Stable Isotopes (O, H, and S) in the Muteh Gold Deposit, Golpaygan Area, Iran

Abdollahi, Mahdieh; Karimpour, Mohammad Hassan; Kheradmand, A; Zarasvandi, Alireza

doi:10.1007/s11053-009-9091-3

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…Teucrium species have been used for more than 2000 years as medicinal herb for a great range of actions: antispasmodic, hypolipidemic, anti-inflammatory, and hypoglycemic [9][10][11][12][13][14].…”

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confidence: 99%

Fatty acid, tocopherol, and sterol content of three Teucrium species from Tunisia

Hachicha¹,

Barrek²,

Skanji³

et al. 2009

Chem Nat Compd

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In the present study analyses concerning the composition of vitamin E, sterols, triglycerides, and fatty acids of three Teucrium species (Teucrium alopecurus, T. nabli, and T. polium) seed oil were performed. Linoleic, linolenic, and palmitic were the major fatty acids. The oil was characterized by a high amount of phytosterol, wherein clerosterol, sitosterol, and stigmasterol are the main constituents. The amount of tocopherol is nearly 550 mg/kg of oil, with α-tocopherol as the major isomer. Information concerning the composition of Teucrium seed oil is very important for evaluating the therapeutic effect of this oil.Natural seed oils are mixtures of triacylglycerides (95-98%) and a wide range of compounds like wax esters, sterols, tocopherols, phospholipids, phenolics derivatives, etc. (2-5%) [1].Phytosterol and tocopherol are among the most interesting lipophilic constituents, and they have multiple beneficial effects. Tocopherol plays an important role in the prevention of some chronic diseases and certain kinds of cancer [2], while phytosterol and specifically beta-sitosterol are known to lower serum cholesterol concentration and atherosclerotic risk [3,4].Teucrium genus (Labiatae) is found through the world but mainly in the Mediterranean basin with 220 taxa [5], 19 of which grow in Tunisia [6][7][8]. Teucrium species have been used for more than 2000 years as medicinal herb for a great range of actions: antispasmodic, hypolipidemic, anti-inflammatory, and hypoglycemic [9][10][11][12][13][14].Phytochemical investigations have shown that the aerial part of Teucrium species contains various compounds such as flavonoids, diterpenes, iridoids, etc. Teucrium alopecurus and Teucrium nabli are two endemic species limited to south Tunisia [6,8]. The seeds of this plant and of Teucrium polium have not been explored. The objective of our work was to characterize the chemical composition of seed oil (fatty acids, triglycerides, vitamin E, and sterols) from three Teucrium species (Teucrium alopecurus, Teucrium nabli, and Teucrium polium), which could have very interesting cosmetic and/or pharmaceutical uses.Teucrium seeds averaged 1% yield, with T. nabli exhibiting the highest yields (1.2%). According to the results shown in the Table 1, eleven fatty acids were identified; hydrocarbons were also detected but not included in Table 1.The fatty acid content of the seed oil of the three Teucrium species showed big quantitative differences (Table1). The most abundant fatty acids were linoleic, linolenic, and palmitic acids, which together comprised 89.2%, 74.2%, and 62.6%, respectively, in T. nabli, T. alopecurus, and T. polium total fatty acids. The analysis of FAME of different species showed that lauric acid was found in relatively high amounts (9%) in T. polium; this acid is less important in T. alopecurus and T. nabli (2% and 1.6%). T. polium and T. alopecurus seed oil presented the highest amounts of C28:0, 9% and 5.9%, respectively, whereas T. nabli had the lowest value, 3%. The ratio of unsaturated to saturated fat...

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confidence: 99%

Fatty acid, tocopherol, and sterol content of three Teucrium species from Tunisia

Hachicha¹,

Barrek²,

Skanji³

et al. 2009

Chem Nat Compd

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“…Flavonoids, an important class of naturally occurring compounds, have demonstrated CNS activities such as affinity for GABAA receptors and anticonvulsant effects (Miliauskas et al, 2004, Huen et al, 2003. Some researchers have reported anticonvulsant activity of apigenin as glucoside flavonoid of T. polium (Abdollahi et al, 2003, Kawashty et al, 1999. Triterpenes are reported to possess anticonvulsant activity in some experimental seizure models like PTZ and MES.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant activity of the aqueous extract of <i>Allium cepa</i> L. (Amaryllidaceae) in rats and mice

Anaka¹,

RI²,

Ikpefan³

et al. 2014

J. Pharm Bio.

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The aqueous extract of Allium cepa (ACE) has been reported to be effective in the treatment of convulsion. We therefore investigated its effect on seizures induced by maximal electroshock stimulation (MES) and pentylenetetrazole (PTZ) in rats and mice. The preliminary phytochemical constituents were also elucidated. The extract contained tannins, flavonoids, cardiac glycosides, reducing sugars, saponins and alkaloids. Anthraquinones, steroids and terpenes were absent. In the electrically-induced seizure, ACE significantly (p< 0.01) prolonged the onset of tonic convulsion at all doses. It also reduced the duration of the tonic convulsion at all doses but it is only significant at 50mg/kg (p< 0.02), 200mg/kg (p< 0.03) and 400mg/kg (p< 0.004). It was reduced from 3.295 ± 0.448s (control) to 1.172 ± 0.837s (50mg/kg); 1.62 ± 0.670s (200mg/kg) and 0.832 ± 0.376s (400mg/kg). In the PTZinduced seizure ACE prolonged the onset of tonic convulsion at 50mg/kg and 200mg/kg dose but it was insignificant. It was increased from 3.469 ± 1.335 min (control) to 3. 999 ± 1.658 min (50mg/kg) and 4.261 ± 0.740 min (200mg/kg). It also delayed the time it took for the mice to die at 50mg/kg and 200mg/kg, although not significantly. It is concluded that Allium cepa extract has an anticonvulsant effect especially in MES-induced seizure and could serve as a good alternative for the treatment of convulsion. This observation explains, at least in part, the basis for its use by herbalists for the treatment of convulsion.

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“…[13][14][15] Among them, Teucrium polium is a medicinal plant belonging to the Labiatae family. This plant has been reported to have hypolipidemic, 16 hypoglycaemic, 17 anti-nociceptive 18 and anti-inflammatory 19 effects, but few adverse effects of T. polium have been described indicating the relatively safe nature of this medicinal herb. 20 From the ethyl acetate root extract we isolated 13 abeo-abietane diterpenes, including six new analogues.…”

Section: Introductionmentioning

confidence: 99%

abeo-Abietanes from Teucrium polium roots as protective factors against oxidative stress

Fiorentino

D’Abrosca

Pacifico

et al. 2010

Bioorganic & Medicinal Chemistry

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Stable Isotopes (O, H, and S) in the Muteh Gold Deposit, Golpaygan Area, Iran

Cited by 13 publications

References 19 publications

Fatty acid, tocopherol, and sterol content of three Teucrium species from Tunisia

Fatty acid, tocopherol, and sterol content of three Teucrium species from Tunisia

Anticonvulsant activity of the aqueous extract of <i>Allium cepa</i> L. (Amaryllidaceae) in rats and mice

abeo-Abietanes from Teucrium polium roots as protective factors against oxidative stress

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