Stabilization and encapsulation of human immunoglobulin G into biodegradable microspheres

Wang, Jianjun; Chua, Kay Ming; Wang, Chi-Hwa

doi:10.1016/j.jcis.2003.08.072

Cited by 90 publications

(50 citation statements)

References 42 publications

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“…Hence, the 'active' and 'total' release profiles may be compared and the integrity of the released protein may be assessed. In the same way, the three-dimensional conformation may be analyzed by Size Exclusion Chromatography-HPLC (SEC-HPLC) (Wang et al, 2004), Sodium Dodecyl Sulfate-Poly Acrylamide Gel Electrophoresis (SDS-PAGE) (Woo et al, 2001), Circular Dichroism (CD) (Kwon et al, 2004) and Fourier Transform Infrared Spectroscopy (FTIR) (Carrasquillo et al, 2001).…”

Section: Influence Of the Sampling Methodsmentioning

confidence: 99%

“…The burst effect is generally attributed to the rapid diffusion of the drug located at the surface of the microparticles. Many studies (Pean et al, 1999;Lam et al, 2001;Perez et al, 2003;Wang et al, 2004;Kim et al, 2005) and reviews (Schwendeman et al, 1996;Wang et al, 1999;Burke et al, 2000;van de Weert et al, 2000;Perez et al, 2002;Bilati et al, 2005;Tamber et al, 2005;Wang et al, 2005) have addressed protein stability issues occurring during the formulation process. However, few results have shown a suitable protein release profile.…”

Section: Introductionmentioning

confidence: 99%

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How to achieve sustained and complete protein release from PLGA-based microparticles?

Giteau

Venier-Julienne

Aubert-Pouëssel

et al. 2008

International Journal of Pharmaceutics

234

184

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One of the most challenging tasks in the delivery of therapeutic proteins from PLGAbased microparticles is the sustained and complete release of the protein in its native form.The mechanisms responsible for incomplete protein release from these devices are numerous and complex; the beneficial effect of different formulations has often been evaluated in vitro.Strategies employed for overcoming protein destabilization during the release step are reviewed in this paper. Proteins have been protected in the deleterious environment by adding stabilizers to the formulation, or by modifying the protein or the polymer. Alternatively, some strategies have aimed at avoiding the formation of the destabilizing environment. As experimental conditions may influence the results from in vitro release studies, we initially report precautions to avoid adverse effects.

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Section: Influence Of the Sampling Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

How to achieve sustained and complete protein release from PLGA-based microparticles?

Giteau

Venier-Julienne

Aubert-Pouëssel

et al. 2008

International Journal of Pharmaceutics

234

184

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“…Table 1 summarizes the most frequently used materials for the synthesis of materials in particulate form, and also includes the methods for production of these systems and intended applications, with a brief description of the most widely used groups following the table. (Herrmann and Bodmeier, 1998;Cruaud et al, 1999;Abazinge et al, 2000;Lam et al, 2000;Perez et al, 2002;De Rosa et al, 2003;Perugini et al, 2003;Jollivet et al, 2004;Wang et al, 2004;Norton et al, 2005) Release (Isobe et al, 1996;Yamazaki et al, 1996;Isobe et al, 1999;Walter et al, 1999;King and Patrick, 2000;Kim and Park, 2001;Ain et al, 2002;Hedberg et al, 2002;Murillo et al, 2002;Zhu et al, 2002;Diwan and Park, 2003;Jalón et al, 2003;…”

Section: Materials Used In the Synthesis Of Materials In Particulate mentioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

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“…We have previously shown that proteins encapsulated under a nanosolid state within a PLGA polymer preserve their structure and integrity, allowing a better and prolonged release profile and the maintenance of their biological activity . In order to optimize the preparation of small peptides, various methods like spraydrying or spray-freeze drying have been reported (Lam et al, 2000;Wang et al, 2004). Even 380 if these methods can generate protein particles, they have several disadvantages, such as the complexity of the technique, leading to low protein recovery and, above all, they may denature proteins.…”

Section: Discussionmentioning

confidence: 99%

Nanoprecipitated catestatin released from pharmacologically active microcarriers (PAMs) exerts pro-survival effects on MSC

Angotti

Venier-Julienne

Penna

et al. 2017

International Journal of Pharmaceutics

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Catestatin (CST), a fragment of Chromogranin-A, exerts angiogenic, arteriogenic, vasculogenic and cardioprotective effects. CST is a very promising agent for revascularization purposes, in "NO-OPTION" patients. However, peptides have a very short half-life after administration and must be conveniently protected. Fibronectin-coated 30 pharmacologically active microcarriers (FN-PAM), are biodegradable and biocompatible polymeric microspheres that can convey mesenchymal stem cell (MSCs) and therapeutic proteins delivered in a prolonged manner. In this study, we first evaluated whether a small peptide such as CST could be nanoprecipitated and incorporated within FN-PAMs.

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Stabilization and encapsulation of human immunoglobulin G into biodegradable microspheres

Cited by 90 publications

References 42 publications

How to achieve sustained and complete protein release from PLGA-based microparticles?

How to achieve sustained and complete protein release from PLGA-based microparticles?

Materials in particulate form for tissue engineering. 1. Basic concepts

Nanoprecipitated catestatin released from pharmacologically active microcarriers (PAMs) exerts pro-survival effects on MSC

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