Stable Chromosomal Inversion Polymorphisms and Insecticide Resistance in the Malaria Vector Mosquito<i>Anopheles gambiae</i>(Diptera: Culicidae)

Brooke, Basil D.; Hunt, Richard H.; Chandre, Fabrice; Coriat, Pierre; Coetzee, Maureen

doi:10.1603/0022-2585-39.4.568

Cited by 45 publications

(38 citation statements)

References 76 publications

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“…Changes in inversion frequencies were often interpreted in terms of inversion heterozygote advantage, particularly as an excess of heterokaryotypes was found in several population samples. This pattern has also been observed in population samples of Anopheles gambiae mosquitoes (Brooke et al 2002) and Coelopa frigida flies (Butlin & Day 1989). …”

Section: Frequency Changes In Populationssupporting

confidence: 66%

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Revisiting the Impact of Inversions in Evolution: From Population Genetic Markers to Drivers of Adaptive Shifts and Speciation?

Hoffmann

Rieseberg

2008

Annu. Rev. Ecol. Evol. Syst.

578

713

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There is a growing appreciation that chromosome inversions affect rates of adaptation, speciation, and the evolution of sex chromosomes. Comparative genomic studies have identified many new paracentric inversion polymorphisms. Population models suggest that inversions can spread by reducing recombination between alleles that independently increase fitness, without epistasis or coadaptation. Areas of linkage disequilibrium extend across large inversions but may be interspersed by areas with little disequilibrium. Genes located within inversions are associated with a variety of traits including those involved in climatic adaptation. Inversion polymorphisms may contribute to speciation by generating underdominance owing to inviable gametes, but an alternative view gaining support is that inversions facilitate speciation by reducing recombination, protecting genomic regions from introgression. Likewise, inversions may facilitate the evolution of sex chromosomes by reducing recombination between sex determining alleles and alleles with sex-specific effects. However, few genes within inversions responsible for fitness effects or speciation have been identified.

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Section: Frequency Changes In Populationssupporting

confidence: 66%

“…The Anopheles gambiae complex has two widespread paracentric inversions (2La and 2Rb) associated with dieldrin resistance (2La) and DDT resistance (2Rb) (Brooke et al 2002). However, dieldrin resistance is not associated with 2La in at least one African population (Brooke et al 2006).…”

Section: Candidate Traitsmentioning

confidence: 99%

Revisiting the Impact of Inversions in Evolution: From Population Genetic Markers to Drivers of Adaptive Shifts and Speciation?

Hoffmann

Rieseberg

2008

Annu. Rev. Ecol. Evol. Syst.

578

713

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“…In the only examination of 2La genotypes under indoor selection pressure to our knowledge, the 2L+ a /2L+ a frequency increased from 0% detectable in 1994 before ITN rollout in western Kenya to 66% by 2011 after rollout (Matoke-Muhia et al, 2016). The 2La inversion is not genetically associated with resistance to the pyrethroid insecticides used on ITNs (Brooke et al, 2002), so the underlying mechanism is more likely to be behavioral avoidance rather than chemical selection. At the time of the current collections in Guinea-Conakry, the country had the lowest use of ITNs in Africa (President's Malaria Initiative, 2014), which provides the opportunity to monitor 2L+ a allele frequencies there as ITNs are rolled out.…”

Section: Discussionmentioning

confidence: 99%

The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

Riehle

Bukhari

Gnémé

et al. 2017

eLife

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Chromosome inversions suppress genetic recombination and establish co-adapted gene complexes, or supergenes. The 2La inversion is a widespread polymorphism in the Anopheles gambiae species complex, the major African mosquito vectors of human malaria. Here we show that alleles of the 2La inversion are associated with natural malaria infection levels in wild-captured vectors from West and East Africa. Mosquitoes carrying the more-susceptible allele (2L+a) are also behaviorally less likely to be found inside houses. Vector control tools that target indoor-resting mosquitoes, such as bednets and insecticides, are currently the cornerstone of malaria control in Africa. Populations with high levels of the 2L+a allele may form reservoirs of persistent outdoor malaria transmission requiring novel measures for surveillance and control. The 2La inversion is a major and previously unappreciated component of the natural malaria transmission system in Africa, influencing both malaria susceptibility and vector behavior.DOI: http://dx.doi.org/10.7554/eLife.25813.001

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“…sacharovi [89], and this is likely the case for An. gambiae as well [90]. Similarly, P450 mediated pyrethroid resistance does not incur a fitness cost in An.…”

Section: Pleiotropymentioning

confidence: 99%

“…Individuals carrying the 2La+/2La+ and 2La+/2La arrangements were able to survive exposure to dieldrin whilst those with the alternative 2La\2La arrangement could not, with only a few exceptions in CIG [81]. These data suggest that dieldrin resistance in these two colonies is continually maintained at a high level (phenotypic frequency of approximately 75%) by the continual maintenance of inversion 2La as a polymorphism [90]. Despite the effects of a fitness cost associated with dieldrin resistance in An.…”

Section: Pleiotropymentioning

confidence: 99%

Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

Brooke

Koekemoer

2010

Parasites Vectors

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Insecticide use in public health and agriculture presents a dramatic adaptive challenge to target and non-target insect populations. The rapid development of genetically modulated resistance to insecticides is postulated to develop in two distinct ways: By selection for single major effect genes or by selection for loose confederations in which several factors, not normally associated with each other, inadvertently combine their effects to produce resistance phenotypes. Insecticide resistance is a common occurrence and has been intensively studied in the major malaria vector Anopheles gambiae, providing a useful model for examining how insecticide resistance develops and what pleiotropic effects are likely to emerge as a consequence of resistance. As malaria vector control becomes increasingly reliant on successfully managing insecticide resistance, the characterisation of resistance mechanisms and their pleiotropic effects becomes increasingly important.

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Stable Chromosomal Inversion Polymorphisms and Insecticide Resistance in the Malaria Vector MosquitoAnopheles gambiae(Diptera: Culicidae)

Cited by 45 publications

References 76 publications

Revisiting the Impact of Inversions in Evolution: From Population Genetic Markers to Drivers of Adaptive Shifts and Speciation?

Revisiting the Impact of Inversions in Evolution: From Population Genetic Markers to Drivers of Adaptive Shifts and Speciation?

The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

Major effect genes or loose confederations? The development of insecticide resistance in the malaria vector Anopheles gambiae

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