Stabilization for loop isomers of c-myc G-quadruplex DNA and anticancer activity by ruthenium complexes

Liu, Ying; Liu, Yanan; Yang, Licong; Cao, Chengwen; Zhou, Yanhui; Liu, Jie

doi:10.1039/c4md00201f

Cited by 11 publications

(17 citation statements)

References 33 publications

(32 reference statements)

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“…Other examples of NP structure simplification (truncation) in drug discovery [166] include the first oral disease-modifying drug fingolimod, which was approved for the treatment of multiple sclerosis in 2010, as well as the antihepatitis drug bicyclol, which was approved in P. R. China in 2004 ( Figure 34). These compounds were developed by simplification of the naturally occurring antibiotic myriocin( isolated from thermophilic fungi Mycelia sterilia), [167] ands chizandrin C( isolated from Fructus Schizandrae), [168] respectively.M oreover,i tw as suggestedt hat nearly all synthetic drugs acting on the central nervouss ystem could be considered as simplified variationso fN Ps. [169] It should also be noted that the simplification (truncation) methodology is relatedt oo ther strategies, namely,D TS and FOS, as discussed in sections 3.4.3 and 3.4.4, respectively.…”

Section: Simplification (Truncation) Of Np Structuresmentioning

confidence: 99%

The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

Grygorenko

Volochnyuk

Ryabukhin

et al. 2019

Chemistry A European J

125

123

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All pharmaceutical products contain organic molecules; the source may be a natural product or a fully synthetic molecule, or a combination of both. Thus, it follows that organic chemistry underpins both existing and upcoming pharmaceutical products. The reverse relationship has also affected organic synthesis, changing its landscape towards increasingly complex targets. This Review article sets out to give a concise appraisal of this symbiotic relationship between organic chemistry and drug discovery, along with a discussion of the design concepts and highlighting key milestones along the journey. In particular, criteria for a high‐quality compound library design enabling efficient virtual navigation of chemical space, as well as rise and fall of concepts for its synthetic exploration (such as combinatorial chemistry; diversity‐, biology‐, lead‐, or fragment‐oriented syntheses; and DNA‐encoded libraries) are critically surveyed.

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Section: Simplification (Truncation) Of Np Structuresmentioning

confidence: 99%

The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

Grygorenko

Volochnyuk

Ryabukhin

et al. 2019

Chemistry A European J

125

123

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“…TCP is the major metabolite of the insecticides chlorpyrifos and chlorpyrifos-methyl, as well as trichlopyr herbicide [51]. Since TCP is rapidly excreted in human urine after exposure to chlorpyrifos, it has been used as a biomarker for exposure [31,39,49,51,[52][53][54][55][56][57][58]. In Lin's group, a portable immunochromatographic strip-based biosensor for direct detection TCP in human saliva sample was developed ( Figure 3) [54].…”

Section: Measurement Of Metabolitesmentioning

confidence: 99%

“…A Teflon gasket with a flow channel was mounted between the SPE and the cover to form a flow cell, in which the SPE was exposed to the cell for the electrochemical detection ( Figure 4B). Flowinjection analysis with amperometric detection offers the possibility of real-time and continuous-flow detection of toxic compounds within environmental or biological samples, using very small volumes (< 20 mL) or highthroughput analysis of numerous samples (3600 injections/ h) [52,74,75]. Du et al [47] developed a strategy where phosphorylated AChE was reactivated to enable measurement of both inhibited and baseline ChE activity in the same sample.…”

Section: Assay Of Cholinesterase Activitymentioning

confidence: 99%

Nanomaterial Based Biosensors for Detection of Biomarkers of Exposure to OP Pesticides and Nerve Agents: A Review

et al. 2017

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Organophosphorus (OP) pesticides are primarily used as insecticides and chemical warfare agents worldwide. Due to their impact on the environment and health, it is important to develop prompt and accurate pesticide analysis method. This review addresses recent advances and new trends in nanotechnology‐based biosensors for biological monitoring of exposures to OP pesticides and nerve agents. In order to determine them, we have to find the corresponding biomarkers. In 1989, the national academy of sciences (NAS)divided biomarkers into the following three categories: biomarker of exposure, biomarker of effect and biomarker of susceptibility (Figure 1A). The unique chemical and physical properties of nanomaterial have paved the way to new and improved sensing devices, in general, and electrochemical/optical biosensors, in particular. In this paper, background information and a general overview of electrochemical/immunoassay detection techniques are provided. Various nanomaterial labels are discussed. Usually nanomaterials can be roughly divided into nanometer powder, nanometer fiber, nanometer film, nanometer block and so on four classes, such as colloidal gold, semiconductor nanoparticles and carbon nanomaterial (Figure 1B). In addition, we discuss some future considerations and opportunities for advancing the use of biosensors for environmental and health studies.

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“…Therefore, the oncogene c-myc G-quadruplex DNA as a potential target for antitumor drugs has received increased attention. Up to now, a number of ruthenium(II) complexes have been reported to effectively bind to, induce and stabilize c-myc G-quadruplex DNA [11,[20][21][22][23][24][25][26][27]. Zhang However, among the ruthenium(II) complexes reported, limited investigations are focused on the binuclear complexes.…”

Section: Introductionmentioning

confidence: 99%

Induction of C-Myc G-Quadruplex Dna and Cytotoxicity of a Calix[]arene-Containing Binuclear Ruthenium(ii) Complex

Wang

Yan

et al. 2019

J. Chil. Chem. Soc.

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Herein, a binuclear ruthenium(II) complex modified by calix[4]arene group has been prepared. The complex as potential inducer and stabilizer of c-myc Gquadruplex DNA and antitumor reagent were studied. Observations revealed that the complex could bind to c-myc Pu27 and Pu22 DNA strongly with constants of 1.18 × 10 7 (Pu27) and 4.13 × 10 6 M-1 (Pu22) via groove mode as determined from absorption and luminescence titrations, as well as CD spectra. Results of continuous variation analysis confirmed that the complex interacted with c-myc G-quadruplex DNA through a 1:1 binding stoichiometry. As verified by PCR-stop assay, the replication of c-myc DNA was effectively blocked by the complex with the complete inhibition at the complex concentration of 4.0 μM both for Pu27 and Pu22, suggesting that the complex could efficiently induce the formation of c-myc G-quadruplex DNA. The appearance of blue TMB solution in the visual experiment also proved that the sequences of Pu27 and Pu22 could fold into G-quadruplex under the induction of the complex. Nevertheless, the complex was found to exhibit weak stabilization ability on c-myc G-quadruplex DNA according to FRET assay, which increased the melting point of c-myc DNA only 3-3.5 °C. The experiments on Topoisomerase inhibition and cytotoxicity of the complex showed that it acted as an inhibitor of TopoI and exhibited moderate anticancer activity against MCF-7 and Huh-7 tumor cells.

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Stabilization for loop isomers of c-myc G-quadruplex DNA and anticancer activity by ruthenium complexes

Cited by 11 publications

References 33 publications

The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

Nanomaterial Based Biosensors for Detection of Biomarkers of Exposure to OP Pesticides and Nerve Agents: A Review

Induction of C-Myc G-Quadruplex Dna and Cytotoxicity of a Calix[]arene-Containing Binuclear Ruthenium(ii) Complex

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