Stability of Some Hypothesized Psychological Determinants of Fertility Control

Quereshi, M. Y.

doi:10.2466/pr0.1998.82.2.657

Cited by 1 publication

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“…ALC increases the energy status of the cell by increasing the activities of cytochrome b oxidase, thus maintaining energy levels of the cells and stabilizing mitochondrial activity [42]. This evidence confirms the ALC cytoprotective role.…”

Section: Cytochrome B Oxidasementioning

confidence: 61%

Cytoprotective Effect of Acetyl-l-Carnitine Evidenced by Analysis of Gene Expression in the Rat Brain

et al. 2009

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Acetyl-L-carnitine (ALC), the acetyl ester of L-carnitine, is a naturally occurring substance that when administered at supraphysiological concentrations is neuroprotective. ALC plays an essential role in intermediary and mitochondrial metabolism. It has also neurotrophic and antioxidant actions. ALC has demonstrated efficacy and high tolerability in the treatment of neuropathies of various etiologies, and it is a molecule of considerable interest for its clinical application in various neural disorders, such as Alzheimer's disease and painful neuropathies, although little is known regarding the effects of ALC on gene expression. Suppression subtractive hybridization methodology was used for the generation of subtracted complementary DNA libraries and the subsequent identification of differentially expressed transcripts in the rat brain after a chronic ALC treatment. In the present paper, we provide evidences for the up-regulation of the expression of prostaglandin D(2) synthase, brain-specific Na(+)-dependent inorganic phosphate transporter, and cytochrome b oxidase, bc1 complex induced in the rat brain by ALC. On the contrary, ALC treatment down-regulates the expression of the gene of ferritin-H. Altogether, these results suggest that ALC might play a cytoprotective role against various brain stressors.

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Section: Cytochrome B Oxidasementioning

confidence: 61%