Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others

Oris, Charlotte; Bouvier, Damien; Pereira, Bruno; Saintonge, Adèle; Coelho, Anaïs; Sapin, Vincent

doi:10.1515/cclm-2022-1306

Clinical Chemistry and Laboratory Medicine (CCLM)

2023

DOI: 10.1515/cclm-2022-1306

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Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others

Charlotte Oris

Damien Bouvier

Bruno Pereira

et al.

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2024

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Cited by 2 publications

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The Clinical Impact of Sample Storage at −20 °C on Renin Reference Intervals and Aldosterone–Renin Ratio Calculations

Özcan,

Hillebrand,

den Elzen

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Cryoactivation was known to occur in whole blood and plasma samples when kept between +4 and -5°C leading to falsely high renin concentrations. In 2022 it has been clearly shown that cryoactivation can also occur in samples stored at -20°C.Based on these new findings here we discuss how this can influence the clinical diagnosis of patients. First, we show that storage of renin plasma samples can affect the renin measurements and thereby the aldosterone-to-renin ratio (ARR) calculation, which might explain the high intra-individual variability in ARR also recently demonstrated. Second, we discuss the existing studies on the establishment of renin reference intervals and noted the lack of attention given to this recently revealed preanalytical conditions. Our literature review of the reference intervals for renin suggest that cryoactivation might have influence the published data.

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The Clinical Impact of Sample Storage at −20 °C on Renin Reference Intervals and Aldosterone–Renin Ratio Calculations

Özcan,

Hillebrand,

den Elzen

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Reply to: Letter to the Editor From A.H. Jan Danser and Ingrid M. Garrelds: The Clinical Impact of Sample Storage at −20 °C on Renin Reference Intervals and Aldosterone-renin Ratio Calculations

Özcan,

Hillebrand,

den Elzen

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

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Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others

Cited by 2 publications

References 5 publications

The Clinical Impact of Sample Storage at −20 °C on Renin Reference Intervals and Aldosterone–Renin Ratio Calculations

The Clinical Impact of Sample Storage at −20 °C on Renin Reference Intervals and Aldosterone–Renin Ratio Calculations

Reply to: Letter to the Editor From A.H. Jan Danser and Ingrid M. Garrelds: The Clinical Impact of Sample Storage at −20 °C on Renin Reference Intervals and Aldosterone-renin Ratio Calculations

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