Stability of Organoleptic Agents in Pharmaceuticals and Cosmetics

Patil, Abhay; Bhide, Supriya; Bookwala, Mustafa; Soneta, Bhavik; Shankar, Vijaykumar; Almotairy, Ahmed; Almutairi, Mashan; Murthy, S. Narasimha

doi:10.1208/s12249-017-0866-2

Cited by 18 publications

(17 citation statements)

References 56 publications

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“…Vol.64: e21200429, 2021 www.scielo.br/babt The development of a new cosmetic product includes several steps between initial research and the final commercial product. The stability study is important to better understand the physical chemistry properties, to ensure organoleptic attributes consistency and to detect any instability [30,31]. Critical parameters that determine cosmetic stability are temperature, pH variation, and light exposure.…”

Section: Discussionmentioning

confidence: 99%

Stability and Sensory Evaluation of an Innovative Antiaging Formulation Based on Marine Ingredients

Fortunato

Gonçalves

Colusse

et al. 2021

Braz. arch. biol. technol.

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The high consumption of antiaging cosmetics represents an outstanding opportunity for the development of new processes and attractive products in the cosmetic industry. Stability studies and sensory analyses are critical steps in the development process and production chain. Here we present a potential antiaging cosmetic product with innovative sensory characteristics. Caviar extract antioxidant properties were firstly evaluated by the DPPH method since it is an important mechanism against skin aging. Ca-alginate beads containing 2% of caviar extract and 0.2% of black pigment were prepared to obtain spheres similar to caviar. The beads were incorporated in a gel phase (hydroxyethylcellulose 2.5%) containing 3% of dimethylaminoethanol. Stability was evaluated in different storage conditions (sunlight exposure, 5 ± 2 °C, 37 ± 2 °C and r.t.) through the parameters: appearance, color and odor, pH (6-7), density (0.98-1.14 g.mL -1 ), centrifugation and average size. After approval by the Committee for Ethics in Research (n° 3.503.061), 30 volunteers tested the new formulation and answered a questionnaire. At 2%, caviar extract was able to scavenge 10.9% ± 0.58 of DPPH radical. Formulations showed good stability after 90 days, even considering the average size (7.47 ± 0.41 -8.4 ± 0.65 mm 2 ). 90% of the sensory test participants reported that they would buy the new product. Therefore, the new product developed demonstrates a promising potential as an attractive cosmetic product. HIGHLIGHTS Marine environment has been an important source of cosmetic ingredients. Caviar extract (2%) has scavenged 10.9% ± 0.58 of DPPH radical. Ca-alginate beads has been obtained successfully. Formulation showed good stability and sensory acceptance.

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Section: Discussionmentioning

confidence: 99%

Stability and Sensory Evaluation of an Innovative Antiaging Formulation Based on Marine Ingredients

Fortunato

Gonçalves

Colusse

et al. 2021

Braz. arch. biol. technol.

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“…The selection of flavor depends on the type of drug to be incorporated. The acceptance of the oral disintegrating or dissolving formulation by an individual depends on the initial flavor which is perceived in the first few seconds after the dosage form has been consumed, and the after taste of the formulation, which lasts for at least about 10 min 56 . The use of flavors can be alone or in combination.…”

Section: Flavoring Agentsmentioning

confidence: 99%

Untitled

2020

IJPSR

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In the development of a new drug molecule, there are many problems with respect to the dissolution, absorption, and bioavailability. Thus, formulation scientists are majorly focusing on the development of the formulation, which will increase the efficacy of the existing drugs. Oral dispersible films are one of such a novel approach. In given review article, the advantages of oral dispersible films over other oral dosage form and especially over oral dispersible tablets and their applications are discussed. In further part the major advantages regarding first-pass metabolism, disable patients, fast onset, etc., are covered. Furthermore, the overview of all the ingredients used in the formulation of fast dissolving films with the evaluation of these films is discussed in the given review article. Solvent casting, semisolid casting, hot-melt extrusion, solid dispersion extrusion, rolling are the methods which are employed, along with the evaluation parameters like thickness, tear resistance, dryness test of the prepared films are also explored in the article. This review article gives a complete overview of oral dispersible films and their novel approach in the formulation. INTRODUCTION: Among the delivery routes, the oral route is the most acceptable with respect to patient compliance. Many pharmaceutical firms have directed their research activity in reformulating existing drugs into new dosage forms. One such relatively new dosage form is the oral film, a thin film that is prepared using hydrophilic polymers that rapidly dissolves on the tongue or buccal cavity. Developing formulations for children has been a challenging task. Amongst other factors, the palatability of formulations of pediatric oral medications is one of the most significant factors influencing compliance with therapeutic regimens 1, 2 .

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“…It is a precursor of the pyrimidine nucleotides and, in addition, is a key precursor for the synthesis of asparagine, methionine, lysine, threonine, and isoleucine (Garett and Grisham, 2010). It is known that these amino acids are participating in a variety of biochemical reactions, basic energy transfer and muscle activity and they are used for medical, cosmetic and industrial purposes (Zhu et al, 2011, Patil et al, 2018. It is also found that at higher concentrations aspartic acid affects the lifetime of the initial phase of CaCO3 crystallization, the amorphous calcium carbonate, through the inhibition of crystal nucleation and growth (Tobler et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical study of Aspartic acid

2019

Glas. hem. tehnol. Bosne Herceg.

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The aim of this research is to detect zwittterionic structure of the aspartic acid and confirm the experimental spectra with quantum chemical calculations. The experimental IR and Raman spectra of aspartic acid powder show no vibrational bands of OH and NH stretching in expected spectral region. We assume that zwitterionic structure of aspartic acid is responsible for lowering the frequencies of these vibrations. An extensive experimental and computational research supports this assumption. Our DFT calculation strongly suggests the need for the dielectric environment in order to stabilize the zwitterionic structure of a single molecule. The network of intermolecular hydrogen bonding between aspartic acid molecules provides this dielectric environment. The DFT quantum mechanical calculations corroborate this assumption by optimizing a four-member group of molecules, which also gives an explanation of broad IR spectrum lines.

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Stability of Organoleptic Agents in Pharmaceuticals and Cosmetics

Cited by 18 publications

References 56 publications

Stability and Sensory Evaluation of an Innovative Antiaging Formulation Based on Marine Ingredients

Stability and Sensory Evaluation of an Innovative Antiaging Formulation Based on Marine Ingredients

Untitled

Experimental and theoretical study of Aspartic acid

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