Stabilized Compressed Nitroglycerin Tablets

Pharmacokinetics of Nitroglycerin in Rats

“…Intracardial ExDeriments-six rats were fasted overnight and aiven sublingual tablets can be stabilized effectively against volatilization by the inclusion of macromolecules such as povidone (8-10), polyethylene glycol (6), and microcrystalline cellulose (8,12).…”

Rapid and Accurate Stability-Indicating Assay for Nitroglycerin

“…Spectrophotometric methods require little instrumentation but are time consuming and complex and do not indicate stability (7)(8)(9)(10) or differentiate nitroglycerin, mononitroglycerin, dinitroglycerin, and endogenous nitrates. TLC (11-13) is selective but not quantitative.…”

Rapid Determination of Nitroglycerin Volatility Using Thermogravimetric Analysis

“…It is now well established that nitroglycerin stability can best be improved by reformulation of conventional molded tablets rather than by modifications in packaging materials. One approach toward this end has been the inclusion of various macromolecular substances in tablet formulations (3)(4)(5)(6)(7)9).From the experimental standpoint, the dependency of nitroglycerin stability in tablet formulations has been studied using extreme conditions of storage, i.e., completely exposing the tablets to air or to high vacuum, followed by chemical analysis of individual tablets. While studies of this type are of fundamental value in development work, they are generally time consuming when a large number of formulations is investigated.…”

“…It is now well established that nitroglycerin stability can best be improved by reformulation of conventional molded tablets rather than by modifications in packaging materials. One approach toward this end has been the inclusion of various macromolecular substances in tablet formulations (3)(4)(5)(6)(7)9).…”

“…It was found that thermogravimetric analysis affords a rapid and reliable means of evaluating the influence of various tablet components on the volatility of nitroglycerin. This report describes preliminary studies which ultimately led to the development of a stabilized compressed nitroglycerin tablet (9). EXPERIMENTAL Tablet Preparation-Nitroglycerin tablets, containing 0.6 mg of drug in each 30-mg tablet, were prepared using nitroglycerin spirit (9.1% w/v), alcohol USP, lactose (anhydrous) USP, starch USP, microcrystalline cellulose' NF, and calcium stearate NF.…”