Stable and unstable aberrations in lymphocytes of Chernobyl accident clearance workers carrying rogue cells

Ev, Domracheva; Rivkind, Nikolai; Асеева, Е. А.; Obukhova, Tatiana N.; D’achenko, L.V.; Vorobiov, A.I.

doi:10.1016/s0969-8043(00)00063-4

Cited by 12 publications

(5 citation statements)

References 20 publications

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“…Effective doses depend on the time of arrival in the contaminated territory and the duration of exposure Snigiryova et al, 1997. Numerous studies have found that in most cases, the liquidators were exposed to low doses of ionizing radiation [Sevan,kaev et al 1995;Snigiryova et al, 1997;Moor et al, 1999;Domracheva et al, 2000;Neronova et al, 2003;Maznik and Vinnikov, 2005;Shevchenko and Snigiryova, 2006]. The current model of a threshold-free action of low-dose ionizing radiation unambiguously postulates that any level of irradiation presents a hazard.…”

Section: Discussionmentioning

confidence: 66%

“…Examination of liquidators of the accident at the Chernobyl Nuclear Power Plant (ChNPP), either shortly after or many years following their irradiation, revealed increased levels of radiation-induced chromosome aberrations in their genomes as compared to unirradiated individuals [Sevan,kaev et al, 1995;Snigiryova et al, 1997;Moor et al, 1999;Domracheva et al, 2000;Neronova et al, 2003;Maznik and Vinnikov, 2005;Shevchenko and Snigiryova, 2006]. The possible genetic consequences of the ChNPP accident (hereditary and congenital malformations, spontaneous abortions, mortinatality) were estimated not to exceed 1% of the spontaneous rate [Bochkov and Chebotarev, 1989].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Aghajanyan

Кузьмина

Sipyagyna³

et al. 2011

Environ and Mol Mutagen

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Transgenerational genomic instability was studied in nonirradiated children born from fathers who were irradiated with low doses of ionizing radiation while working as clean-up workers at the Chernobyl Nuclear Power Plant (liquidators) and nonirradiated mothers from nuclear families. Aberrant cell frequencies (ACFs), chromosomal type aberration frequencies, and chromatid break frequencies (CBFs) in the lymphocytes of fathers-liquidators, and their children were significantly higher when compared with the control group (P < 0.05). Individual ACFs, aberration frequencies, and CBFs were independent of the time between irradiation of the father and conception of the child (1 month to 18 years). Chromosomes were categorized into seven groups (A through G). Analysis of aberrant chromosomes within these groups showed no differences in the average frequency of aberrant chromosomes between children and fathers-liquidators. However, significant differences were observed in the average frequency of aberrant chromosomes in groups A, B, and C between children and mothers in the families of liquidators. These results suggest that low doses of radiation induce genomic instability in fathers. Moreover, low radiation doses might be responsible for individual peculiarities in transgenerational genomic instability in children (as a consequence of response to primary DNA damage). Thus, genomic instability may contribute to increased morbidity over the lifetime of these children.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Aghajanyan

Кузьмина

Sipyagyna³

et al. 2011

Environ and Mol Mutagen

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“…According to some authors, their presence is associated with viral infection by the human polyoma virus JC and its replication [40]. The possibility of radiation effects, such as low-dose alpha radiation, cannot be ruled out [41], as this has been observed in newborns in the Indian state of Kerala, famous for its high natural radiation background, in uranium miners in Namibia, and in liquidators of the Chernobyl accident, and others [41–43]. …”

Section: Discussionmentioning

confidence: 99%

Chromosome analysis of nuclear power plant workers using fluorescence in situ hybridization and Giemsa assay

Hristova¹,

Hadjidekova²,

Grigorova³

et al. 2013

Journal of Radiation Research

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The aim of this study was to evaluate the genotoxic effects of ionizing radiation in vivo in exposed Bulgarian nuclear power plant workers by using classical cytogenetic and molecular cytogenetic analyses of peripheral lymphocytes. Chromosome analysis using fluorescence in situ hybrydization (FISH) and Giemsa techniques was undertaken on 63 workers and 45 administrative staff controls from the Bulgarian Nuclear Power Plant. Using the Giemsa method, the frequencies of cells studied with chromosome aberrations, dicentrics plus rings and chromosome fragments in the radiation workers were significantly higher compared with the control group (P = 0.044, P = 0.014, and P = 0.033, respectively). A significant association between frequencies of dicentrics plus rings and accumulated doses was registered (P < 0.01). In the present study, a FISH cocktail of whole chromosome paints for chromosomes 1, 4 and 11 was used. A significant association between frequency of translocations and accumulated doses was also observed (P < 0.001). Within the control group, a correlation was found between age and the spontaneous frequency of translocations. No correlation was found between smoking status and frequency of translocations. When compared with the control group, workers with accumulated doses up to 100 mSv showed no increase in genome translocation frequency, whereas workers with accumulated doses from 101 to 200 mSv showed a statistically significant doubling of genome translocation frequency (P = 0.009). Thus, in cases of chronic exposure and for purposes of retrospective dosimetry, the genome frequency of translocations is a more useful marker for evaluation of genotoxic effects than dicentric frequency.

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“…The examination of liquidators of the accident at the ChNPP, either shortly after or many years following their irradiation, revealed increased levels of radiation-induced chromosome aberrations in their genomes as compared to unirradiated individuals (Sevankaev et al 1995;Snigiryova et al 1997;Domracheva et al 2000;Neronova et al 2003;Maznik et al 2003;Shevchenko and Snigireva 2006). In liquidators, a significant increase in incidence of solid cancers (Kashcheev et al 2015) with a latent period between 4 and 15 years is described (Ivanov et al 2009a, b).…”

Section: Unirradiated Children Born From Irradiated Parentsmentioning

confidence: 99%

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

et al. 2016

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As children are more susceptible to ionizing radiation than adults, each nuclear accident demands special attention and care of this vulnerable population. The Chernobyl nuclear disaster occurred in a region populated with a large number of children, but despite all efforts and expertise of nuclear specialists, it was not possible to avoid casualties. As vast regions of Ukraine, Belarus and Russia were exposed to doses of ionizing radiation, which are known to be related with different diseases, shortly after the accident medical surveillance was launched, which also included analysis of genome damage. Child population affected by internal and external radiation consisted of subjects exposed prenatally, postnatally (both evacuated and non-evacuated), born by irradiated fathers who worked as liquidators, and parents exposed environmentally. In all groups of children during the last 30 years who were exposed to doses which were significantly higher than that recommended for general population of 1 mSv per year, increased genome damage was detected. Increased genome damage includes statistically higher frequency of dicentric and ring chromosomes, chromated and chromosome breaks, acentric fragments, translocations, and micronuclei. The presence of rogue cells confirmed internal contamination. Genome instability and radiosensitivity in children was detected both in evacuated and continuously exposed children. Today the population exposed to ionizing radiation in 1986 is in reproductive period of life and follow-up of this population and their offspring is of great importance. This review aims to give insight in results of studies, which reported genome damage in children in journals without language restrictions.

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Stable and unstable aberrations in lymphocytes of Chernobyl accident clearance workers carrying rogue cells

Cited by 12 publications

References 20 publications

Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Chromosome analysis of nuclear power plant workers using fluorescence in situ hybridization and Giemsa assay

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

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