Stabilization of indocyanine green dye in polymeric micelles for NIR-II fluorescence imaging and cancer treatment

Yeroslavsky, Gil; Umezawa, Masakazu; Okubo, Kyohei; Nigoghossian, Karina; Dung, Doan Thi Kim; Miyata, Keiji; Kamimura, Masao; Soga, Kohei

doi:10.1039/c9bm02010a

Cited by 49 publications

(32 citation statements)

References 45 publications

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“…In addition, several other fluorescent compounds even suggest their potentials as novel anti-CSC agents [19,20]. For these fluorescent dyes, simultaneous cancer targeting, imaging, and cancer killing are a major advantage for cancer biology research and are expected to contribute to the future cancer therapy directions including photodynamic therapy (PDT) [21][22][23]. Furthermore, several specific membrane molecules targeting cancer cells have already been used in the in vivo NIR photoimmunotherapy field [24].…”

Section: Introductionmentioning

confidence: 99%

A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production

Zhang

Liu

Bai

et al. 2021

Bioinorganic Chemistry and Applications

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Development of multiple agents has a significant impact on the cancer diagnosis and therapy. Several fluorescent dyes including near-infrared (NIR) fluorescent agents have been already well studied in the field of photodynamic therapy (PDT). In the present study, we reported a novel fluorescent dye could obviously inhibit cancer cell proliferation with slight toxic effects on the biological organism. Furthermore, it displayed selective staining on cancer cells, particularly on cancer stem cells (CSCs), rather than normal cells. Mechanically, this dye preferred to invading mitochondria of cancer cells and inducing overwhelming reactive oxygen species (ROS) production. The in vivo experiments further demonstrated that this dye could image cancer cells and even CSCs in a short-time intratumor injection manner using a zebrafish model and subsequently inhibit cancer cell proliferation after a relatively long-time drug exposure. Taken together, the future development of this agent will promise to make an essential contribution to the cancer diagnosis and therapeutics.

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Section: Introductionmentioning

confidence: 99%

A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production

Zhang

Liu

Bai

et al. 2021

Bioinorganic Chemistry and Applications

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“…As emphasized in Table 1 ,

is used as a counter anion in IR-1040, IR-1048, and IR-1061 ( Figure 1 c,d). Among them, IR-1061 has been embedded in a variety of nanostructures such as polymeric micelles and solid nanoparticles and used for biophotonic applications [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Thinking about why such heavy anions are coordinated with the NIR organic dyes gives a hint on selecting proper surroundings in organic/inorganic hybrid nanostructures.…”

Section: Design Basics Of Near Infrared Fluorescent Nanostructurementioning

confidence: 99%

Near Infrared Fluorescent Nanostructure Design for Organic/Inorganic Hybrid System

Okubo¹,

Umezawa²,

Soga³

2021

Biomedicines

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Near infrared (NIR) light offers high transparency in biological tissue. Recent advances in NIR fluorophores including organic dyes and lanthanide-doped inorganic nanoparticles have realized the effective use of the NIR optical window for in vivo bioimaging and photodynamic therapy. The narrow energy level intervals used for electronic transition that involves NIR light, however, give rise to a need for guidelines for reducing heat emission in luminescence systems, especially in the development of organic/inorganic hybrid structures. This review presents an approach for employing the polarity and vibrational energy of ions and molecules that surround the luminescence centers for the development of such hybrid nanostructures. Multiphonon relaxation theory, formulated for dealing with heat release in ionic solids, is applied to describe the vibrational energy in organic or molecular systems, referred to as phonon in this review, and we conclude that surrounding the luminescence centers either with ions with low vibrational energy or molecules with small chemical polarity is the key to bright luminescence. NIR photoexcited phosphors and nanostructures in organic/inorganic mixed systems, designed based on the guidelines, for photodynamic therapy are reviewed.

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“…NIR imaging of tumors in mice using affibody functionalized CH1055 was also conducted [40]. More recently, our group and several others found that a commercially available dye, indocyanine green (ICG), the only NIR dyes that are approved by the Food and Drug Administration (FDA) for clinical use in humans, with an emission peak of 830 nm can be used to NIR fluorescence imaging in the second NIR window [41].…”

Section: Nir Molecular Probesmentioning

confidence: 99%

Development of Molecular Imaging Probe for Dual NIR/MR Imaging

Dung

Umezawa

Nigoghossian

et al. 2020

J. Photopol. Sci. Technol.

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Imaging utilizing the near-infrared (NIR) light has attracted numerous attention due to the possibility in the deep tissue penetration as it can overcome the light scattering and absorption of tissue components. The ultraviolet (UV) unlikely penetrates the skin, while the visible (VIS) light can be scattered or absorbed by tissue components. This penetration likely improves as the wavelength shifts beyond 1000 nm region (also called NIR-II). Fat tissues are ascribed to the scattering of UV or VIS, while others such as water, melanin, hemoglobin are greatly attributed to absorbing light. Using NIR over 1000 nm (OTN-NIR) is currently considered as a critical approach for real-time dynamical visualization of the structure and functional features of tissues anatomically with refrained effects of fatty scattering and water absorption. However, the attempts to image anatomical structure by OTN-NIR is laborious and time-consuming. Then, for facile human applying, magnetic resonance imaging (MRI) is used as a guiding technique to localize the sites of interest. MRI is considered the most beneficial imaging technique without ionizing radiation which provides images with high resolution, preeminent tissue contrast. MRI also can visualize a large volume such as the human body to the few millimeter objects with great signal-to-noise ratio as well as contrastto-noise ratio. This review highlights the design of imaging probe for multimodal NIR/MR imaging, including the potential applications.

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Stabilization of indocyanine green dye in polymeric micelles for NIR-II fluorescence imaging and cancer treatment

Abstract: Encapsulation of ICG and IR-1061 in PCL–PEG micelles producing agents with increased stability of ICG and tunable PTT and PDT activity. The micelles are also useful for NIR imaging and NIR nanothermometry.

Cited by 49 publications

References 45 publications

A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production

A Novel Fluorescent Dye Invades Mitochondria to Selectively Kill Cancer Stem Cells via Increased ROS Production

Near Infrared Fluorescent Nanostructure Design for Organic/Inorganic Hybrid System

Development of Molecular Imaging Probe for Dual NIR/MR Imaging

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