Stable Colloidal Copper Nanoparticles Functionalized with Siloxane Groups and Their Microbicidal Activity

Porta, Estanislao; Cogliati, Sebastián; Marcos, Francisco; Roldán, María Virginia; Mamana, Nadia; Grau, Roberto; Pellegri, N.

doi:10.1007/s10904-018-01071-2

Cited by 10 publications

(4 citation statements)

References 93 publications

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“…Ag NPs can provide bactericidal or bacteriostatic protection . Three main mechanisms of the bactericidal action of Ag NPs have been reported: (i) NPs interaction with the cell membrane and its damage by generation of reactive oxygen species, (ii) DNA damage by penetration into the bacterial cell, and (iii) release of Ag ions and their accumulation in the cell leading to cell division and disruption of the cell membrane integrity. − Cu NP toxicity is usually attributed to the ability of released Cu ions to initiate oxidative damage and depress cell division. − Metal oxide NP toxicity can be caused by oxidative stress, release of toxic ions, cellular uptake, damage of cell wall, genotoxicity, physical restrain, co-ordination effects, non-homeostasis effects, and others. , …”

Section: Introductionmentioning

confidence: 99%

Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Gudz

Antipina

Permyakova

et al. 2021

ACS Appl. Mater. Interfaces

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Utilization of antibacterial components-conjugated nanoparticles (NPs) is emerging as an attractive strategy for combating various pathogens. Herein, we demonstrate that Ag/BN NPs and antibiotic-loaded BN and Ag/BN nanoconjugates are promising carriers to fight bacterial and fungal infections. Extensive biological tests included two types of Gram-positive methicillin-resistant Staphylococcus aureus strains (B8469 and MW2), two types of Gram-negative Pseudomonas aeruginosa strains (ATCC27853 and B1307/17), and 47 types of Escherichia coli strains (including 41 multidrug-resistant ones), as well as five types of fungal cultures: Candida albicans (candidiasis-thrush) ATCC90028 and ATCC24433, Candida parapsilosis ATCC90018, Candida auris CBS109113, and Neurospora crassa wt. We have demonstrated that, even within a single genus Escherichia, there are many hospital E. coli strains with multi-drug resistance to different antibiotics. Gentamicin-loaded BN NPs have high bactericidal activity against S. aureu s, P. aeruginosa, and 38 types of the E. coli strains. For the rest of the tested E. coli strains, the Ag nanoparticle-containing nanohybrids have shown superior bactericidal efficiency. The Ag/BN nanohybrids and amphotericin B-loaded BN and Ag/BN NPs also reveal high fungicidal activity against C. albicans, C. auris, C. parapsilosis, and N. crassa cells. In addition, based on the density functional theory calculations, the nature of antibiotic-nanoparticle interaction, the sorption capacity of the BN and Ag/BN nanohybrids for gentamicin and amphotericin B, and the most energetically favorable positions of the drug molecules relative to the carrier surface, which lead to lowest binding energies, have been determined. The obtained results clearly show high therapeutic potential of the antibiotic-loaded Ag/BN nanocarriers providing a broad bactericidal and fungicidal protection against all of the studied pathogens.

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Section: Introductionmentioning

confidence: 99%

Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Gudz

Antipina

Permyakova

et al. 2021

ACS Appl. Mater. Interfaces

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“…The issues addressed above can be taken care of by using copper based materials as they are characterized by not only a natural appropriation technique to be expelled out of the body but also they are highly cost-effective and abundant in nature . Therefore, copper and copper oxide related nanostructures have emerged as excellent materials for antibacterial applications. − Many works have been established on the fabrication of copper oxide nanostructures over copper foil as a superhydrophobic surface such as CuO nanoneedles via photolithography and argon ion beam etching, CuO/Cu 2 O nanowires via photolithography, Cu 2 O/CuO nanoflowers via direct crystallization approach, Cu thin films via solution immersion method, CuO nanosheets via oxidation dehydration approach, bamboo leaf shaped Cu nanostructures via template and etching method, Cu(OH) 2 /CuO microflowers via electrodeposition, and CuO nanoflowers via wet chemical etching . The aforementioned outcomes of the reported scientific works gave us invaluable insight for the fabrication of ideal superhydrophobic and antibacterial materials.…”

Section: Introductionmentioning

confidence: 99%

Electrodeposited Cu₂O Nanopetal Architecture as a Superhydrophobic and Antibacterial Surface

et al. 2019

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Bacterial infections being sporadic and uncontrollable demands an urgent paradigm shift in the development of novel antibacterial agents. This work involves the fabrication of Cu 2 O nanopetals over copper foil that show superlative antibacterial and superhydrophobic properties. A superhydrophobic surface has been fabricated using the electrochemical deposition (ECD) method. Here, it is aimed to establish the superior antibacterial activity as an outcome of the inherent superhydrophobic property of the as-fabricated nanostructures. The present study finds that the elevated value of the water contact angle (154 ± 0.6°) does not allow proper bacterial adhesion, and it is immune from the possibility of biofouling. Specifically, two kinds of bacterial strains have been tested and the time response of the antibacterial activity has been studied over a period of 12 h, taking DH5α Escherichia coli as a Gram-negative model and Bacillus subtilis 168 as a Gram-positive model. Higher antibacterial effects were observed for the Gram-negative model (E. coli) owing to its simplistic cell wall structure which facilitates the easy diffusion of Cu + ions into the bacterial membrane. The simplicity of the developed method of fabrication along with the superlative superhydrophobic nature and excellent antibacterial property of the material, owing to its synergistic biophysical and biochemical modes of biocidal action, establishes its viability in many applications.

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“…Monodispersed and smaller sized CuO nanoparticles showed increased antibacterial activity against both Gram-negative and Gram-positive bacterial strains. It has been demonstrated that spherical Cu nanoparticles exhibited strong bactericidal activity against Gram negative as well as Gram positive bacteria [208]. Further studies showed that irradiation of TiO 2 nanospheres with UV-A rays for 60 min increased its antibacterial activity towards methicillin-resistant Staphylococcus aureus strains than the non-irradiated commercial TiO 2 nanoparticles [209].…”

Section: Antimicrobial Applications Of Nanoparticlesmentioning

confidence: 99%

Synthesis and Characterization of Nanoparticles for Antimicrobial Applications-A Review

Kumar Rasal,

Ahmed Shaik,

Iffath Badsha

et al. 2023

Applied Microbiology: Theory ＆ Technology

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Nanotechnology is an interdisciplinary science developed since the 1970s and has found tremendous commercial applications owing to their unique properties. Nanoscale materials are of the order of 1-100 nm and offer extremely advantageous optical, electronic and structural properties that are characteristic due to size-controlled features than their bulk materials. Biological methods are alternative sources of nanoparticle synthesis compared to physical and chemical techniques. Microorganisms can be used for production of different kinds of nanoparticles which are highly suitable for many industrial applications. This review provides an overview of nanotechnology, with a brief discussion of the development of nanotechnology since the ancient world and highlights the biogenic approaches of mono- and bi-metallic nanoparticle biosynthesis by different microorganisms. The mechanisms of intracellular and extracellular biosynthesis of metal nanoparticles by microorganisms is illustrated. The classical microscopic and spectroscopic techniques used for investigating the nanoparticle characteristics are also described in detail with hints for practical analysis. Meanwhile, the applications of metal nanoparticles as antimicrobial agents are summarized. In conclusion, this review includes a final outlook in the field of Microbial Nanotechnology.

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Stable Colloidal Copper Nanoparticles Functionalized with Siloxane Groups and Their Microbicidal Activity

Cited by 10 publications

References 93 publications

Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Electrodeposited Cu₂O Nanopetal Architecture as a Superhydrophobic and Antibacterial Surface

Synthesis and Characterization of Nanoparticles for Antimicrobial Applications-A Review

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Stable Colloidal Copper Nanoparticles Functionalized with Siloxane Groups and Their Microbicidal Activity

Cited by 10 publications

References 93 publications

Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Electrodeposited Cu2O Nanopetal Architecture as a Superhydrophobic and Antibacterial Surface

Synthesis and Characterization of Nanoparticles for Antimicrobial Applications-A Review

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Electrodeposited Cu₂O Nanopetal Architecture as a Superhydrophobic and Antibacterial Surface