Conventional data sets for solving infectious disease equations are mostly in unidirectional form, and the efficiency of solving application is low, which leads to the increase of the average relative error of the equations. Therefore, the application of exponential tight differential operator in solving infectious disease equations is proposed to be analyzed. According to the current test requirements, the design of high-precision compact differential format is carried out first, and the multi-objective approach is adopted to improve the efficiency of the overall solution application, the multiobjective public data set is established, and the stability analysis of differential solution is realized, based on which the model design of solving infectious disease equations with exponential-type compact differential operator is constructed, and the modification of the boundedness judgment is adopted to realize the solution application. The results show that the average relative errors of the final equations for the selected four test cycles are well controlled below 1.3, which indicates that the designed method for solving the infectious disease equation is more targeted and effective, and has practical application value.