Stability of Three Cephalosporin Antibiotics in AutoDose Infusion System Bags

Stability of Commonly Used Antibiotic Solutions in an Elastomeric Infusion Device

“…Previously published studies for cefazolin, [15][16][17][18][19][20][21] ceftazidime, 7,18,20,22 ceftriaxone, 6,18,20,[23][24][25][26] clindamycin, 17,21,[26][27][28] and vancomycin 8,[29][30][31] all reported stability data and expiration dates that were in general agreement with the results reported here. In some cases, the recommended expiry dates in those previously studies were longer than those determined in the current study, largely because the beyond-use dates calculated here were based on 95% CIs, whereas 95% CIs were not calculated in most of the earlier studies.…”

“…[6][7][8][15][16][17][18][19][20][21][22][23][24][26][27][28][29][30] Previously published studies often used only linear regression to calculate the percent remaining on the last study day. The time to reach 90% of the initial concentration (T-90%) can be calculated on the basis of the observed concentration remaining as reported in previous publications [6][7][8][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] and compared to the T-90% determined for each drug in the current study (Table 7, Figure 1). Calculation of T-90% yields a better overall estimate of expiry date because it minimizes the effect of study duration and day-to-day variability in the estimates of concentration.…”

Stability Test of Ampicillin Sodium Solutions in the Accufuser® Elastomeric Infusion Device Using HPLC: UV Method

“…To be suitable for self-administration by home-based patient, the antibiotic should be stable in the peritoneal dialysis solution for a number of days under home storage conditions [1]. Therefore, it is necessary to determine the physical and chemical stabilities of the admixtures in the infusion system before they appear in the clinical settings [2][3][4][5][6][7][8]. The purpose of this study is to provide such information with commonly used antibiotic solutions, Ampicillin sodium, into Accufuser saline, NS and sterile water, SW) packed in sterile Accufuser ® device were evaluated, in which each samples were stored and evaluated at appropriate intervals up to 7 days under different storage conditions (room temperature, RT, 25˚C ± 2˚C and cold temperature, CT, 4˚C ± 2˚C).…”

“…The purpose of this study is to provide such information with commonly used antibiotic solutions, Ampicillin sodium, into Accufuser saline, NS and sterile water, SW) packed in sterile Accufuser ® device were evaluated, in which each samples were stored and evaluated at appropriate intervals up to 7 days under different storage conditions (room temperature, RT, 25˚C ± 2˚C and cold temperature, CT, 4˚C ± 2˚C). The study was done with Ampicillin sodium solutions which were made with NS and SW since these are the most available infusion solutions for Ampicillin sodium administrations in clinical situations [1,6,9].…”

Chemical Stability of Ceftriaxone by a Validated Stability-Indicating Liquid Chromatographic Method

“…The official method for quantitative determination of ceftriaxone is ion-pair liquid chromatography with UV detection 16 . Also, there are few studies related with stability studies of ceftriaxone diluted with different solutions (sterile water, sodium chloride injection, dextrose injection, lidocaine hydrochloride injection) [17][18][19][20][21][22] . In these methods were not demonstrated the stability-indicating capability of the assay and/or were not sufficiently validated.…”