Stability of silicones modified with PEO-silane amphiphiles: Impact of structure and concentration

Ngo, Bryan Khai D.; Lim, Kendrick K; Stafslien, Shane J.; Grunlan, Melissa A.

doi:10.1016/j.polymdegradstab.2019.03.010

Cited by 10 publications

(20 citation statements)

References 40 publications

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“…In fact, when PEO is utilized to the surface of model substrates with physically stable (e.g., silicon [ 74 , 75 ], glass [ 76 ], and gold [ 77 ]), protein resistance has been established. In this case, the silicone resin can be directly grafted and batch modified, and the PEO chain can be stably maintained on the film surface, which is independent of environmental changes (air or water) [ 78 ].…”

Section: Physicochemical Modification Of the Membrane Surfacementioning

confidence: 99%

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

Wang

et al. 2021

Adv Compos Hybrid Mater

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Since extracorporeal membrane oxygenator (ECMO) has been utilized to save countless lives by providing continuous extracorporeal breathing and circulation to patients with severe cardiopulmonary failure. In particular, it has played an important role during the COVID-19 epidemic. One of the important composites of ECMO is membrane oxygenator, and the core composite of the membrane oxygenator is hollow fiber membrane, which is not only a place for blood oxygenation, but also is a barrier between the blood and gas side. However, the formation of blood clots in the oxygenator is a key problem in the using process. According to the study of the mechanism of thrombosis generation, it was found that improving the hemocompatibility is an efficient approach to reduce thrombus formation by modifying the surface of materials. In this review, the corresponding modification methods (surface property regulation, anticoagulant grafting, and bio-interface design) of hollow fiber membranes in ECMO are classified and discussed, and then, the research status and development prospects are summarized. Graphical abstract

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Section: Physicochemical Modification Of the Membrane Surfacementioning

confidence: 99%

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

Wang

et al. 2021

Adv Compos Hybrid Mater

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“…However, in prior studies, an analogous assay with unmodified silicone resulted in HF adsorption ≈400 ng cm −2 . [50] This indicates that, from a simple protein solution, HF adsorption is very low for the unmodified PU and may not allow for differences to be observed with PEO-SA modified PUs. Thus, further assessment against a complex biological fluid such as blood was needed.…”

Section: Resultsmentioning

confidence: 99%

“…As SMAs in such a silicone, they showed effective and sustained water-driven surface restructuring for enhanced hydrophilicity and resistance to protein adsorption ( Figure 1b). [46,47,50] As this was not observed with analogous, nonamphiphilic PEO-silanes [(α-(EtO) 3 -Si-(CH 2 ) 3 -PEO n -CH 3 )], [48,50,52] the unique restructuring capacity of PEO-SAs was attributed to the flexibility and chemical compatibility of the ODMS tether with the silicone matrix. Additional studies evaluated concentration (0-100 µmol per 1 g of silicone) as well as the structure-property relationship of PEO-SAs of different PEO length (n; n = 3-16), [52,53] ODMS length (m; m = 0-30), [48] and crosslinkability (i.e., with or without TES group).…”

Section: Introductionmentioning

confidence: 94%

“…[45,46] Our group has developed PEO-silane amphiphile (PEO-SA) SMAs, originally for the bulk-modification of condensation-cure silicones. [46][47][48][49][50][51][52][53] The PEO-SA contains a triethoxysilane (TES) group, a flexible, hydrophobic oligo(dimethyl siloxane) (ODMS) tether, and a PEO segment: (Figure 1a). [49] The TES group is capable of crosslinking when incorporated into a condensation-cure silicone.…”

Section: Introductionmentioning

confidence: 99%

“…Additional studies evaluated concentration (0-100 µmol per 1 g of silicone) as well as the structure-property relationship of PEO-SAs of different PEO length (n; n = 3-16), [52,53] ODMS length (m; m = 0-30), [48] and crosslinkability (i.e., with or without TES group). [46,50] Generally, PEO-SA SMAs demonstrated increased surface hydrophilicity and resistance to human fibrinogen (HF) adsorption (from a simple aqueous solution) at concentrations as low as 10 µmol g −1 . Furthermore, both a crosslinkable (m = 13, n = 8) and non-crosslinkable (m = 30, n = 8) variant could similarly sustain these properties with minimal water uptake and SMA leaching following aqueous conditioning (Figure 1c,d).…”

Section: Introductionmentioning

confidence: 99%

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Thromboresistance of Polyurethanes Modified with PEO‐Silane Amphiphiles

Ngo

Lim

Johnson

et al. 2020

Macromolecular Bioscience

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Surface‐induced thrombosis is problematic in blood‐contacting devices composed of silicones or polyurethanes (PUs). Poly(ethylene oxide)‐silane amphiphiles (PEO‐SA) are previously shown effective as surface modifying additives (SMAs) in silicones for enhanced thromboresistance. This study investigates PEO‐SAs as SMAs in a PU at various concentrations: 5, 10, 25, 50, and 100 µmol g−1 PU. PEO‐SA modified PUs are evaluated for their mechanical properties, water‐driven surface restructuring, and adhesion resistance against a human fibrinogen (HF) solution as well as whole human blood. Stability is assessed by monitoring hydrophilicity, water uptake, and mass loss following air‐ or aqueous‐conditioning. PEO‐SA modified PUs do not demonstrate plasticization, as evidenced by minimal changes in glass transition temperature, modulus, tensile strength, and percent strain at break. These also show a concentration‐dependent increase in hydrophilicity that is sustained following air‐ and aqueous‐conditioning for concentrations ≥25 µmol g−1. Additionally, water uptake and mass loss are minimal at all concentrations. Although protein resistance is not enhanced versus an HF solution, PEO‐SA modified PUs have significantly reduced protein adsorption and platelet adhesion from human blood at concentrations ≥10 µmol g−1. Overall, this study demonstrates the versatility of PEO‐SAs as SMAs in PU, which leads to enhanced and sustained hydrophilicity as well as thromboresistance.

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Role of dynamic surface tension of silicone polyether surfactant-based silicone coatings on protein adsorption: An insight on the ‘ambiguous’ interfacial properties of Fouling Release Coatings

Soriano-Jerez,

Gourlaouen,

Zeriouh

et al. 2024

Progress in Organic Coatings

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Stability of silicones modified with PEO-silane amphiphiles: Impact of structure and concentration

Cited by 10 publications

References 40 publications

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

Thromboresistance of Polyurethanes Modified with PEO‐Silane Amphiphiles

Role of dynamic surface tension of silicone polyether surfactant-based silicone coatings on protein adsorption: An insight on the ‘ambiguous’ interfacial properties of Fouling Release Coatings

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