Stability of cisplatin in ethylene vinylacetate portable infusion-pump reservoirs

Abstract

The stability of cisplatin in admixture stored in portable pump reservoirs was investigated. Admixtures containing 0.9 or 0.5 mg/ml cisplatin in 0.9% sodium chloride injection were placed in 80-ml ethylene vinylacetate (EVA) drug reservoirs protected from light and 1-ml quantities were withdrawn immediately after preparation and after storage for 1, 2, 3, 4, 7, 14, 28 days at +22 or +35 degrees C. Three samples for each condition from each admixture were tested for drug concentration using a stability-indicating high-performance liquid chromatographic method. No colour change or precipitation was observed, and pH values were stable for the duration of the study. Loss of water through the reservoirs was substantial only when stored at +35 degrees C for 28 days. Cisplatin is stable in the infusion fluid used for 28 days under all the storage conditions considered.

The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%

“…Rochard et al . proved the stability of cisplatin in concentrations of 0.5 and 0.9 mg/ml, which was placed in ambulatory infusion pumps made from ethylene-vinyl acetate and stored at the temperature of 22°C and 35°C for 28 days [14]. Swell [7] points to the stability of Teva cisplatin solution diluted to the concentrations of 0.1 and 0.4 mg/ml with a 0.9% NaCl solution, placed in PVC bags and stored at the temperature of 25°C without access to light for 28 days.…”

Long-term stability of vancomycin hydrochloride in intravenous infusions

“…Immediately after preparation and at 1,2,3,4,7,9,11,14,16,18,22, 25, 28, 30, 37, 51 and 58 days, 2ml of solution were withdrawn from each bag using 5 ml polypropylene plastic syringes (Terumo, Haasrode, Belgium) and placed in glass containers. The admixtures were visually inspected and the pH measured.…”

“…It is usually given as an admixture in 5% dextrose or 0.9% sodium chloride injection solutions (2). Advance batch preparation of intravenous solutions is efficient and is Correspondence: Dr L. M. Galanti, Laboratory, University Hospital of Mont-Godinne, Belgium. increasingly being used by hospital pharmacists in several countries (3)(4)(5)(6)(7)(8)(9). Centralized preparation of antibiotics requires that their stability is known (10).…”

Evaluation of Cisplatin Efficacy on HepG2 and E. coli Cells under Acidic Conditions

“…Results of the study indicated the stability of the drug for 14 days in all storage containers: polypropylene bags (100.1 ± 0.5%), glass bottles (99.7 ± 0.3%), polyethylene bags (98.9 ± 1.0%) and PVC bags (104.6 ± 1.0%). Rochard et al, (1992) prepared the concentration of 0.5 and 0.9 mg/ml of Cispt and located into ambulatory infusion pumps constructed from ethylene-vinyl acetate at 22°C and 35°C for 28 days. The results of the study confirmed the stability of Cispt in the both concentrations.…”