Stability of biphasic vesicles with membrane embedded proteins

Ni, Dong; Shi, Hui‐Ji; Yin, Yajun; Niu, Li‐Sha

doi:10.1016/j.jbiomech.2006.06.015

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…The composite of an elastic porous solid and the liquid that fills the pores plays an important role in the mechanical behavior of these tissues (Mak, 1986; Mow et al, 1993). Based on the biphasic theory (Mow et al, 1980), many mechanical models have been proposed to study the biomechanical properties of various tissue, such as the lumbar disc (Williams et al, 2007), stability of vesicles (Ni et al, 2007), the deformation of chondrocytes (Wu et al, 1999; Guilak and Mow, 2000; Wu and Herzog, 2006), the viscoelastic properties of articular cartilage (Ateshian et al, 1994; Ferguson et al, 2000; DiSilvestro and Suh, 2001; García and Cortés, 2006; Suh and Bai, 1998), the temporomandibular joint disc (Donzelli et al, 2004), the tendon in uniaxial tension (Yin and Elliott, 2004), cortical bone permeability (Malachanne et al, 2008), and so on. These models, based on a biphasic poroelastic theory, have successfully explained the experimental behavior and microstructure of these tissues.…”

Section: Introductionmentioning

confidence: 99%

A fluid-saturated poroelastic model of the vocal folds with hydrated tissue

Tao

Jiang

2009

Journal of Biomechanics

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The purpose of this study is to develop a continuous model to describe the vibration of the vocal fold with hydrated tissue. This model is unique because it is based on the fluid-saturated porous solid theory. Therefore, this new model can be used to study some vocal fold characteristics that would be difficult to predict using previous models. Numerical simulations show that this model can generate self-oscillation and that its phonation threshold pressure (PTP) is 0.555 kPa. The basic outputs of this model, including fundamental frequency, maximum lateral displacement, surface dynamics, and empirical eigenfunctions, agree with previous models and experimental studies, which validates this new model. The ability to simulate the flow of liquid through the tissue is one of the important advantages of this new model. It was found that the liquid in the vocal fold tissue could be accumulated at the anterior–posterior midpoint during phonation, which could cause a pressure increase in the liquid. The liquid pressure increased from 0.033 to 0.150 kPa when the subglottal pressure increased from 0.555 kPa (PTP) to 0.7 kPa. It was believed that the liquid dynamics in the tissue during phonation could be related to the development of some vocal diseases, such as vocal nodules, edema, and so on. Therefore, we expect that this model might not only provide a more appropriate description of the vocal fold vibration, but that it could also have clinical value in investigating certain vocal fold diseases.

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Section: Introductionmentioning

confidence: 99%

A fluid-saturated poroelastic model of the vocal folds with hydrated tissue

Tao

Jiang

2009

Journal of Biomechanics

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Mechanical Stability of Micropipet-Aspirated Giant Vesicles with Fluid Phase Coexistence

2008

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Micropipet aspiration of phase-separated lipid bilayer vesicles can elucidate physicochemical aspects of membrane fluid phase coexistence. Recently, we investigated the composition dependence of line tension at the boundary between liquid-ordered and liquid-disordered phases of giant unilamellar vesicles obtained from ternary lipid mixtures using this approach. Here we examine mechanical equilibria and stability of dumbbell-shaped vesicles deformed by line tension. We present a relationship between the pipet aspiration pressure and the aspiration length in vesicles with two coexisting phases. Using a strikingly simple mechanical model for the free energy of the vesicle, we predict a relation that is in almost quantitative agreement with experiment. The model considers the vesicle free energy to be proportional to line tension and assumes that the vesicle volume, domain area fraction, and total area are conserved during aspiration. We also examine a mechanical instability encountered when releasing a vesicle from the pipet. We find that this releasing instability is observed within the framework of our model that predicts a change of the compressibility of a pipet-aspirated membrane cylinder from positive (i.e., stable) to negative (unstable) values, at the experimental instability. The model furthermore includes an aspiration instability that has also previously been experimentally described. Our method of studying micropipet-induced shape transitions in giant vesicles with fluid domains could be useful for investigating vesicle shape transitions modulated by bending stiffness and line tension.

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Effects of poroelastic coefficients on normal vibration modes in vocal-fold tissues

Tao

Liu

2011

The Journal of the Acoustical Society of America

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The vocal-fold tissue is treated as a transversally isotropic fluid-saturated porous material. Effects of poroelastic coefficients on eigenfrequencies and eigenmodes of the vocal-fold vibration are investigated using the Ritz method. The study demonstrates that the often-used elastic model is only a particular case of the poroelastic model with an infinite fluid-solid mass coupling parameter. The elastic model may be considered appropriate for the vocal-fold tissue when the absolute value of the fluid-solid mass coupling parameter is larger than 10(5) kg/m(3). Otherwise, the poroelastic model may be more accurate. The degree of compressibility of the vocal tissue can also been described by the poroelastic coefficients. Finally, it is revealed that the liquid and solid components in a poroelastic model could have different modal shapes when the coupling between them is weak. The mode decoupling could cause desynchronization and irregular vibration of the folds.

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Stability of biphasic vesicles with membrane embedded proteins

Cited by 4 publications

References 32 publications

A fluid-saturated poroelastic model of the vocal folds with hydrated tissue

A fluid-saturated poroelastic model of the vocal folds with hydrated tissue

Mechanical Stability of Micropipet-Aspirated Giant Vesicles with Fluid Phase Coexistence

Effects of poroelastic coefficients on normal vibration modes in vocal-fold tissues

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