Stability studies on nifedipine tablets using thermogravimetry and differential scanning calorimetry

Filho, R. O. C.; Franco, P. I. B. M.; Conceição, Edemilson Cardoso da; Leles, Maria Inês Gonçalves

doi:10.1007/s10973-007-8791-3

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…This study is useful in noting that heat or freezing does not cause any immediate degradation, but because of its very short time frame it is not applicable to most cases that this question is considering, where drugs used by EMS units or expeditions would undoubtedly be exposed to uncontrolled environments for far longer than 48 h at a time. 17…”

Section: Discussionmentioning

confidence: 99%

“…An accelerated study of nifedipine tablets placed in amber glass containers at 75% RH and 40°C for 180 d showed no degradation products on differential scanning calorimetry and thermogravimetry. 18…”

Section: Discussionmentioning

confidence: 99%

“…15 An accelerated study of nifedipine tablets placed in amber glass containers at 75% RH and 40˚C for 180 d showed no degradation products on differential scanning calorimetry and thermogravimetry. 18 Returned capsules of nifedipine 10 mg, 19 mo postexpiry, contained 101% API with no degradation products. The results suggest this agent is stable after expiry after storage in an uncontrolled environment.…”

Section: Nifedipinementioning

confidence: 99%

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Expired Drugs in the Remote Environment

Browne

Peeters

Priston

et al. 2019

Wilderness & Environmental Medicine

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Introduction-The British Antarctic Survey Medical Unit works in a very remote area of the world, with several Antarctic bases receiving only a single annual resupply of consumable goods. Pharmaceuticals supplied in this manner will often be approaching or past the end of their nominal shelf life before the following year's resupply. Drugs are transported from the UK via ship; the hold is not temperature controlled, and the ship crosses through the tropics (air temperature 25À30˚C for approximately 3 wk). The drugs then must be transported from the ship to the base, often in temperatures substantially below freezing. This study assessed the stability of 5 expired drugs (atropine, nifedipine, flucloxacillin, naproxen, and bendroflumethiazide) returned from Antarctic bases. Methods-Drugs were opportunistically obtained and tested using stability-indicating assays. Results-All tested drugs were stable. Conclusions-The results suggest that the studied drugs may be stable beyond expiry, even when not maintained in strictly temperature-controlled conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%