Stability of Rift Valley fever virus at 4 C.

Craig, D E; Thomas, WJ; DeSanctis, Armand N.

doi:10.1128/aem.15.2.446-447.1967

Cited by 7 publications

(3 citation statements)

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“…Aborted foetal materials and placental membranes contain large numbers of virus particles which can either contaminate the local environment directly or infect animals in close contact. The RVFV may persist for relatively long periods in the environment as has been demonstrated during in vitro experiments [ 9 , 49 , 257 ].…”

Section: Pathogenesis and Immune Responsesmentioning

confidence: 99%

Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention

et al. 2010

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Rift Valley fever (RVF) virus is an arbovirus in the Bunyaviridae family that, from phylogenetic analysis, appears to have first emerged in the mid-19th century and was only identified at the begininning of the 1930s in the Rift Valley region of Kenya. Despite being an arbovirus with a relatively simple but temporally and geographically stable genome, this zoonotic virus has already demonstrated a real capacity for emerging in new territories, as exemplified by the outbreaks in Egypt (1977), Western Africa (1988) and the Arabian Peninsula (2000), or for re-emerging after long periods of silence as observed very recently in Kenya and South Africa. The presence of competent vectors in countries previously free of RVF, the high viral titres in viraemic animals and the global changes in climate, travel and trade all contribute to make this virus a threat that must not be neglected as the consequences of RVF are dramatic, both for human and animal health. In this review, we present the latest advances in RVF virus research. In spite of this renewed interest, aspects of the epidemiology of RVF virus are still not fully understood and safe, effective vaccines are still not freely available for protecting humans and livestock against the dramatic consequences of this virus.

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Section: Pathogenesis and Immune Responsesmentioning

confidence: 99%

Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention

et al. 2010

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“…Previous studies have reported ex vivo stability from other Bunyaviruses, particularly the survival of Hantaviruses in cell-free media [41,42]. Other examples include Sandfly Fever Sicilian Virus (SFSV), a sandfly-borne virus; Crimean-Congo Haemorrhagic Fever Virus (CCHV), transmitted by ticks; and RVFV, which can be transmitted by mosquitoes [43][44][45][46]. The epidemiological relevance of extracellular stability is that it alters the route of transmission and risks associated with the handling of infected animals or contaminated waste.…”

Section: Discussionmentioning

confidence: 99%

Comparative characterization of the reassortant Orthobunyavirus Ngari with putative parental viruses, Bunyamwera and Batai: in vitro characterization and ex vivo stability

Dutuze

Mayton

Macaluso

et al. 2021

Journal of General Virology

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Bunyamwera (BUNV), Batai (BATV) and Ngari (NRIV) are mosquito-borne viruses that are members of the genus Orthobunyavirus in the order Bunyavirales. These three viruses are enveloped with single-stranded, negative-sense RNA genomes consiting of three segments, denoted as Small (S), Medium (M) and Large (L). Ngari is thought to be the natural reassortant progeny of Bunyamwera and Batai viruses. The relationship between these ‘parental’ viruses and the ‘progeny’ poses an interesting question, especially given that there is overlap in their respective transmission ecologies, but differences in their infection host ranges and pathogenesis. We compared the in vivo kinetics of these three viruses in a common laboratory system and found no significant difference in growth kinetics. There was, however, a tendency of BATV to have smaller plaques than either BUNV or NRIV. Furthermore, we determined that all three viruses are stable in extracellular conditions and retain infectivity for a week in non-cellular media, which has public health and biosafety implications. The study of this understudied group of viruses addresses a need for basic characterization of viruses that have not yet reached epidemic transmission intensity, but that have the potential due to their infectivity to both human and animal hosts. These results lay the groundwork for future studies of these neglected viruses of potential public and One Health importance.

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“…placental membranes from infected ruminants, which contain large numbers of virus particles and blood. Furthermore, RVFV was observed or experimentally demonstrated to persist for long periods in different biotic or abiotic settings: a laboratory assistant was infected in a laboratory 4 months after the virus was handled in this laboratory; the virus may be isolated from carcase tissues such as spleen or liver between 36 and 72 h after death; and infected sheep plasma retained RVFV infectivity after 8 years of storage and shipment under a variety of refrigeration conditions . Consequently, veterinarians and laboratory, agricultural and slaughterhouse workers may be at risk.…”

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confidence: 99%

Relevance of Rift Valley fever to public health in the European Union

Chevalier

2013

Clinical Microbiology and Infection

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Rift Valley fever (RVF), a vector-borne zoonotic disease caused by a phlebovirus (family Bunyaviridae), is considered to be one of the most important viral zoonoses in Africa. It is also a potential bioterrorism agent. Transmitted by mosquitoes or by direct contact with viraemic products, RVF affects both livestock and humans, causing abortion storms in pregnant ruminants and sudden death in newborns. The disease provokes flu syndrome in most human cases, but also severe encephalitic or haemorrhagic forms and death. There is neither a treatment nor a vaccine for humans. The disease, historically confined to the African continent, recently spread to the Arabian Peninsula and Indian Ocean. Animal movements, legal or illegal, strongly contribute to viral spread, threatening the Mediterranean basin and Europe, where competent vectors are present. Given the unpredictability of virus introduction and uncertainties about RVF epidemiology, there is an urgent need to fill the scientific gaps by developing large regional research programmes, to build predictive models, and to implement early warning systems and surveillance designs adapted to northern African and European countries.

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Stability of Rift Valley fever virus at 4 C.

Cited by 7 publications

References 0 publications

Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention

Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention

Comparative characterization of the reassortant Orthobunyavirus Ngari with putative parental viruses, Bunyamwera and Batai: in vitro characterization and ex vivo stability

Relevance of Rift Valley fever to public health in the European Union

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