Stability of Body Weight in Type 2 Diabetes

Abstract

OBJECTIVE -There is a concern that an "epidemic of obesity" is occurring in Western societies. One consequence of obesity is that type 2 diabetes may develop. Presumably, a great increase in body weight would continue in people with diabetes and may be accelerated due to pharmacological treatment. In this retrospective study, we tested the hypothesis that the weight gain in a diabetic population is greater than that in the general population.RESEARCH DESIGN AND METHODS -Data were obtained from the records of 205 adult men who have attended a diabetes clinic for Ն5 years. Their weight and glycohemoglobin at the last visit were compared with the initial visit data. The subjects were categorized according to treatment modalities. The mean follow-up was 9.4 years (range 5-23).RESULTS -For the group as a whole, the mean increase in body weight was 0.23 Ϯ 0.2 kg/year. BMI or initial age had little effect on the rate of weight gain. Treatment regimen used did have an effect on weight change. In subjects treated with insulin, with or without oral agents, body weight increased at a rate of 0.44 Ϯ 0.1 kg/year. In subjects treated with metformin or metformin and a sulfonylurea, there was a mean loss in weight, i.e., Ϫ0.24 Ϯ 0.09 kg/year, and with sulfonylureas alone weight increased by 0.42 Ϯ 0.2 kg/year. CONCLUSIONS -The men treated with insulin alone or insulin combined with oral agents gained weight at a rate comparable with that reported for the general population, i.e., the weight gain was not extraordinary. Metformin treatment resulted in a modest loss of weight. Diabetes Care 29:493-497, 2006

BMI Change Patterns and Disability Development of Middle-aged Adults with Diabetes: A Dual Trajectory Modeling Approach

“…In addition, we found that higher proportion of insulin users in this group than in other weight trajectory groups, supporting previous research linking insulin use and weight accumulation. 3,20 Since obesity and weight gain are risk factors for diabetes prognosis, more focus should be placed on constructing coping strategies to counteract insulin-related weight gain, especially in obese adults with diabetes.…”

“…Research in clinical and community settings has examined general weight change patterns in adults living with diabetes over time, yielding inconsistent findings [2][3][4][5][6][7] and suggesting that the longitudinal course of body weight in middle-aged and older adults with diabetes exhibits not only intra-individual but also inter-individual variation.…”

Present status of sulfonylurea treatment for type 2 diabetes in Japan: Second report of a cross-sectional survey of 15,652 patients

“…This suggests that, for Japanese T2DM patients, the addition of either biguanide or TZD to sulfonylurea does not necessarily improve glycemic control. It has been reported that the metformin monotherapy reduced body weight and reversed the weight gain by sulfonylurea in combination with sulfonylurea, while BMI of the patients treated with sulfonylurea alone compared with sulfonylurea plus metformin was variable [26,27]. Our study was not longitudinal and could not detect the changes in body weight, therefore, we could not discuss the desirable effect of metformin on BMI.…”

Stability of Body Weight in Type 2 Diabetes

“…I n a recent volume in this journal, Chaudhry et al (1) reported their findings of weight change in 205 men with diabetes. They conclude that over the course of at least 5 years, modest weight gain is the norm in men with diabetes.…”