Stability of Hematologic Parameters in Healthy Subjects: Intraindividual <i>versus</i> Interindividual Variation

Ross, Dennis W.; Ayscue, Lanier H.; Watson, Judith S.; Bentley, Stuart

doi:10.1093/ajcp/90.3.262

Cited by 70 publications

(43 citation statements)

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“…The degree of Hb variability that is present in patients with CKD, including those who are not receiving ESA, is greater than would be expected among patients without uremia (13)(14)(15). Variation of Hb in healthy individuals does occur (13)(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

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Hemoglobin Variability in Nondialysis Chronic Kidney Disease

Boudville¹,

Djurdjev²,

Macdougall³

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background and objectives: Anemia and hemoglobin (Hb) variability are associated with mortality in hemodialysis patients who are on erythropoiesis-stimulating agents (ESA). Our aim was to describe the degree of Hb variability present in nondialysis patients with chronic kidney disease (CKD), including those who were not receiving ESA, and to investigate the association between Hb variability and mortality.Design, setting, participants, & measurements: Hb variability was determined using 6 mo of "baseline" data between January 1, 2003, and October 31, 2005. A variety of definitions for Hb variability were examined to ensure consistency and robustness.Results: A total of 6165 patients from 22 centers in seven countries were followed for a mean of 34.0 ؎ 15.8 mo; 49% were prescribed an ESA. There was increased Hb variability with ESA use; the residual SD of Hb was 4.9 ؎ 4.4 g/L in patients who were not receiving an ESA, compared with 6.8 ؎ 4.8 g/L. Hb variability was associated with a small but significantly increased risk for death per g/L residual SD, irrespective of ESA use. Multivariate linear regression model explained only 11% of the total variance of Hb variability.Conclusions: Hb variability is increased in patients who have CKD and are receiving ESA and is associated with an increased risk for death (even in those who are not receiving ESAs). This analysis cannot determine whether Hb variability causally affects mortality. Thus, the concept of targeting Hb variability with specific agents needs to be examined within the context of factors that affect both Hb variability and mortality.

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Section: Discussionmentioning

confidence: 99%

“…Variation of Hb in healthy individuals does occur (13)(14)(15)(16). It is both diurnal and fluctuating over periods of time up to 1 yr (14,15).…”

Section: Discussionmentioning

confidence: 99%

Hemoglobin Variability in Nondialysis Chronic Kidney Disease

Boudville¹,

Djurdjev²,

Macdougall³

et al. 2009

Clinical Journal of the American Society of Nephrology

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“…It was observed that almost all the cases had Platelet count within the normal range 150,000 to 400,000 per cubic millimetre. [7] Preoperatively the Mean of Platelet count was 261x103 with S.D of 49 and postoperatively 263x103 with S.D of 65. WBC count was also observed to lie in the normal range 4500 to 11000 per cubic millimeter.…”

Section: Resultsmentioning

confidence: 90%

Effect of Septoplasty on Mean Platelet Volume in Patients of Deviated Nasal Septum

Rahman¹,

Tasleem²,

Arif³

2016

AIMDR

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Background: Mean platelet volume corresponds to average size of platelets and studies proved that large platelets are enzymatically and metabolically more active and have prothrombotic potential. Chronic upper airway like marked nasal septal deviation leads to higher Mean platelet volume and vice versa septoplasty operation lowers the volume of the platelets over a period of time and hence reduces other associated comorbidities. Objectives: This study was done with an aim to analyze the effect of Septoplasty on Mean Platelet Volume Levels in patients with Marked Nasal Septal Deviation. Methods: A prospective study was done in a total of 50 patients who were selected from ENT OPD and ENT Ward of Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh after proper history and examination. Results: Data obtained from preoperative and postoperative blood investigation were analysed using paired t-test and it was statistically proved that after Septoplasty, Mean Platelet Volume was significantly lowered in patients who had Marked Nasal Septal Deviation. Conclusion: Septoplasty plays an important role in reducing the MPV value in cases with Marked nasal septal deviation and thus other comorbid conditions can be prevented by doing septoplasty in these patients.

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“…Individuals' hematologic parameters are fairly stable over time, especially the PLT count [37][38][39][40]. Dot et al serially assessed several common hematological parameters once per month for a year in 39 healthy volunteers and found that the over-time variation of those parameters was very low.…”

Section: Discussionmentioning

confidence: 99%

Association of single nucleotide polymorphisms in the thrombopoietin‐receptor gene, but not the thrombopoietin gene, with differences in platelet count

et al. 2004

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Little is known about the mechanisms explaining the wide variation in platelet counts (PLT) and other hematologic parameters in humans. We previously showed that the sexbased difference in hematocrit was associated with nucleotide variation in the erythropoietin receptor gene (EPOR). We sought to identify new polymorphisms of the human thrombopoietin (TPO) and thrombopoietin receptor (TPOR) genes to determine any associations with blood PLT counts. We screened TPO and TPOR for polymorphisms using single-strand conformation polymorphism (SSCP) and DNA sequencing. Association of polymorphisms was studied in 304 normal subjects with low or high PLT counts. Distribution of allelic frequency was analyzed by the Chi-square statistic. Single nucleotide polymorphisms (SNPs) with two alleles were found in TPO and TPOR. The TPO SNP was a G to A transition at nucleotide 5753, and the TPOR SNP was a C to A transversion at position 550 in the 5 0 -promoter area. The allelic frequencies were 0.54 for G and 0.46 for A of TPO, and 0.62 for C and 0.38 for A of TPOR in a Caucasian population. The frequency of the TPOR allele ''C'' was significantly higher in subjects with high PLT count (>258 k/mm ). In contrast, the frequency of the TPO alleles was not related to blood PLT counts. An association of TPO and TPOR allele distribution to red and white blood cell parameters was seen. These new SNPs found for the human TPO and TPOR genes help explain variations in blood PLT counts and may be useful in patient studies related to the roles of TPO and/or TPOR in disease. Am.

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Stability of Hematologic Parameters in Healthy Subjects: Intraindividual versus Interindividual Variation

Cited by 70 publications

References 0 publications

Hemoglobin Variability in Nondialysis Chronic Kidney Disease

Hemoglobin Variability in Nondialysis Chronic Kidney Disease

Effect of Septoplasty on Mean Platelet Volume in Patients of Deviated Nasal Septum

Association of single nucleotide polymorphisms in the thrombopoietin‐receptor gene, but not the thrombopoietin gene, with differences in platelet count

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