Stable lanthanide metal–organic frameworks as ratiometric fluorescent probes for the efficient detection of riboflavin

Sun, Xue-Chun; Cong, Zhenzhong; Wu, Shuangyan; Zhang, Ying; Zhu, Mingchang; Bai, Xiao‐Jue

doi:10.1039/d2tc02947b

Cited by 14 publications

(9 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The linear ranges and the limit of detection are 0.005–0.1 and 0.002 nM, respectively. To the best of our knowledge, the LOD value for RF is far superior to those values given from other methods. − ,− The selectivity of the photoluminescence sensor is challenged by some potentially interfering substances that possibly exist in the rat brain, such as metal ions, anions, amino acids, glucose, nicotinamide, uric acid, ascorbic acid, folic acid, dopamine, glutathione (GSH), bovine serum albumin (BSA), or hydrogen peroxide (H 2 O 2 ). The photoluminescence spectra of Ade-AuNCs without and with RF (0.05 nM) or each interferent (0.05 nM) are displayed in Figure A, and the selectivity plot is shown in Figure B–E.…”

Section: Resultsmentioning

confidence: 99%

Water-Soluble Photoluminescent Adenosine-Functionalized Gold Nanoclusters as Highly Sensitive and Selective Receptors for Riboflavin Detection in Rat Brain

Zeng

Cao

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

Simple, selective, and sensitive detection of cerebral riboflavin is of great significance due to the vital roles of riboflavin in physiological and pathological processes. In the work, watersoluble photoluminescent adenosine-functionalized gold nanoclusters (Ade-AuNCs) are exploited as highly sensitive and selective receptors for cerebral riboflavin detection. The Ade-AuNCs are prepared under aqueous conditions by the one-step "synthesis-functionalization integration" strategy, using chloroauric acid as gold precursors and adenosine as outer-shell ligands. During the Ade-AuNCs synthesis process, adenosine and ascorbic acid are demonstrated to respectively serve as a stabilizer and a reductant, and citrate buffer plays multiple roles including a pH regulator, reductant, and complexing agent. The added riboflavin causes photoluminescence quenching of Ade-AuNCs, and the quenching photoluminescence is applied for well quantifying riboflavin in the range of 0.005−0.1 nM with a detection limit of 0.002 nM. The detailed analytical characterizations reveal that the photoluminescence quenching results from the static photoinduced electron transfer process from the surface functional Ade-AuNCs to riboflavin and the strong affinity between Ade-AuNCs and riboflavin. Moreover, the Ade-AuNC-based sensor exhibits a high selectivity for riboflavin over metal ions, anions, amino acids, and biological substances that possibly exist in the rat brain. Finally, by coupling the microdialysis technique, the proposed sensor is successfully applied to detect riboflavin in living rat brain microdialysates with a basal value of 13.1 ± 2.5 nM (n = 3), and the results are comparable well with those from a reference highperformance liquid chromatography method.

show abstract

Section: Resultsmentioning

confidence: 99%

Water-Soluble Photoluminescent Adenosine-Functionalized Gold Nanoclusters as Highly Sensitive and Selective Receptors for Riboflavin Detection in Rat Brain

Zeng

Cao

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…Metal–organic frameworks (MOFs), constructed by self-assemble of organic ligands and metal ions or metal nodes, − have drawn increased attention due to their potential applications in gas storage, molecular separations, and chemical sensing, as well as catalysis . Especially, MOFs have attracted great attention in the field of ratiometric fluorescence sensing. − Considering that the luminescence of MOFs could originate from ligands, metal ions, the charge interaction between ligands and metal ions, and guest molecules, the multiple emission centers of MOFs can be mainly obtained by introducing single or multiple lanthanide ions, , luminescent guest molecules, , carbon dots, Ru(bpy) 3 2+ , and different organic linkers, along with lanthanide-based MOFs (Ln-MOFs) with single organic ligand and lanthanide ions. , Among them, most of the strategies generally require a complex post-synthetic modification process; thus, Ln-MOFs that are synthesized directly can be constructed as an ideal ratiometric fluorescence platform. The luminescence of Ln-MOFs mainly depends on the energy transfer (antenna effect) from the linkers to Ln 3+ ions .…”

Section: Introductionmentioning

confidence: 99%

Novel Lanthanide-Based Metal–Organic Framework Isomer as a Double Ratiometric Fluorescent Probe for Vanillymandelic Acid

Fan

Liu²,

Cheng

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The concentration of vanillymandelic acid (VMA) in urine is closely related with pheochromocytoma diagnosis. Thus, it is essential to develop more accurate and convenient fluorescence sensing strategies toward VMA. Until now, the design of double ratiometric detection methods for VMA was still in the unexplored stage. In this work, novel Ln3+-based metal–organic frameworks (QBA-Eu and QBA-Gd0.875Eu0.125) possessing dual emission peaks was fabricated successfully, which served as isomers of YNU-1 and exhibited more excellent water stability in fluorescence and structure than the ones of YNU-1. The formation of the complex between QBA ligands and VMA molecules via hydrogen bonds within QBA-Eu frameworks produced a new emission band centered at 450 nm and resulted in the decline of monomer emission intensity for QBA at 390 nm. Owing to the reduced energy gap [ΔE (S1 – T1)], the antenna effect was hampered and luminescence of Eu3+ ions also decreased. The developed double ratiometric (I 615nm/I 475nm, I 390nm/I 475nm) fluorescence sensors based on QBA-Eu and QBA-Gd0.875Eu0.125 possessed the advantages of fast response (4 min), low detection limits (0.58 and 0.51; 0.22 and 0.31 μM), and wide linear ranges (2–100 and 2–80 μM), which met the requirements of pheochromocytoma diagnosis. We also applied them to determine VMA in an artificial urine sample and diluted human urine sample and obtained satisfactory results. They will become prospective fluorescence sensing platforms for VMA.

show abstract

“…Therefore, the strategic adjustment of the length of the pyridyl donor ligands and changing the metal center ions allowed us to control the selfassembly behavior of the systems. [34][35][36][37][38][39] Transdermal drug delivery systems (TDDSs) are an innovative approach for delivering drugs into the blood at a controlled rate via the skin. TDDSs avoid the rst-pass effect and improve patient compliance because they are applied topically.…”

Section: Introductionmentioning

confidence: 99%

Coordination-directed self-assembly of nano-cages: metal ion-change, ligand-extending, shape-control and transdermal drug delivery

2023

Self Cite

View full text Add to dashboard Cite

show abstract

Stable lanthanide metal–organic frameworks as ratiometric fluorescent probes for the efficient detection of riboflavin

Abstract: The rational design and exploration of fluorescent probes for the efficient detection of Riboflavin (RF), is of great significance. Herein, a series of isostructural Ln-MOFs (Ln-BPTA) with different metal nodes...

Cited by 14 publications

References 49 publications

Water-Soluble Photoluminescent Adenosine-Functionalized Gold Nanoclusters as Highly Sensitive and Selective Receptors for Riboflavin Detection in Rat Brain

Water-Soluble Photoluminescent Adenosine-Functionalized Gold Nanoclusters as Highly Sensitive and Selective Receptors for Riboflavin Detection in Rat Brain

Novel Lanthanide-Based Metal–Organic Framework Isomer as a Double Ratiometric Fluorescent Probe for Vanillymandelic Acid

Coordination-directed self-assembly of nano-cages: metal ion-change, ligand-extending, shape-control and transdermal drug delivery

Contact Info

Product

Resources

About