Stabilization of Aerosolizable Nano-carriers by Freeze-Drying

Packhaeuser, Claudia B.; Lahnstein, Kerstin; Sitterberg, Johannes; Schmehl, Thomas; Gessler, Tobias; Bakowsky, Udo; Seeger, Werner; Kissel, Thomas

doi:10.1007/s11095-008-9714-0

Cited by 33 publications

(16 citation statements)

References 40 publications

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“…Vibrating‐mesh nebulizers can also successfully deliver poorly water‐soluble drugs to the lungs from dispersed systems, such as nanosuspensions . The drug particle size of nanosuspensions can be maintained for this particular aerosolization, including nanoparticles prepared using freeze‐drying with different lyoprotectants . Active vibrating‐mesh nebulizers have shown to present superior aerosolization performance compared to a passive vibrating‐mesh system when tested with a suspension of nondeformable, latex microspheres, although incurring in particle fragmentation .…”

Section: Established Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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Objectives In this review paper, we explore the interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations for several types of devices, namely jet, ultrasonic and vibrating-mesh nebulizers; colliding and extruded jets; electrohydrodynamic mechanism; surface acoustic wave microfluidic atomization; and capillary aerosol generation. Key findings Nebulization is the transformation of bulk liquids into droplets. For inhalation therapy, nebulizers are widely used to aerosolize aqueous systems, such as solutions and suspensions. The interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations plays a significant role in the performance of aerosol generation appropriate for pulmonary delivery. Certain types of nebulizers have consistently presented temperature increase during the nebulization event. Therefore, careful consideration should be given when evaluating thermo-labile drugs, such as protein therapeutics. We also present the general approaches for characterization of nebulizer formulations. Summary In conclusion, the interplay between the dosage form (i.e. aqueous systems) and the specific type of device for aerosol generation determines the effectiveness of drug delivery in nebulization therapies, thus requiring extensive understanding and characterization.

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Section: Established Nebulizersmentioning

confidence: 99%

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

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“…Crosslinking Lactose is disaccharides carbohydrate where according to Packheuser et al at 5% concentration resulted physical characteristics of stable microspheres [11]. Maltodextrin is selected because as the potential lyoprotectants on protein lyophilisation [12], Fig 1 and 2 show obvious bonds indicated some functional groups of maltodextrin and lactose.…”

mentioning

confidence: 99%

Effect of Lactose and Maltodextrin on The Physical Characteristics of Ovalbumin-loaded Alginate Microspheres Produced By Aerosolization

Hariyadi¹,

Purwanti²,

Nirmala³

2014

PsycEXTRA Dataset

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“…If, for example, the registered force is stronger than it should be, the piezoelectric transducer moves the tip away from the specimen surface and vice versa. Since the voltage applied to the z-piezo changes in accordance with the topography of the Particle surface morphology (Götzinger and Peukert, 2003;Hooton et al, 2006a;Packhaeuser et al, 2009;Ward et al, 2005) …”

Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

“…To date, lactose tends to be the carrier material of choice-but researchers (Hooton et al, 2006b;Kaialy et al, 2011Kaialy et al, , 2010Nokhodchi, 2012, 2013a,b;Packhaeuser et al, 2009) are working towards the use of sugar based substitutes such as mannitol, raffinose, trehalose, xylitol and cyclodextrin; novel materials such as polymer nano-carriers (Paranjpe and Müller-Goymann, 2014); and the development of carrier free formulations (Healy et al, 2014). AFM has been used to evaluate the morphology of freeze-dried mannitol, a promising carrier species (Packhaeuser et al, 2009).…”

Section: Topographical Imagingmentioning

confidence: 99%

Characterisation of dry powder inhaler formulations using atomic force microscopy

Weiss

McLoughlin

Cathcart

2015

International Journal of Pharmaceutics

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A B S T R A C TInhalation formulations are a popular way of treating the symptoms of respiratory diseases. The active pharmaceutical ingredient (API) is delivered directly to the site of action within the deep lung using an inhalation device such as the dry powder inhaler (DPI).The performance of the formulation and the efficiency of the treatment depend on a number of factors including the forces acting between the components. In DPI formulations these forces are dominated by interparticulate interactions. Research has shown that adhesive and cohesive forces depend on a number of particulate properties such as size, surface roughness, crystallinity, surface energetics and combinations of these. With traditional methods the impact of particulate properties on interparticulate forces could be evaluated by examining the bulk properties. Atomic force microscopy (AFM), however, enables the determination of local surface characteristics and the direct measurement of interparticulate forces using the colloidal probe technique. AFM is considered extremely useful for evaluating the surface topography of a substrate (an API or carrier particle) and even allows the identification of crystal faces, defects and polymorphs from high-resolution images. Additionally, information is given about local mechanical properties of the particles and changes in surface composition and energetics. The assessment of attractive forces between two bodies is possible by using colloidal probe AFM.This review article summarises the application of AFM in DPI formulations while specifically focussing on the colloidal probe technique and the evaluation of interparticulate forces.2015 Elsevier B.V. All rights reserved.

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Stabilization of Aerosolizable Nano-carriers by Freeze-Drying

Abstract: Freeze-drying with LPA is a suitable method to physically stabilize fast-degrading NC from aqueous suspensions without influencing the aerosolizability.

Cited by 33 publications

References 40 publications

The function and performance of aqueous aerosol devices for inhalation therapy

The function and performance of aqueous aerosol devices for inhalation therapy

Effect of Lactose and Maltodextrin on The Physical Characteristics of Ovalbumin-loaded Alginate Microspheres Produced By Aerosolization

Characterisation of dry powder inhaler formulations using atomic force microscopy

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