Stability of Morphine in Aqueous Solution III. Kinetics of Morphine Degradation in Aqueous Solution

Yeh, S.Y.; Lach, John L.

doi:10.1002/jps.2600500108

Cited by 62 publications

(26 citation statements)

References 5 publications

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“…It is known that the quality of glass affects the stability of morphine solutions [20] as non-silanised glass allows the release of caustic materials increasing the pH and thus the rate of degradation. In this experiment, all the glass containers were silanised with dimethylchlorosilane before use to minimise the effect of this phenomena.…”

Section: Resultsmentioning

confidence: 99%

Stability of morphine and buprenorphine in whole blood

Hadidi

Oliver

1998

International Journal of Legal Medicine

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Delays between time of sampling and time of toxicological analysis are common, therefore the length of time that postmortem blood can be stored at various temperatures (e.g. 4 degrees, 25 degrees, -20 degrees C) was evaluated for the effect on the stability of morphine and buprenorphine from day one up to one year. Solid phase extraction and GC-MS were used for the isolation and quantification of the drugs. Morphine and buprenorphine were found to be very stable for up to 6 months under these storage conditions, where at least 85% and 77% of morphine and buprenorphine respectively, were recovered. The study showed that a reasonable amount of the drugs (not less than 70%) was still detectable after one year of storage regardless of the temperature when blood samples were stored in silanized glass vessels.

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Section: Resultsmentioning

confidence: 99%

Stability of morphine and buprenorphine in whole blood

Hadidi

Oliver

1998

International Journal of Legal Medicine

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“…Differences in the activity of these analogs of acetylcholine have long been explained on the basis of molecular steric and electronic effects in the drug-receptor interaction (1,2). Spectral data concerned with conformational aspects of acetylcholine have also been studied and developed in recent attempts t o describe receptor site architecture (3)(4)(5)(6)(7).…”

Section: Resultsmentioning

confidence: 99%

“…3 A vacuum pump4 in conjunction with a fine metering valve5 permitted a complete and graduated evacuation of the flow system and analysis cell of the oxygen analyzer. A McLeod-type vacuum gauge6 was inserted into the manifold to monitor the efficiency of the evacuation process.…”

Section: Methodsmentioning

confidence: 99%

“…The adverse influence of atmospheric oxygen on both the physical and chemical stability of parenteral formulations and the numerous problems arising from the oxidative decomposition of drugs in the development of new products has been emphasized repeatedly in the past (1)(2)(3)(4)(5)(6). The inclusion of a suitable antioxidant system to inhibit the oxidative process and the replacement of air in the headspace of a product's container with an inert atmosphere are generally recognized as considerable aids in stabilizing an injectable formulation.…”

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confidence: 99%

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Sampling and Analysis of Oxygen in the Void Volume of Ampuls and Vials

Cullen¹,

Papariello²

1970

Journal of Pharmaceutical Sciences

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“…Morphine usually produces these metabolites when it comes in contact with atmospheric oxygen. Yeh and Lach (1961) first mentioned that degradation of morphine in solutions occurred in presence of atmospheric oxygen in the system. Vermeire and Remon (1999) concluded that degradation of morphine in aqueous solution is accelerated in the presence of atmospheric oxygen with the formation of mainly pseudomorphine, to a lesser extent morphine-n-oxide and probably apomorphine.…”

Section: Discussionmentioning

confidence: 99%