Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis

Suresh, Veeraperumal; Anbazhagan, C.; Thangam, Ramar; Senthilkumar, Dharmaraj; Senthilkumar, N; Kannan, Soundarapandian; Rengasamy, Ramasamy; Palani, P.

doi:10.1016/j.carbpol.2012.10.038

Cited by 33 publications

(15 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is reported that a several environmental pollutants are believed to play a role in cancer development and DEN is one of such potent hepato‐carcinogen and is used in this investigation to induce HCC in the experimental animals (Suresh, et al, ). Fujise et al () found that HCC was associated with pronounced symptoms of weight loss (Fujise et al, ).…”

Section: Discussionmentioning

confidence: 99%

Hepato‐protective effects of R‐phycoerythrin‐rich protein extract ofPortieria hornemannii(Lyngbye) Silva against DEN‐induced hepatocellular carcinoma

Senthilkumar¹,

Thangam

Murugan

et al. 2018

J Food Biochem

Self Cite

View full text Add to dashboard Cite

The present investigation evaluates the hepato‐protective potential of R‐phycoerythrin (R‐PE)‐rich protein extract obtained from Portieria hornemannii (Lyngbye) Silva against H2O2‐induced hepatotoxicity using HepG2 cells (in vitro) and male Wistar albino Hepatocellular carcinoma (HCC) rats (in vivo). H2O2 treatment led to dose‐dependent decreases in cell viability of HepG2, which was ameliorated by the treatment with R‐PE‐rich extract. In vivo studies showed that all the vital parameters including enzymatic and nonenzymatic antioxidants as well as liver marker enzymes were affected in the experimentally induced HCC male Wistar rats upon exposure to the N‐diethylnitrosamine (DEN), a carcinogen. However, there was moderate to better restoration of such parameters in the carcinoma rats treated with R‐PE‐rich protein extract. Practical applications Therapeutic alternatives originating from food or food supplements are gaining popularity as “nutritional therapy” and they are well studied for their chemo‐preventive effects. Investigations of several food‐derived bioactive compounds revealed their ability to antagonize dysregulated targets in cellular signaling pathways to exhibit antineoplastic activities. Isolation of bioactive molecules present in marine food products and determination of their broad range pharmaceutical activity by means of deducing specific molecular targets as well as establishing minimal toxicity to normal tissues could aid in treatment of cancer. Phycobiliproteins are an important group of pigment molecules extracted from the red and blue green algae. A study was envisaged to evaluate the anticancer potential of RPERPE (R‐PE‐rich protein extract) obtained from P. hornemannii (Lyngbye) Silva against HCC using male Wistar albino rats as models. This study offers the scope of using the R‐PE‐rich protein extract of P.hornemannii for developing therapeutic anticancer formulation.

show abstract

Section: Discussionmentioning

confidence: 99%

Hepato‐protective effects of R‐phycoerythrin‐rich protein extract ofPortieria hornemannii(Lyngbye) Silva against DEN‐induced hepatocellular carcinoma

Senthilkumar¹,

Thangam

Murugan

et al. 2018

J Food Biochem

Self Cite

View full text Add to dashboard Cite

show abstract

“…Additional in vivo studies carried out in different models of colon, hepatocellular, sarcoma and leukemia cancer cells have also described positive effects for oral ingestion of fucoidans, although these were not from Fucus spp. origin [119,120,121]. …”

Section: Nutrient Composition Of Fucus Sppmentioning

confidence: 99%

Phycochemical Constituents and Biological Activities of Fucus spp.

2018

View full text Add to dashboard Cite

Seaweeds are known to be a good supply of key nutrients including carbohydrates, protein, minerals, polyunsaturated lipids, as well as several other health-promoting compounds capable of acting on a wide spectrum of disorders and/or diseases. While these marine macroalgae are deeply rooted in the East Asian culture and dietary habits, their major application in Western countries has been in the phycocolloid industry. This scenario has however been gradually changing, since seaweed consumption is becoming more common worldwide. Among the numerous edible seaweeds, members of the genus Fucus have a high nutritional value and are considered good sources of dietary fibers and minerals, especially iodine. Additionally, their wealth of bioactive compounds such as fucoidan, phlorotannins, fucoxanthin and others make them strong candidates for multiple therapeutic applications (e.g., antioxidant, anti-inflammatory, anti-tumor, anti-obesity, anti-coagulant, anti-diabetes and others). This review presents an overview of the nutritional and phytochemical composition of Fucus spp., and their claimed biological activities, as well as the beneficial effects associated to their consumption. Furthermore, the use of Fucus seaweeds and/or their components as functional ingredients for formulation of novel and enhanced foods is also discussed.

show abstract

“…Fucoidan was found to prevent diethylnitrosamine-induced hepatocarcinogenesis by inhibiting metabolic activation of the carcinogen [30]. Takeda et al found that oral administration of fucoidan effectively inhibited growth of implanted Sarcoma-180 cells in xenograft mouse models [31].…”

Section: In Vivo Anticancer Effectsmentioning

confidence: 99%

“…This fucoidan-induced alteration in antioxidant activity might lead to increased levels of striatal dopamine and its metabolite, increased expression of tyrosine hydroxylase, and reduced behavioral deficits. Suresh et al demonstrated that fucoidan prevented increase of drug-metabolizing hepatic enzyme levels, which result from oxidative stress by diethylnitrosamine, a carcinogen in rats [30]. In contrast, splenocytes of fucoidan-treated mice infected with Leishmania donovani generated significantly high levels of superoxide and NO [65].…”

Section: In Vivo Antioxidant and Prooxidant Effects Of Fucoidanmentioning

confidence: 99%

Fucoidan as a Marine Anticancer Agent in Preclinical Development

2014

View full text Add to dashboard Cite

Fucoidan is a fucose-containing sulfated polysaccharide derived from brown seaweeds, crude extracts of which are commercially available as nutritional supplements. Recent studies have demonstrated antiproliferative, antiangiogenic, and anticancer properties of fucoidan in vitro. Accordingly, the anticancer effects of fucoidan have been shown to vary depending on its structure, while it can target multiple receptors or signaling molecules in various cell types, including tumor cells and immune cells. Low toxicity and the in vitro effects of fucoidan mentioned above make it a suitable agent for cancer prevention or treatment. However, preclinical development of natural marine products requires in vivo examination of purified compounds in animal tumor models. This review discusses the effects of systemic and local administration of fucoidan on tumor growth, angiogenesis, and immune reaction and whether in vivo and in vitro results are likely applicable to the development of fucoidan as a marine anticancer drug.

show abstract

Stabilization of mitochondrial and microsomal function of fucoidan from Sargassum plagiophyllum in diethylnitrosamine induced hepatocarcinogenesis

Cited by 33 publications

References 55 publications

Hepato‐protective effects of R‐phycoerythrin‐rich protein extract ofPortieria hornemannii(Lyngbye) Silva against DEN‐induced hepatocellular carcinoma

Hepato‐protective effects of R‐phycoerythrin‐rich protein extract ofPortieria hornemannii(Lyngbye) Silva against DEN‐induced hepatocellular carcinoma

Phycochemical Constituents and Biological Activities of Fucus spp.

Fucoidan as a Marine Anticancer Agent in Preclinical Development

Contact Info

Product

Resources

About