Stable Monomeric Germanium(<scp>II</scp>) and Tin(<scp>II</scp>) Compounds with Terminal Hydrides

Pineda, Leslie W.; Jancik, Vojtech; Starke, Kerstin; Oswald, Rainer; Roesky, Herbert W.

doi:10.1002/ange.200504337

Cited by 71 publications

(45 citation statements)

References 49 publications

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“…Die Germylene und Stannylene mit terminalen Hydridliganden (32),47) sowie das Chlorsilylen (33) (M = Ge, Sn),48) zeigen stark pyramidalisierte Ge‐, Sn‐ bzw. Si‐Atome, deren pseudo‐tetraedrische Koordinationsumgebungen durch die freien Elektronenpaare vervollständigt werden.…”

Section: Niedervalente Verbindungenunclassified

Differentiation rather than aging of muscle stem cells abolishes their telomerase activity

O’Connor

Carlson

Conboy

2009

Biotechnology Progress

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A general feature of stem cells is the ability to routinely proliferate in order to build, maintain, and repair organ systems. Accordingly, embryonic and germline, as well as some adult stem cells, produce the telomerase enzyme at various levels of expression. Our results show that, while muscle is a largely post-mitotic tissue, the muscle stem cells (satellite cells) that maintain this biological system throughout adult life do indeed display robust telomerase activity. Conversely, primary myoblasts (the immediate progeny of satellite cells) quickly and dramatically down-regulate telomerase activity. This work thus suggests that satellite cells, and early transient myoblasts, may be more promising therapeutic candidates for regenerative medicine than traditionally utilized myoblast cultures. Muscle atrophy accompanies human aging, and satellite cells endogenous to aged muscle can be triggered to regenerate old tissue by exogenous molecular cues. Therefore, we also examined whether these aged muscle stem cells would produce tissue that is “young” with respect to telomere maintenance. Interestingly, this work shows that the telomerase activity in muscle stem cells is largely retained into old age wintin inbred “long” telomere mice and in wild-derived short telomere mouse strains, and that age-specific telomere shortening is undetectable in the old differentiated muscle fibers of either strain. Summarily, this work establishes that young and old muscle stem cells, but not necessarily their progeny, myoblasts, are likely to produce tissue with normal telomere maintenance when used in molecular and regenerative medicine approaches for tissue repair.

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Section: Niedervalente Verbindungenunclassified

Differentiation rather than aging of muscle stem cells abolishes their telomerase activity

O’Connor

Carlson

Conboy

2009

Biotechnology Progress

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“…The terphenyl derivatives exist in the solid state as dimeric structures, [2] whereas the bdiketiminate species incorporates a terminal tin(II) hydride with very weak intermolecular interactions. [3] Until recently, reactions of organotin hydrides were based on tin(IV) precursors. Di-and triorganotin hydrides, of composition R 2 SnH 2 and R 3 SnH, with a formal oxidation state of Sn IV undergo a rich variety of chemical transformations.…”

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confidence: 99%

Reactions of Tin(II) Hydride Species with Unsaturated Molecules

et al. 2009

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If anything can, tin can: The tin(II) hydride species [LSnH] (L=HC{CMeN(2,6‐iPr2C6H3)}2) reacts with various compounds containing unsaturated CO, CC, or CN bonds, which results in simultaneous transfer of hydrogen and {LSn} to the organic substrates and elegantly generates new tin(II) compounds. These unique stannylene compounds incorporate a lone pair of electrons that is suitable for complexation with transition‐metal species.

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“…A different approach to utilise the chloride substituent for the creation of a new NHGe family is reported by the Roesky group [28][29][30][31][32]. In a reaction of the NHGeCl with an Arduengo-Wanzlick carbene (1,3-dimesityl-imidazol-2-ylidene) in the presence of water, the carbene acted as auxiliary base resulting in the substitution of the chloride substituent by a OH-group [32] (see Fig.…”

Section: Six-membered Nhgementioning

confidence: 99%

“…Both functional groups were successfully exploited. This was done in the reaction with [Cp 2 ZrMe 2 ] [29]. The germanium atom can act as a classical -donor ligand utilising its electron lone pair.…”

Section: Six-membered Nhgementioning

confidence: 99%