Stabilization of Autoxidizable Materials by Means of Inclusion<sup>1</sup>

Schlenk, Hermann; Sand, Donald M.; Tillotson, Jerry Ann

doi:10.1021/ja01618a049

Cited by 51 publications

(21 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saturated and unsaturated fatty acids (UFA) were the first examples of this protection [78]. There is a masking action against oxygen diffusion and restricted accessibility to the included guest molecule may be involved.…”

Section: Protection Against Light and Oxidationmentioning

confidence: 99%

Luminescence in organized media and supramolecular interactions:physicochemical aspects and applications

Lerner¹,

Martín²

2000

Analusis

View full text Add to dashboard Cite

Introduction Molecular luminescence of analytes in organized media or in supramolecular complexes of cyclodextrinsThe photophysical and photochemical behaviour of molecules complexed to cyclodextrins (CD) is generally different from their behaviour in solution. The first observations in the field were qualitative and were related to the increased stabilisation of labile molecules, mostly drugs, against photodegradation when complexed to natural cyclodextrins [1]. Complexation by CD's was then the preferred subject for those involved in supramolecular chemistry and drug vectorisation techniques [2] as well as in separation techniques [3][4][5]. Stabilization of a molecule against photochemical degradation is still very important in the field of pharmaceutical sciences. A recent example is the stabilisation of promazine as an inclusion complex with β-cyclodextrin [6]. Other photochemists were attracted quite early to this field of research and initiated studies, which were mostly photophysical in nature [7,8]. The key observation was that the formation of supramolecular complexes of analytes with cyclodextrins (CDs) resulted in an increase of their fluorescence quantum yield or even in the appearance of room temperature phosphorescence (RTP) [9][10][11][12]. This enhancement has been used to increase the sensitivity and the selectivity in both luminescence and chromatographic techniques [13-15].We will not say more about RTP with CDs as the subject will be developed in another contribution in the same issue of this Journal. However RTP is also observed in the solubilization of analytes in micellar colloïdal solutions and this field will be reviewed hereunder.These properties have been used to develop analytical techniques, which combine the selectivity of complexation with an enhanced emission [16][17][18][19]. In this way an improvement in the detection limits is obtained in many separation techniques such as HPLC, capillary electrophoresis (CE) or planar chromatography. Furthermore these molecular interactions allow to reveal or to stabilize new molecular forms or to turn species which are normally non-emitting into luminescent ones. All these aspects are reviewed hereunder after a short summary on the nature of the intermolecular interactions, which lie at the heart of these effects. Nature of the interactions between an analyte and a CD or a micelleWithout going into a thorough analysis of the origin of the interactions which exist between molecules in dense media which concern us here, it seems useful to recall the most important factors which should be taken into account when any type of luminescence, fluorescence or phosphorescence is involved.

show abstract

Section: Protection Against Light and Oxidationmentioning

confidence: 99%

Luminescence in organized media and supramolecular interactions:physicochemical aspects and applications

Lerner¹,

Martín²

2000

Analusis

View full text Add to dashboard Cite

show abstract

“…In T. utilis grown in the presence of equimolar amounts of methionine and ethionine, the SAM/SAE ratio in the cell was2/1 (167).…”

Section: Activation Of Ethioninementioning

confidence: 99%

Toxic Amino Acids: Their Action as Antimetabolites

Fowden¹,

Lewis²,

Tristram³

1967

Advances in Enzymology - And Related Areas of Molecular Biology

View full text Add to dashboard Cite

“…The study of hydratation of beta cyclodextrin (flCD) was previously reported [4]. The first preparation of an inclusion complex between cholesterol and flCD was pulished by Schlenk [5], although a convincing proof of the existence of the complex was not given. Recently Claudy et al [6] and Fridrich et aL …”

Section: Introductionmentioning

confidence: 99%

Physicochemical characterization of cholesterol-beta cyclodextrin inclusion complexes

Cloudy

Létoffé

Germain

et al. 1991

Journal of Thermal Analysis

View full text Add to dashboard Cite

Study and characterization of molecular complexes between cholesterol and beta cyclodextrin has been done using X-ray diffraction, thermogravimetric analysis (TG), differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy (a3C NMR). Whatever the value of the molar ratio cholesterol/flCD used during the preparation, the same compound is always obtained. Corresponding to a molar ratio 1/3 (cholesterol/-flCD), this compound is a stable hydrate which, contrary to flCD, contains at room temperature a large amount of molecules of water. It can be dehydrated under low pressure but the thermal degradation occurs at 200~ (250~ for flCD). This implies that cholesterol is strongly bounded to flCD.

show abstract

Stabilization of Autoxidizable Materials by Means of Inclusion¹

Cited by 51 publications

References 0 publications

Luminescence in organized media and supramolecular interactions:physicochemical aspects and applications

Luminescence in organized media and supramolecular interactions:physicochemical aspects and applications

Toxic Amino Acids: Their Action as Antimetabolites

Physicochemical characterization of cholesterol-beta cyclodextrin inclusion complexes

Contact Info

Product

Resources

About

Stabilization of Autoxidizable Materials by Means of Inclusion1

Cited by 51 publications

References 0 publications

Luminescence in organized media and supramolecular interactions:physicochemical aspects and applications

Luminescence in organized media and supramolecular interactions:physicochemical aspects and applications

Toxic Amino Acids: Their Action as Antimetabolites

Physicochemical characterization of cholesterol-beta cyclodextrin inclusion complexes

Contact Info

Product

Resources

About

Stabilization of Autoxidizable Materials by Means of Inclusion¹