2014
DOI: 10.1128/jvi.03351-13
|View full text |Cite
|
Sign up to set email alerts
|

Stability of the Parainfluenza Virus 5 Genome Revealed by Deep Sequencing of Strains Isolated from Different Hosts and following Passage in Cell Culture

Abstract: The strain diversity of a rubulavirus, parainfluenza virus 5 (PIV5), was investigated by comparing 11 newly determined and 6 previously published genome sequences. These sequences represent 15 PIV5 strains, of which 6 were isolated from humans, 1 was from monkeys, 2 were from pigs, and 6 were from dogs. Strain diversity is remarkably low, regardless of host, year of isolation, or geographical origin; a total of 7.8% of nucleotides are variable, and the average pairwise difference between strains is 2.1%. Varia… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

4
67
0

Year Published

2015
2015
2023
2023

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 42 publications
(71 citation statements)
references
References 44 publications
(67 reference statements)
4
67
0
Order By: Relevance
“…These unencapsidated DI-RNAs may be the doublestranded RNA that elicits innate immune responses in negativestrand RNA virus infections. ADAR1 A-to-I editing has also been documented in full-length RNA virus genomes (33,34,60,61) and was recently inferred by deep sequencing analyses of several paramyxoviruses (62,63).…”
Section: Discussionmentioning
confidence: 99%
“…These unencapsidated DI-RNAs may be the doublestranded RNA that elicits innate immune responses in negativestrand RNA virus infections. ADAR1 A-to-I editing has also been documented in full-length RNA virus genomes (33,34,60,61) and was recently inferred by deep sequencing analyses of several paramyxoviruses (62,63).…”
Section: Discussionmentioning
confidence: 99%
“…CPiV belongs to the family Paramyxoviridae, subfamily Rubulavirinae, comprising also distantly related human parainfluenza viruses 2 and 4, and mumps virus (reviewed by Ellis and Krakowa, 2012;ICTV, 2018). Although the virus is generally still referred to as CPiV in veterinary medicine, the correct nomenclature evolved from 'parainfluenza virus 5' (Rima et al, 2014) to 'mammalian orthorubulavirus 5', and this name is consistent with the isolation of the virus from various mammals, including man and dogs (ICTV, 2018). The virus is highly contagious and therefore endemic worldwide.…”
Section: Biology and Pathophysiology Of Pathogens In Cirdcmentioning
confidence: 99%
“…Hypermutation has been related to posttranscriptional editing by host adenosine deaminases of viral genomes from persistent infections of other RNA viruses such as measles virus (Cattaneo and Billeter 1992), human parainfluenza virus (Murphy et al 1991;Rima et al 2014), and respiratory syncytial viruses (Rueda et al 1994). In these studies, the estimated mutation frequencies of U → C or A → G transitions were in the range of 3.3 × 10 −2 to 1.0 × 10 −1 mutations per nucleotide.…”
Section: Arenavirus Hypermutationmentioning
confidence: 99%