Stability of emulsions stabilised by two physiological surfactants: l-α-phosphatidylcholine and sodium taurocholate

Fillery-Travis, Annette; Foster, L.H.; Robins, Margaret M.

doi:10.1016/0301-4622(94)00136-8

Cited by 44 publications

(30 citation statements)

References 12 publications

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“…A further increase in the concentration of NaDC did not provide additional benefits in terms of polydispersity These results are in accordance with previous studies which demonstrated that an increase in the concentration of anionic bile salt results in increased zeta potentials until a maximum value is reached (22,23). The increase in zeta potential indicates significant adsorption of the bile salt at the emulsion interface thereby providing enhanced stability through electrostatic repulsion.…”

Section: Concentration Of Emulsion Stabilizerssupporting

confidence: 92%

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Influence of Formulation and Processing Variables on Properties of Itraconazole Nanoparticles Made by Advanced Evaporative Precipitation into Aqueous Solution

et al. 2012

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Abstract. Nanoparticles, of the poorly water-soluble drug, itraconazole (ITZ), were produced by the Advanced Evaporative Precipitation into Aqueous Solution process (Advanced EPAS). This process combines emulsion templating and EPAS processing to provide improved control over the size distribution of precipitated particles. Specifically, oil-in-water emulsions containing the drug and suitable stabilizers are sprayed into a heated aqueous solution to induce precipitation of the drug in form of nanoparticles. The influence of processing parameters (temperature and volume of the heated aqueous solution; type of nozzle) and formulation aspects (stabilizer concentrations; total solid concentrations) on the size of suspended ITZ particles, as determined by laser diffraction, was investigated. Furthermore, freeze-dried ITZ nanoparticles were evaluated regarding their morphology, crystallinity, redispersibility, and dissolution behavior. Results indicate that a robust precipitation process was developed such that size distribution of dispersed nanoparticles was shown to be largely independent across the different processing and formulation parameters. Freeze-drying of colloidal dispersions resulted in micron-sized agglomerates composed of spherical, sub-300-nm particles characterized by reduced crystallinity and high ITZ potencies of up to 94% (w/w). The use of sucrose prevented particle agglomeration and resulted in powders that were readily reconstituted and reached high and sustained supersaturation levels upon dissolution in aqueous media.

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Section: Concentration Of Emulsion Stabilizerssupporting

confidence: 92%

“…The combined use of lecithin and bile salts has been previously shown to significantly enhance emulsion stability (22,23). Additive adsorption of both stabilizers leads to a mixed lipid emulsion droplet interface which results in higher stability than emulsion systems stabilized by either surfactant alone.…”

Section: Concentration Of Emulsion Stabilizersmentioning

confidence: 99%

Influence of Formulation and Processing Variables on Properties of Itraconazole Nanoparticles Made by Advanced Evaporative Precipitation into Aqueous Solution

et al. 2012

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“…It has been proposed that the adsorption of pancreatic lipase is facilitated by the presence of bile acids that are released from the gall bladder or directly from the liver, and by the presence of co-lipase that is released from the pancreas (Mun et al, 2006). Therefore, the nature of the interfacial layer surrounding the lipid droplets is expected to play an important role in determining the rate and extent of lipid hydrolysis (Fillery-Travis et al, 1995). Additional surfaceactive substances may be produced during the hydrolysis of tri-, di-and mono-glycerides, as well as free fatty acids (FFA) (Bauer et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Gastrointestinal Digestibility of Soybean Oil-in-Water Emulsion Droplets Stabilized by Polyglycerol Esters of Fatty Acid

Wang

Neves

Yin

et al. 2012

FSTR

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The objective of this work was to investigate the influence of polyglycerol esters of monolaurate on the properties of soybean oil-in-water submicron emulsions, with dispersed phase of 1 wt% to 10 wt% soybean oil, passing through an in vitro digestion model. The addition of pancreatic lipase to the emulsions, either alone or in combination with bile extract, led to increases in mean droplet diameter and ζ-potential absolute values. The stability of the submicron emulsions against droplet flocculation and coalescence during gastrointestinal passage was strongly dependent on emulsifier type. The total amount of free fatty acids by the end of the digestion period was fairly similar, regardless of the type emulsifier used. When the dispersed phase concentrations decreased from 10 wt% to 1 wt%, the conversion to free fatty acids ranged from 36.2% to 91.5%.

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“…pholipids effects the properties of many emulsion systems, influencing emulsion stability [6], droplet deformation and suspension rheology [7]. As the physicochemical properties of monolayers are similar to those of bilayers, monolayers and bilayers of phospholipids mixed with cholesterol have been studied extensively both in the context of cell physiology [8,9] and artificial bilayer systems like liposomes [10].…”

Section: Introductionmentioning

confidence: 99%

Surface rheology of monolayers of phospholipids and cholesterol measured with axisymmetric drop shape analysis

Vrânceanu

Winkler

Nirschl

et al. 2007

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Surface rheology of monolayers of a saturated phospholipid (dipalmitoylphosphatidylcholine, DPPC), an unsaturated phospholipid (dioleoylphosphatidylcholine, DOPC) and cholesterol is studied with axisymmetric drop shape analysis at the argon/water interface. Measurement techniques for lipids are described in detail. Profile analysis tensiometry (PAT) is used to determine the film pressure Π, surface elasticity and surface dilational viscosity of monolayers upon sinusoidal oscillations of the drop surface for various amplitudes a and frequencies f to assess their dependence on these dynamic parameters. It is shown that surface dilational viscosity strongly depends on the frequency and decreases by a factor 2-5 with increasing f in the considered range. Dilational viscosity is higher the more the monolayer approaches a relaxed state. Thus, the molecular interactions are stronger in the relaxed than in the stressed state. Surface elasticity is much less dependent on dynamic conditions. For DPPC a minimum of the dynamic surface elasticity is found for f = 12.5 mHz (at Π = 17.5 mN m −1 ) which coincides well with the relaxation frequencies measured in stress relaxation experiments. The dynamic surface elasticity of DPPC exhibits a plateau in the range 13.5 mN m −1 ≤ Π ≤ 27 mN m −1 in good coincidence with the phase boundaries of the coexistence region of micron-sized liquid crystalline domains surrounded by a fluid monolayer phase. In equilibrium measurements (Π/A-isotherms) a plateau of the film pressure is seen at the lower bound and a break at the upper bound of the coexistence region. Film pressure/area isotherms produced by PAT and a Langmuir film balance closely coincide as is shown in a comparison to literature values. However, the surface elasticities measured dynamically with oscillating surfaces widely deviate from those derived from isotherms in the case of DPPC and cholesterol, whereas for DOPC very good agreement can be found.

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Stability of emulsions stabilised by two physiological surfactants: l-α-phosphatidylcholine and sodium taurocholate

Cited by 44 publications

References 12 publications

Influence of Formulation and Processing Variables on Properties of Itraconazole Nanoparticles Made by Advanced Evaporative Precipitation into Aqueous Solution

Influence of Formulation and Processing Variables on Properties of Itraconazole Nanoparticles Made by Advanced Evaporative Precipitation into Aqueous Solution

In Vitro Gastrointestinal Digestibility of Soybean Oil-in-Water Emulsion Droplets Stabilized by Polyglycerol Esters of Fatty Acid

Surface rheology of monolayers of phospholipids and cholesterol measured with axisymmetric drop shape analysis

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