2001
DOI: 10.1016/s0969-8043(00)00313-4
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Stability of biodegradable radioactive rhenium (Re-186 and Re-188) microspheres after neutron-activation

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Cited by 40 publications
(19 citation statements)
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“…Elution was performed with THF and the flow rate was 1 mL/min. The mesopore column was used since low molecular weights of PLLA were expected due to the neutron irradiation 15,20 and THF is a suitable solvent for (neutron-irradiated) PLLA. 20 The columns were calibrated using polystyrene standards of known molecular weights (Shodex and Tosoh, Polymer Laboratories).…”
Section: Gel Permeation Chromatography (Gpc)mentioning
confidence: 99%
“…Elution was performed with THF and the flow rate was 1 mL/min. The mesopore column was used since low molecular weights of PLLA were expected due to the neutron irradiation 15,20 and THF is a suitable solvent for (neutron-irradiated) PLLA. 20 The columns were calibrated using polystyrene standards of known molecular weights (Shodex and Tosoh, Polymer Laboratories).…”
Section: Gel Permeation Chromatography (Gpc)mentioning
confidence: 99%
“…In addition, tumor cells can be continuously exposed throughout the cell cycle to the radiation of radionuclides carried by the microspheres or particles. In recent years, radiolabeled microspheres and particles have been used in clinical settings or animal studies, including 90 Y glass or resin microspheres [2,3], 32 P glass microspheres or colloids [4,5], 166 Ho-loaded glass microparticles [6], 186/188 Re glass microspheres [7] and various biodegradable microspheres, such as 166 Ho poly(L-lactic acid) microspheres(PLLA-MS) [8], and these microspheres and particles showed excellent anti-tumoral effects and a good level of safety after intraarterial or intratumoral injections. There are two forms of commercially available 90 Y microspheres — TheraSphere ® and SIR-Spheres ® — which were approved by the FDA, respectively, in 2000 for use in radiation treatment for inoperable hepatocellular carcinoma and in 2002 for the treatment of colorectal cancer metastasized to the liver [9].…”
Section: Introductionmentioning
confidence: 99%
“…The modified particles were radiolabeled with rhenium-188 for biomagnetically targeted therapy. Previously, Häfeli et al [90,91,136] demonstrated this technique in both animal and cell culture studies using yttrium-90 and rhenium-188.…”
Section: Active Targeting Radioactive Nanoparticlesmentioning
confidence: 99%
“…The specific activity was 0.1 mCi 188 ReO 4 − per 5 mg of NPs; the best labeling condition was optimized in a volume of 100 L for 50 min at 37 • C. The labeling efficiency was about 90% and the stability of the product in serum albumin was 80% after 10 h. In vitro results showed that 188 Re-labeled particles killed SMMC-7721 cells effectively [136].…”
Section: Active Targeting Radioactive Nanoparticlesmentioning
confidence: 99%