Stability of curcumin in different solvent and solution media: UV–visible and steady-state fluorescence spectral study

Mondal, Satyajit; Ghosh, Soumen; Moulik, Satya P.

doi:10.1016/j.jphotobiol.2016.03.004

Cited by 150 publications

(94 citation statements)

References 30 publications

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“…We performed a UV-Vis spectrum analysis of our curcuminoid preparation and saw an absorption maximum at 427 nm in ethanol ( Figure 3A), which was in agreement with values reported previously [28,29]. Further analysis with fluorescence spectroscopy indicated an emission maximum between 532-538 nm ( Figure 3B).…”

Section: Isolation Of Curcuminoids From Turmeric Powder and Charactersupporting

confidence: 87%

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway

Castaño

Parween

Pandey

2019

Preprint

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Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have potent wound healing, anti-inflammatory, and anti-carcinogenic activities. While curcuminoids have been studied for many years, not much is known about their effects on steroid metabolism. Since many anti-cancer drugs target enzymes from the steroidogenic pathway, we tested the effect of curcuminoids on cytochrome P450 CYP17A1, CYP21A2, and CYP19A1 enzyme activities. When using 10 µg/ml of curcuminoids, both the 17α-hydroxylase as well as 17,20 lyase activities of CYP17A1 were reduced significantly. On the other hand, only a mild reduction in CYP21A2 activity was observed. Furthermore, CYP19A1 activity was also reduced up to ~20% of control when using 1-100 µg/ml of curcuminoids in a dose-dependent manner. Molecular docking studies confirmed that curcumin could dock into the active sites of CYP17A1, CYP19A1 as well as CYP21A2. In CYP17A1 and CYP19A1, curcumin docked within 2.5 Å of central heme while in CYP21A2 the distance from heme was 3.4 Å, which is still in the same range or lower than distances of bound steroid substrates. These studies suggest that curcuminoids may cause inhibition of steroid metabolism, especially at higher dosages. Also, the recent popularity of turmeric powder as a dilatory supplement needs further evaluation for the effect of curcuminoids on steroid metabolism. Molecular structure of curcuminoids could be modified to generate better lead compounds with inhibitory effects on CYP17A1 and CYP19A1 for potential drugs against prostate cancer and breast cancer.

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Section: Isolation Of Curcuminoids From Turmeric Powder and Charactersupporting

confidence: 87%

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway

Castaño

Parween

Pandey

2019

Preprint

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“…On the other hand, in the 1,250 cm −1 , the co‐shift of OH group (around 1,250 cm −1 to lower wavenumber), does not show a characteristic of the enol group (Fan et al, ; Li et al, ). In accordance with absorbance spectra of curcumin, the peak maximum around 430 nm in different polar solvent and surfactant solutions is the response of the enol group (Mondal, Ghosh, & Moulik, ). Figure shows the absorbance spectra of curcumin solutions, in the region of 430 nm (CurTween and CurEthanol solutions) and 420 nm (CurWine solution).…”

Section: Resultsmentioning

confidence: 74%

Vacuum curcumin infusion in cooked oysters (Crassostrea gigas) to increase their shelf life

Koop

Cargnin

Fidler

et al. 2019

J Food Process Engineering

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Curcumin solutions were infused into cooked oysters by vacuum and the best solution was chosen to inhibit growth of total mesophilic and total psychrophilic bacteria in oysters during storage. Shelled cooked oysters were immersed in three different curcumin solutions (130 μg/mL): tween, ethanol (3.5% of alcohol), and white wine (3.5% of alcohol). Oysters immersed in curcumin solution were subjected to vacuum‐infusion at 200 mbar for 20 min. Raman spectra showed that curcumin was present in all solutions. However, the oysters infused with curcumin white wine solution showed best results. After that, oysters were immersed in curcumin white wine solution and vacuum‐infused under 200 mbar for 1, 3, and 20 min, packaged and stored at 4°C for 14 days. 27.30 μg of curcumin/g of oyster infused into oysters for 20 min was the most effective concentration against mesophilic and psychrophilic bacteria during storage. The physicochemical characteristics of oysters were preserved. Practical Application Curcumin is a bioactive compound with antimicrobial and antioxidant properties and was used in this research. Positive antimicrobial effect was observed through increased shelf life of cooked oysters, opening up possibilities for industrial purposes. In addition, the vacuum infusion can be an alternative for incorporation of natural additives in food products as a substitute with chemical additives.

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“…The varied presence of the two forms of curcumin in water-ethanol medium herein presented from visible spectra has been a new addition to the understanding of the solution behaviour of curcumin. In pure water 30.34 % enol and 69.66 % keto forms were found which rapidly changed into 85.5 % enol and 14.5 % keto forms in 40 % ethanol [72]. The absorption maxima around 425 nm region is due to the enol group and that at 360 nm is due to the keto group.…”

Section: Resultsmentioning

confidence: 93%

“…Curcumin in aqueous solutions degrades rapidly and the order of reaction increases with increase in pH. The major degradation products are vanillin, acetone, feruloylmethane and ferulic acid [72,76,77]. Fig.…”

Section: Precision and Accuracymentioning

confidence: 99%

Development and Validation of High Performance Liquid Chromatography Method for Simultaneous Estimation of Curcuminoids from Rhizome Extracts

Begum¹,

Bolla²,

Sridevi³

2017

Asian J. Chem.

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Stability of curcumin in different solvent and solution media: UV–visible and steady-state fluorescence spectral study

Cited by 150 publications

References 30 publications

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathway

Vacuum curcumin infusion in cooked oysters (Crassostrea gigas) to increase their shelf life

Development and Validation of High Performance Liquid Chromatography Method for Simultaneous Estimation of Curcuminoids from Rhizome Extracts

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