Stable Ischemic Heart Disease

Genetics: Implications for Prevention and Management of Coronary Artery Disease

“…This increased incidence is due to several factors, including increasing lifespans, changes in lifestyle, adoption of Western diets, and many others (1). Despite the global increased prevalence of CAD, its incidence in the developed world decreased substantially after the implementation of effective primary and secondary prevention strategies in the latter part of the 20 th century (2,3). These strategies include the promotion of a healthy lifestyle anchored on optimal nutrition, smoking cessation, and increased physical activity, as well as the development of effective pharmacological therapies, such as platelet and 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors.…”

“…These strategies include the promotion of a healthy lifestyle anchored on optimal nutrition, smoking cessation, and increased physical activity, as well as the development of effective pharmacological therapies, such as platelet and 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Collectively, these strategies are able to reduce the incidence of CAD by almost 50% in high-risk populations (2,3).…”

Paradigm change for stable coronary disease in chronic coronary syndrome: Novelties in the guidelines of the European Society of Cardiologists from 2019

“…[133,134]. Komparacija između PCI i OMT (Braunwald s Heart disease, 2015-Morow D, Boden WE) [135]. n-) u smislu ranijih tehnika balon angioplastika vs medikalna terapija, pripada istoriji, sada u eri novih tehnika PCI i nove optimalne terapije lekovima.…”

“…RAP kao oblik hroničnog koronarnog sindroma (HKS) se definiše kao hronično stanje izazvano klinički ustanovljenom reverzibilnom ishemijom u prisustvu KB, koje se ne može adekvatno kontrolisati kombinacijom medikalne terapije, angioplastike sa stentingom (PCI) ili hirurškom koronarnom revaskularizacijom (CABG) [1,120] [135].…”

Echocardiographic evaluation of a single bolus of erythropoietin effects on reducing ischemia-reperfusion injuries during coronary artery bypass graft surgery. A randomized, double blinded placebo control study

“…11 Although the rapid reperfusion by CABG significantly reduces mortality and morbidity, 12 this reperfusion paradoxically may contribute to myocardial stunning injuries and/or death after CABG. 13 , 14 Therefore, new treatment modalities should focus on decreasing damage after reperfusion.…”