Stabilization of a percutaneously implanted port catheter system for hepatic artery chemotherapy infusion

Shindoh, Noboru; Ozaki, Yuka; Kyogoku, Shinsuke; Yamana, Daigo; Sumi, Yukiharu; Katayama, Hitoshi

doi:10.1007/s002709900404

Cited by 20 publications

(9 citation statements)

References 6 publications

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“…anesthesia [5,6,15]; however, the recent development of interventional techniques has made it possible to implant port-catheter systems percutaneously under local anesthesia [3,4,7,8,9,10,11,12,13,14,16,17]. Thus, attention has come to be paid to hepatic arterial infusion chemotherapy which can be performed repeatedly at the outpatient clinic via a percutaneously implanted portcatheter system for patients with advanced liver cancer as one effective treatment from the point of view of prolonging normal-quality survival [2].…”

Section: Discussionmentioning

confidence: 99%

Catheter-tip fixation of a percutaneously implanted port-catheter system to prevent dislocation

et al. 2001

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The aim of this study was to evaluate the incidence of catheter tip dislocation in patients with percutaneously implanted port-catheters for hepatic arterial chemotherapy with catheter tip fixation. Forty-seven patients (31 men and 16 women; mean age 66 years) with unresectable advanced liver cancers (primary liver cancer, n=19; metastatic liver cancer, n=28) underwent percutaneously implantable port-catheter system placement with the tip fixed at the gastroduodenal artery with coils and side hole opened at the common hepatic artery. In 39 patients, n-butyl cyanoacrylate (NBCA) mixed with Lipiodol was added for fixation. The position of the side hole after the indwelling port-catheter system was investigated, and the correction method in cases with catheter dislocation was determined. In 2 (25%) of the 8 patients without NBCA fixation, dislocation of the catheter was noted, in contrast to none (0%) of 37 patients with NBCA fixation. Two patients in whom NBCA was used could not undergo long-term intra-arterial chemotherapy because of hepatic arterial thrombotic occlusion which occurred after placement of the indwelling catheter, and were excluded from the evaluation. Fixation of the catheter tip with combined use of coils and NBCA--Lipiodol mixture to the gastroduodenal artery is important to prevent dislocation of the port-catheter system.

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Section: Discussionmentioning

confidence: 99%

Catheter-tip fixation of a percutaneously implanted port-catheter system to prevent dislocation

et al. 2001

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“…To avoid gastrointestinal mucosal injury due to anticancer agents, the arteries supplying the gastrointestinal tract were occluded by metallic coils. The gastroduodenal artery (GDA)‐fixed method was first considered for the catheter placement . Briefly, a 4‐Fr heparin‐coated catheter was placed and the tip of the catheter was located in the gastroduodenal artery and fixed by the metallic coils, with the side hole of the catheter located at the common hepatic artery .…”

Section: Methodsmentioning

confidence: 99%

Neutrophil/lymphocyte ratio as a prognostic indicator of hepatic arterial infusion chemotherapy with arterial cisplatin plus continuous 5‐fluorouracil

Tajiri

Kawai

Minemura

et al. 2014

Hepatology Research

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“…A 5-Fr heparin-coated catheter was placed and the tip of the catheter was located in the gastroduodenal artery and fixed by the metallic coils. The side hole of the catheter was located at the common hepatic artery (GDA-fixed method) [10]. Another tip of the catheter was connected to the injection port system and implanted in a subcutaneous pocket in the right inguinal part in front of the femoral region.…”

Section: Methodsmentioning

confidence: 99%

Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma

Ueshima¹,

Kudo²,

Takita³

et al. 2010

Oncology

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Background: Although hepatic arterial infusion chemotherapy (HAIC) using low-dose 5-fluorouracil (5-FU) and cisplatin (low-dose FP) is commonly used for advanced hepatocellular carcinoma (HCC) with vascular invasion in Japan, few reports have investigated the efficacy and safety of this approach. We investigated the efficacy and toxicity of HAIC using low-dose FP for patients with advanced HCC as a phase II trial. Methods: Low-dose FP consisted of a continuous arterial infusion of 5-FU (250–500 mg/day, 5 days/week, for the first 2 weeks) and cisplatin (10 mg/day, 5 days/week, for the first 2 weeks). Then, 5-FU (1,000 mg/body for 5 h) and cisplatin (10 mg/body) were administered once weekly. Results: In these patients treated with low-dose FP, the response rate was 38.5%, the median time to progression was 4.1 months (95% CI 2.1–6.1 months) and the median survival time was 15.9 months (95% CI 9.8–22.0 months). The most frequent adverse events were myelosuppression such as neutropenia or thrombocytopenia. Conclusions: HAIC using low-dose FP is an effective treatment option for locally advanced HCC. However, it is not well tolerated hematologically because of potent pancytopenia and poor hepatic reserve. Therefore, this regimen should be performed carefully with regular monitoring of hematological function.

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Stabilization of a percutaneously implanted port catheter system for hepatic artery chemotherapy infusion

Cited by 20 publications

References 6 publications

Catheter-tip fixation of a percutaneously implanted port-catheter system to prevent dislocation

Catheter-tip fixation of a percutaneously implanted port-catheter system to prevent dislocation

Neutrophil/lymphocyte ratio as a prognostic indicator of hepatic arterial infusion chemotherapy with arterial cisplatin plus continuous 5‐fluorouracil

Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma

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