Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment

Abstract

Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully formulated buccal mucoadhesive polymer films, which contained cetirizine-hydrochloride (CTZ) as the API. The present study focused on investigating the stability and permeability of the prepared films. The stability of the films was studied with an accelerated stability test. During the stability test, thickness, breaking hardness and in vitro mucoadhesivity were analysed. Furthermore, the interactions were studied with FT-IR spectroscopy, and the changes in the amount of the API were also monitored. Cytotoxicity and cell line permeability studies were carried out on TR 146 buccal cells. Compositions that can preserve more than 85% of the API after 6 months were found. Most of the compositions had a high cell viability of more than 50%. Citric acid (CA) decreased the stability and reduced every physical parameter of the films. However, cell line studies showed that the permeability of the films was enhanced. In our work, we successfully formulated CTZ-containing buccal films with adequate stability, high cell viability and appropriate absorption properties.

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

“…This temperature-responsive hydrogel showed sustained drug release, antibacterial activity, and non-toxicity. The fabrication of ALG/CL-based delivery systems is constantly developed [ 155 ], as evidenced by the work on the application of microfibrillated cellulose-reinforced alginate microbeads for vitamin E delivery [ 156 ], cellulose nanofibril/sodium alginate hydrogels for ibuprofen delivery [ 157 ] or ALG/hydroxymethyl CL buccal films for allergy treatment [ 158 ].…”

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

“…Processes 2023, 11, 2628 2 of 19 Oral films can be orodispersible films (fast-dissolving oral films or oral dissolving films-ODF) [33][34][35][36][37][38][39][40][41][42][43][44][45] and mucoadhesive buccal films (MBF) [46][47][48][49][50][51][52][53]. The ODFs are formulated for rapid drug release and subsequent absorption in the oral cavity or digestive tract [54][55][56].…”