Stable Modification of PDMS Surface Properties by Plasma Polymerization:  Application to the Formation of Double Emulsions in Microfluidic Systems

Barbier, Valessa; Tatoulian, Michaël; Li, Hong; Arefi‐Khonsari, Farzaneh; Ajdari, and Armand; Tabeling, Patrick

doi:10.1021/la053289c

Cited by 153 publications

(139 citation statements)

References 21 publications

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“…A timing difference can occur when droplet production in coupled droplet generators is not synchronous, as Barbier et al have characterized experimentally for a wide range of conditions. 47 Although we do not take steps to avoid timing differences, such non-synchronous behavior can be a limitation to the practical use of devices such as these.…”

Section: Observations Of Droplet Collisions At T-junctionsmentioning

confidence: 99%

Coalescence and splitting of confined droplets at microfluidic junctions

et al. 2009

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The ability to merge two droplets is an important component of droplet-based lab-on-a-chip devices, yet flow-induced coalescence is difficult to achieve due to long film drainage times compared with relatively short residence times. We examine droplet collisions at a simple microfluidic T-junction and characterize the response for a wide range of droplet sizes and speeds. We find that three primary responses occur, where coalescence occurs easily at low collision speeds, smaller droplets traveling faster slip past one another without coalescing, and larger and faster droplets can break one another into multiple segments. The critical capillary number for coalescence agrees well with previously reported scaling for isolated droplet pairs when local curvature and speed are taken into account. The critical capillary number for splitting of droplets agrees well with a previously reported stability condition for individual droplets stretching in an extensional flow. Quantifying the necessary conditions for coalescence and non-coalescence behavior should enable the informed design of lab on chip devices based on discrete liquid segments.

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Section: Observations Of Droplet Collisions At T-junctionsmentioning

confidence: 99%

Coalescence and splitting of confined droplets at microfluidic junctions

et al. 2009

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“…Barbier et al [92] deposited 200 µm lines of ppPAcAc onto PDMS, using a masking technique similar to what is described in earlier paragraphs. These patterned surfaces were then successfully implemented into a microfluidic device to transport direct and double emulsions, which was first tried for PDMS samples and is shown in Figure 7.…”

Section: Cooh-rich Geometric Domainsmentioning

confidence: 99%

“…Further analysis revealed that the adsorption of Ca 2+ played a critical role in the selection and that only cell-lines, such as the RINm5f tumour cells, which express Ca 2+ dependant membrane proteins are susceptible to the applied pattern. Source: Barbier et al [92] Finally Filova et al [94] did an extensive study on the cell response of four different cell types (rat smooth muscle cells, human and porcine skeletal muscle cells and bovine endothelial cells) to patterns generated via the plasma polymerisation of ppAcAc and 1,7-octadiene. A TEM grid was used to generate tracks of approximately 100 µm.…”

Section: Cooh-rich Geometric Domainsmentioning

confidence: 99%

Non-thermal plasma assisted lithography for biomedical applications: an overview

Cools

Morent

2016

IJNT

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Plasma assisted surface patterning is becoming a well-established technique that introduces both alternating surface texture and chemistry on substrates for biomedical applications. This review consists of an overview on the developments in this field over the last 15 years. Special attention is given to the different kinds of chemistry that can be introduced and their effect on the surface-cell interaction, as well as their feasibility for possible applications in the field of regenerative medicine.

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“…Kovach and his co-workers [29] achieved long term hydrophilicity and hemocompatibility of PDMS microchannels using a plasma-assisted polyethylene glycol (PEG) grafting. Barbier et al [30] deposited plasma polymerized acrylic acid coatings onto unbonded PDMS and implemented for the first time a system to form double emulsions in microchips. This method, though, was performed in vacuum with limitations for implementing on a laboratory scale due its expense.…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic Surface Modification of PDMS Microchannel for O/W and W/O/W Emulsions

Bashir

Solvas

et al. 2015

Micromachines

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A surface modification method for bonded polydimethylsiloxane (PDMS) microchannels is presented herein. Polymerization of acrylic acid was performed on the surface of a microchannel using an inline atmospheric pressure dielectric barrier microplasma technique. The surface treatment changes the wettability of the microchannel from hydrophobic to hydrophilic. This is a challenging task due to the fast hydrophobic recovery of the PDMS surface after modification. This modification allows the formation of highly monodisperse oil-in-water (O/W) droplets. The generation of water-in-oil-in-water (W/O/W) double emulsions was successfully achieved by connecting in series a hydrophobic microchip with a modified hydrophilic microchip. An original channel blocking technique to pattern the surface wettability of a specific section of a microchip using a viscous liquid comprising a mixture of honey and glycerol, is also presented for generating W/O/W emulsions on a single chip.

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Stable Modification of PDMS Surface Properties by Plasma Polymerization: Application to the Formation of Double Emulsions in Microfluidic Systems

Cited by 153 publications

References 21 publications

Coalescence and splitting of confined droplets at microfluidic junctions

Coalescence and splitting of confined droplets at microfluidic junctions

Non-thermal plasma assisted lithography for biomedical applications: an overview

Hydrophilic Surface Modification of PDMS Microchannel for O/W and W/O/W Emulsions

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