Stability of dental implants after irradiation with an 830-nm low-level laser: a double-blind randomized clinical study

Effect of Three Different Protocols of Low-Level Laser Therapy on Thyroid Hormone Production After Dental Implant Placement in an Experimental Rabbit Model

“…These findings differed from those reported by Lerma et al 40 after heliumneon (HeNe) LLLT in the thyroid gland of Wistar rats, who found no difference in serum levels of thyroid hormones. Likewise, Fronza et al 38 found no significant differences in serum T3 and T4 levels after 6 J/cm 2 GaAlAs LLLT applied to a rabbit fresh incisor socket experimental model. However, our findings do corroborate those of Azevedo et al, 25 who administered three doses of 4 J/cm 2 GaAlAs 780 nm LLLT directly over the thyroid gland in mice.…”

“…The type of comparison that we presented here would not have been possible with a split-mouth design 2 or a subjectas-own-control design.…”

“…In all experimental groups, irradiation was performed every 48 h, for a total of seven sessions over 13 days, with total cumulative doses of 35 J/cm 2 for group E-5, 70 J/cm 2 for group E-10, and 140 J/cm 2 for group E-20 (Table 1). Using methods similar to those of Mebis et al 37 and Fronza et al, 38 levels of T3, T4, and calcium were measured in all animals at four points in time: before dental extraction/ implant placement; immediately after surgery; after the first LLLT session; and after the last LLLT session.…”

“…Previous studies have evaluated the irradiation of extraction sockets, 3 modulation of skin wound healing, [4][5][6] regeneration of nervous tissue, 5 enhancement of peri-implant tissue repair after implant placement, 2,[7][8][9][10][11][12][13][14][15][16] and modulation of postoperative pain. 2,7,[17][18][19][20][21][22][23][24] Other in vivo and in vitro studies have reported the positive effects of LLLT on the repair process in animal models and tissue cultures.…”

“…Previous studies have evaluated the irradiation of extraction sockets, 3 modulation of skin wound healing, [4][5][6] regeneration of nervous tissue, 5 enhancement of peri-implant tissue repair after implant placement, 2,[7][8][9][10][11][12][13][14][15][16] and modulation of postoperative pain. 2,7,[17][18][19][20][21][22][23][24] Other in vivo and in vitro studies have reported the positive effects of LLLT on the repair process in animal models and tissue cultures. 4,22,25 However, there are large variations in laser doses, [7][8][9][10][11][12][13][14][15]26 even though dose is considered an important parameter in laser therapy, 27 especially when some specific biomodulatory effects are expected.…”