Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E

Segall, Adriana Inés; Moyano, María Alejandra

doi:10.1111/j.1468-2494.2008.00473.x

Cited by 32 publications

(28 citation statements)

References 11 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It can also induce collagen synthesis and suppress the pigmentation of the skin while reducing signs of photoaging. However, it is chemically unstable, and it can easily be oxidized; therefore, more stable derivatives of ascorbic acid such as ascorbyl palmitate, ascorbyl tetraisopalmitate, and magnesium ascorbyl phosphate are widely used in pharmaceutical industry (1,2). These derivatives can easily be converted to the active compound, ascorbic acid, after ingestion.…”

Section: Introductionmentioning

confidence: 99%

Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery

et al. 2010

View full text Add to dashboard Cite

Abstract. L-ascorbic acid has been widely used in cosmetic and dermatological products because of its ability to scavenge free radicals and destroy oxidizing agents. However, it is chemically unstable and can easily be oxidized. The current cosmetic facial masks available in the market are pre-moistened, which means that the aqueous fluid content of the mask may oxidize some of the unstable active ingredients such as ascorbic acid. This work presents an anti-wrinkle nanofiber face mask containing ascorbic acid, retinoic acid, gold nanoparticles, and collagen. This novel face mask will only be wetted when applied to the skin, thus enhancing product stability. Once moistened, the content of the mask will gradually dissolve and release the active ingredients and ensure maximum skin penetration. The high surface areato-volume ratio of the nanofiber mask will ensure maximum contact with the skin surface and help to enhance the skin permeation to restore its healthy appearance. Electrospun fiber mats may provide an attractive alternative to the commercial facial cotton masks.

show abstract

Section: Introductionmentioning

confidence: 99%

Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery

et al. 2010

View full text Add to dashboard Cite

show abstract

“…We have developed a novel ascorbic acid-peptide conjugate in which a peptide is linked with L-ascorbic acid via a succinoyl linker. The increased stability of our conjugate may be attributed to not only the phosphate in the L-ascorbic acid ring (leading to the stabilization of the double bond in the ring), but also the peptide-specific hydrogen bonding of the conjugate (12). Given that the compound described is non-cytotoxic and stable, as shown in Fig.…”

Section: Discussionmentioning

confidence: 99%

“…To overcome these problems, there are some alternatives, including modification with several fatty acid-bound complexes or treatment with a mixture of zinc sulfate and L-tyrosine with L-ascorbic acid, and L-ascorbate-2-phosphate. It remains necessary to explain the mode of action of these treatments (12,13). For these reasons, the development of stabilized ascorbic acid is important.…”

Section: Discussionmentioning

confidence: 99%

A novel L-ascorbic acid and peptide conjugate with increased stability and collagen biosynthesis

Choi¹,

Park²,

Kim³

et al. 2009

BMB Reports

View full text Add to dashboard Cite

L-ascorbic acid (Vitamin C) and peptide are both useful compounds for collagen biosynthesis in cosmeceuticals (cosmetic and pharmaceutical fields). The instability of these compounds, however, limit their application in these industries. In this report, we describe the development of a novel compound, Stabilized Ascorbyl Pentapeptide (SAP), which physically is much more stable than L-ascorbic acid in water. The inhibitory effects of this SAP compound on tyrosinase and melanin synthesis is comparable to that of L-ascorbic acid. Importantly, the SAP compound displays no cytotoxicity at a high concentration (5 mM). The ability of SAP to promote collagen biosynthesis is greater than that of L-ascorbic acid or the KTTKS peptide alone. Considering the in vitro stability and functional effects, our data strongly suggest that the SAP compound is a good candidate not only as a cosmetic ingredient, but also as a wound healing agent. [BMB reports 2009; 42(11): 743-746]

show abstract

“…Vitamin C possesses a high antioxidative activity, thus reducing oxidative stress in human skin [5], suppresses pigmentation of the skin and decomposition of melanin [6], stimulates collagen production [7][8][9] and regenerates vitamin E and ubiquinol [10,11]. Topical application of vitamin C has been shown to significantly elevate cutaneous levels of this vitamin, which correlates with protection of the skin from both UVB (290-320 nm) and UVA (320-400 nm) induced damages as measured by erythema and sunburn cell formation [12].…”

Section: Normalized Concentration Of Beta-carotenementioning

confidence: 99%

“…The excitation laser light was transferred through the optical fiber (2) and focused onto the investigated sample (cuvette with the cosmetic formulation) (3). Appropriated Stokes Raman scattering light, corresponding to carbon-carbon double-bond stretch vibrations of the conjugated backbone of beta-carotene molecule (wave number 1525 cm À1 ), was transferred to a spectrometer (5) and measured at 527.2 nm by a CCD camera (6). Then, the obtained spectrum was analyzed on a computer (7) and the intensity of the appropriated peak was determined.…”

Section: Resonance Raman Spectroscopymentioning

confidence: 99%

Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations

Darvin

Sterry

Lademann

2009

Journal of Biophotonics

View full text Add to dashboard Cite

Carotenoids beta-carotene, lutein, lycopene and others are well-known powerful antioxidants acting as an effective neutralizer of free radicals produced in the human organism as a result of the influence of stress factors, such as UV irradiation. The protective effect of antioxidants is used in cosmetic products to increase the skin protection against the destructive action of free radicals and for the stabilization of formulations against oxidation. In the skin, the different antioxidant substances form protection chains to avoid their destruction by the interaction with the free radicals. Similar effects have to be expected also in topically applied formulations. In the present study the influence of different mixtures of antioxidants (beta-carotene, vitamins C and E) on the stability of antioxidants in formulations used for skin treatment was investigated. The measurements were carried out by using non-invasive resonance Raman spectroscopy for the detection of the carotenoid concentration in the cosmetic formulations.

show abstract

Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E

Cited by 32 publications

References 11 publications

Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery

Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery

A novel L-ascorbic acid and peptide conjugate with increased stability and collagen biosynthesis

Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations

Contact Info

Product

Resources

About