocompatibility with retinal cells and a controlled swelling being able to maintain the ocular pressure in vivo (rabbit assays) over 56 days maintaining a healthy functional retina [ 61 ].…”

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

“…These systems display applications in tissue engineering because of their ability to encapsulate various cell lines, such as chondrocytes and ATDC5 cells that promote cartilage regeneration [ 53 , 55 ]. Schiff-base grounded hyaluronic acid hydrogels also induce angiogenesis processes [ 59 ], enhance the osteogenic functionalities and mechanical properties of bone tissue [ 54 ], and may be used as bioinks for fabricating cell-laden structures using a 3D printer [ 55 ] and as vitreous substitutes for ophthalmological applications [ 61 ]. These types of hydrogels have been employed as drug delivery systems for pH-mediated release of the anticancer drug Doxorubicin (Dox) [ 51 ].…”

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

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Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

et al. 2021

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Hyaluronic acid (HA) hydrogels display a wide variety of biomedical applications ranging from tissue engineering to drug vehiculization and controlled release. To date, most of the commercially available hyaluronic acid hydrogel formulations are produced under conditions that are not compatible with physiological ones. This review compiles the currently used approaches for the development of hyaluronic acid hydrogels under physiological/mild conditions. These methods include dynamic covalent processes such as boronic ester and Schiff-base formation and click chemistry mediated reactions such as thiol chemistry processes, azide-alkyne, or Diels Alder cycloaddition. Thermoreversible gelation of HA hydrogels at physiological temperature is also discussed. Finally, the most outstanding biomedical applications are indicated for each of the HA hydrogel generation approaches.

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Section: Schiff Base Formationmentioning

confidence: 99%

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

Section: Overview Of Ha Crosslinking Reactions Carried Out At Physiological Conditionsmentioning

confidence: 99%

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Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

et al. 2021

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“…There was no loss of retinal function or abnormal IOP at 1 and 6 months in the polyzwitterionic hydrogel‐filled rabbit eyes. In another click‐crosslinked gel, Baker and coworkers reported for the first time an oxime hydrogel for vitreous replacement 88 . Hyaluronan‐aldehyde (HAA) and hyaluronan‐ketone (HAK) were crosslinked with poly(ethylene glycol)‐tetraoxyamine (PEGOA 4 ) via oxime chemistry and formed a gel in situ after injection using a syringe coupler (Figure 2A).…”

Section: Why Use Thermogels For the Eye?mentioning

confidence: 99%

Recent developments of temperature‐responsive polymers for ophthalmic applications

Loh

2022

Journal of Polymer Science

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Blindness is one of the most feared disabilities. From cataracts and glaucoma to age-related macular degeneration and retinal vascular diseases, ocular diseases have adverse impacts on patients and pose a huge burden to the healthcare system. The World Health Organization estimates that out of 2.2 billion people with visual impairment, almost half of the cases can be preventedor has yet to be addressed. This presents an urgent clinical and societal need to be met. Temperature-sensitive hydrogels are one of the most biocompatible materials, which can be applied into the eye. By exploiting physiological temperature as a stimulus for in situ gel formation, control of the mechanical properties, rate of drug release, and biomechanical interactions can be tuned.They are very versatile and have immense potential in ocular applications by acting as vitreous substitutes in retinal surgery or topical eye drops and lenses for ocular discomfort and inflammation. In this article, we provide a review of the recent developments in temperature-responsive polymers in ophthalmic therapy in the past 5 years including retinal detachment, retinal vascular diseases, dry eyes, cataracts, age-related macular degeneration, and glaucoma.

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“…Baker et al (2021) studied the physical and chemical properties of HA-oxime hydrogels [ 98 ]. These hydrogels were composed of hyaluronan modified with aldehyde (HAA) or ketone (HKA) cross-linked to PEG-tetraoxyamine (PEGOA₄).…”

Section: Hydrogels Used As Vitreous Substitutesmentioning

confidence: 99%

Recent Advances in Hydrogels: Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular Adhesives

et al. 2021

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With the prevalence of eye diseases, such as cataracts, retinal degenerative diseases, and glaucoma, different treatments including lens replacement, vitrectomy, and stem cell transplantation have been developed; however, they are not without their respective shortcomings. For example, current methods to seal corneal incisions induced by cataract surgery, such as suturing and stromal hydration, are less than ideal due to the potential for surgically induced astigmatism or wound leakage. Vitrectomy performed on patients with diabetic retinopathy requires an artificial vitreous substitute, with current offerings having many shortcomings such as retinal toxicity. The use of stem cells has also been investigated in retinal degenerative diseases; however, an optimal delivery system is required for successful transplantation. The incorporation of hydrogels into ocular therapy has been a critical focus in overcoming the limitations of current treatments. Previous reviews have extensively documented the use of hydrogels in drug delivery; thus, the goal of this review is to discuss recent advances in hydrogel technology in surgical applications, including dendrimer and gelatin-based hydrogels for ocular adhesives and a variety of different polymers for vitreous substitutes, as well as recent advances in hydrogel-based retinal pigment epithelium (RPE) and retinal progenitor cell (RPC) delivery to the retina.

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Stable oxime-crosslinked hyaluronan-based hydrogel as a biomimetic vitreous substitute

Cited by 40 publications

References 61 publications

Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

Hyaluronic Acid Hydrogels Crosslinked in Physiological Conditions: Synthesis and Biomedical Applications

Recent developments of temperature‐responsive polymers for ophthalmic applications

Recent Advances in Hydrogels: Ophthalmic Applications in Cell Delivery, Vitreous Substitutes, and Ocular Adhesives

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