Stabilization of Acne Vulgaris-Associated Microbial Dysbiosis with 2% Supramolecular Salicylic Acid

Bilal, Hazrat; Xiao, Yuanyuan; Khan, Muhammad Nadeem; Chen, Jinyu; Wang, Qian; Zeng, Yuebin; Lin, Xinyu

doi:10.3390/ph16010087

Cited by 9 publications

(12 citation statements)

References 37 publications

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“…Hazrat Bilal et al 13 . found that the total lesion count and global acne grading system (GAGS) score reduced significantly (p < 0.001) compared to the control group, after treatment with 2% SSA hydrogel.…”

Section: Discussionmentioning

confidence: 99%

“…This results in water-soluble SSA which has the properties of slow release upon application, efficiency in low-pH, and low skin irritation. 6,7 Hazrat Bilal et al 13 found that the total lesion count and global acne grading system (GAGS) score reduced significantly (p < 0.001) compared to the control group, after treatment with 2% SSA hydrogel. They also found that α diversity index was increased and β diversity was stabilized significantly (p < 0.001) compared to the control group, due to the treatment with 2% SSA hydrogel.…”

Section: Discussionmentioning

confidence: 99%

“…12 And 2% SSA could normalize the microbial communities associated with the skin in acne vulgaris patients. 13 Various concentration of SA has been used for different dermatological condition and also cosmetics. The concentration at which the anti-inflammatory action of SA is most pronounced is between 0.5% and 5% (w/w).…”

Section: Discussionmentioning

confidence: 99%

“…Zhou et al demonstrated that topical 0.5%–5% supramolecular SA hydrogel did no harm to normal murine skin and upregulated the expression of genes related to the epidermal barrier in 28‐day using 12 . And 2% SSA could normalize the microbial communities associated with the skin in acne vulgaris patients 13 . Lu et al found that acne vulgaris treatment with SA might be associated with the regulation of SREBP‐1 pathway and NF‐κB pathway in human SEB‐1 sebocytes 14 …”

Section: Discussionmentioning

confidence: 99%

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2% supramolecular salicylic acid hydrogel vs. adapaline gel in mild to moderate acne vulgaris treatment: A multicenter, randomized, evaluator‐blind, parallel‐controlled trial

Ye,

Yi,

et al. 2024

J of Cosmetic Dermatology

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ObjectiveSalicylic acid (SA) has been used for treatment of acne of different severity levels. However, there are few researches about the safety and efficacy for treatment of mild to moderate acne, and the improvement of the skin condition by using 2% supramolecular salicylic acid (SSA) compared to Davuwen Adapaline gel.MethodsA multicenter, randomized, assessor‐blind and parallel‐controlled study was conducted. A total of 500 patients (trial group: 249, control group: 251) with mild to moderate (grade I–II) facial acne vulgaris were recruited in this study over a 16‐week trial period. Patients in the trial group were treated with Broda 2% SSA hydrogel, while control group treated with Davuwen Adapaline gel once a day. The number of inflammatory papules, comedones, and pustules were counted and the rate of lesion reduction was calculated pre‐ and post‐treatment. Then, the skin physiological indicators, including L*a*b*, TEWL, skin sebum and hydration were measured. Statistical analysis was conducted using SAS 9.4. Significance was set at p = 0.05.ResultsAt the end of 12 weeks' therapy, the regression and markedly improvement rate of the trail group and the control group were 51.01% and 43.10% respectively, and there was no significant difference in the improvement rate between two groups (p = 0.0831). Although, there was no difference in adverse events rate between two groups, the adverse events rate of the trail group was 0.40%, a little lower than the control group (0.80%). Moreover, there was a significant difference in the numbers of pores at T1 between two groups.ConclusionBoth 2% SSA and Adapaline gel were equally effective in the treatment of mild to moderate acne vulgaris. 2% SSA is worth the clinical promotion and application in mild to moderate acne vulgaris.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

2% supramolecular salicylic acid hydrogel vs. adapaline gel in mild to moderate acne vulgaris treatment: A multicenter, randomized, evaluator‐blind, parallel‐controlled trial

Ye,

Yi,

et al. 2024

J of Cosmetic Dermatology

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show abstract

“…Numerous over-the-counter drugs are available for acne treatments, which majorly contain salicylic acid [ 54 ]. Supramolecular Salicylic Acid treatment significantly improved the acne patients and modulates the microbial diversity of patients toward like individuals with no facial acne [ 55 ]. Niacinamide: Niacinamide is a form of vitamin B3 called nicotinamide (composed of niacin/nicotinic acid).…”

Section: Conventional Medications For Acne Treatmentmentioning

confidence: 99%

Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances

Vasam,

Korutla,

Bohara

2023

Biochemistry and Biophysics Reports

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Correlation between the facial skin microbiome and sensitive skin using the 2bRAD‐M technique

Lu,

Cheng,

Shi

2024

Intern J of Cosmetic Sci

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ObjectiveThis study aimed to expound on the correlation between facial skin microbiome and sensitive skin (SS) using a novel sequencing technique.MethodsWe applied the 2bRAD sequencing for the microbiome, which enables accurate characterization of the low‐biomass microbiome at species resolution to profile facial skin microbes in SS and non‐SS groups. Further, the bacterial colonies were isolated and cultured from skin surfaces to study the pro‐inflammatory effect on human keratinocytes by ELISA.ResultsWe accordingly identified 1142 genera and 4436 strains. In the SS group, the proportions of Actinomyces and Microbotryomycetes were significantly increased, whereas that of Acidimicrobiia was decreased. Kruskal–Wallis analysis revealed significant differences in 11 genera and 35 species, among which the proportions of Dermabacter, Chryseobacterium, Rhodotorula and Peptoniphilus A were increased in the SS group. Analysis of the top 10 genera revealed increased proportions of Cutibacterium, Corynebacterium and Staphylococcus. Moreover, the proportion of Dermabacter hominis was significantly increased by 18.9‐fold in the SS group, whereas those of many Streptococcus strains were significantly decreased. Focus on the isolated bacterial colonies from skin surfaces, more yellow colonies were found in SS group when cultured in Tryptic Soy Broth medium for 48 h, and more interleukin‐8 was detected on keratinocytes after yellow colonies stimulation, such as S.capitis, M.luteus.ConclusionsThis study suggests that more SS‐associated microorganisms can be identified using the 2bRAD technique even with a small sample size. Dermabacter hominis and Chryseobacterium was firstly reported with a significantly increase in SS, and the S.capitis, as well as M.luteus, but not S.aureus, may be associated with skin inflammation.

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Stabilization of Acne Vulgaris-Associated Microbial Dysbiosis with 2% Supramolecular Salicylic Acid

Cited by 9 publications

References 37 publications

2% supramolecular salicylic acid hydrogel vs. adapaline gel in mild to moderate acne vulgaris treatment: A multicenter, randomized, evaluator‐blind, parallel‐controlled trial

2% supramolecular salicylic acid hydrogel vs. adapaline gel in mild to moderate acne vulgaris treatment: A multicenter, randomized, evaluator‐blind, parallel‐controlled trial

Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances

Correlation between the facial skin microbiome and sensitive skin using the 2bRAD‐M technique

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