Stability of Hydrocortisone in Polyethylene Glycol Ointment Base

Degradation of Hydrocortisone in a Zinc Oxidelotion

“…The degradation of hydrocortisone in the formulations at 50°C could be evaluated by a first-order plot for over one half-life. Previous work on semi-solid formulations showed that the degradation of hydrocortisone in such formulations can be fitted to first-order kinetics (6,7). At room temperature approximately 10% of the hydrocortisone was lost in 2 weeks (Table 1).…”

“…Although a number of reports have appeared in the literature concerning the stability of hydrocortisone in aqueous solution with respect to kinetics and degradation products (1, 2, 3, 4), very little has been reported concerning the degradation of hydrocortisone in formulations. The effect of attapulgite, a potential formulation component, on the degradation of hydrocortisone in solution has been reported (5), and the stability of hydrocortisone in a number of semi-solid bases has been investigated (6,7). Decomposition was shown to follow first order kinetics, but no degradation products were identified.…”

Peroxide-Mediated Desulfurization of Phosphorothioate Oligonucleotides and Its Prevention

“…There are numerous reports in the literature describing oxidative degradation of PEG derivatives and degradation of active pharmaceutical ingredients caused by autoxidation and degradation products of polyether derivatives 21–28. To confirm the hypothesis that PS‐oligonucleotides are susceptible to hydroperoxide mediated desulfurization we exposed ASO‐ 1 to small model hydroperoxides.…”