Stability of biodegradable radioactive rhenium (Re-186 and Re-188) microspheres after neutron-activation

Häfeli, Urs O.; Roberts, William K.; Pauer, Gayle J.; Kraeft, Stine-Kathrein; Macklis, Roger M.

doi:10.1016/s0969-8043(00)00313-4

Cited by 40 publications

(19 citation statements)

References 29 publications

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“…Elution was performed with THF and the flow rate was 1 mL/min. The mesopore column was used since low molecular weights of PLLA were expected due to the neutron irradiation 15,20 and THF is a suitable solvent for (neutron-irradiated) PLLA. 20 The columns were calibrated using polystyrene standards of known molecular weights (Shodex and Tosoh, Polymer Laboratories).…”

Section: Gel Permeation Chromatography (Gpc)mentioning

confidence: 99%

Holmium-Loaded Poly(l-lactic Acid) Microspheres: In Vitro Degradation Study

et al. 2006

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The clinical application of holmium-loaded poly(L-lactic acid) (PLLA) microspheres for the radionuclide treatment of liver malignancies requires in depth understanding of the degradation characteristics of the microspheres. To this end, an in-vitro degradation study was conducted. PLLA-microspheres with and without HoAcAc loading, and before and after neutron or gamma irradiation, were incubated in a phosphate buffer at 37 degrees C for 12 months. In contrast with the other microsphere formulations, only the neutron-irradiated Ho-PLLA-MS disintegrated. At the end of the experiment (52 weeks) highly crystalline fragments, as evidenced from Differential Scanning Calorimetry, were present. Infrared spectroscopy showed that these fragments consisted of holmium lactate. In conclusion, this study demonstrates that the degradation of neutron-irradiated Ho-PLLA-MS was substantially accelerated by the HoAcAc incorporation and subsequent neutron irradiation. The degradation of these microspheres in aqueous solution resulted in the formation of insoluble holmium lactate microcrystals without release of Ho3+.

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Section: Gel Permeation Chromatography (Gpc)mentioning

confidence: 99%

Holmium-Loaded Poly(l-lactic Acid) Microspheres: In Vitro Degradation Study

et al. 2006

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“…In addition, tumor cells can be continuously exposed throughout the cell cycle to the radiation of radionuclides carried by the microspheres or particles. In recent years, radiolabeled microspheres and particles have been used in clinical settings or animal studies, including 90 Y glass or resin microspheres [2,3], 32 P glass microspheres or colloids [4,5], 166 Ho-loaded glass microparticles [6], 186/188 Re glass microspheres [7] and various biodegradable microspheres, such as 166 Ho poly(L-lactic acid) microspheres(PLLA-MS) [8], and these microspheres and particles showed excellent anti-tumoral effects and a good level of safety after intraarterial or intratumoral injections. There are two forms of commercially available 90 Y microspheres — TheraSphere ® and SIR-Spheres ® — which were approved by the FDA, respectively, in 2000 for use in radiation treatment for inoperable hepatocellular carcinoma and in 2002 for the treatment of colorectal cancer metastasized to the liver [9].…”

Section: Introductionmentioning

confidence: 99%

Interventional therapy for human breast cancer in nude mice with 131I gelatin microspheres (131I-GMSs) following intratumoral injection

Chi

et al. 2014

Radiat Oncol

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IntroductionThe aim of this study was to investigate the effects of 131I gelatin microspheres (131I-GMS) on human breast cancer cells (MCF-7) in nude mice and the biodistribution of 131I-GMSs following intratumoral injections.MethodsA total of 20 tumor-bearing mice were divided into a treatment group and control group and received intratumoral injections of 2.5 mci 131I-GMSs and nonradioactive GMSs, respectively. Tumor size was measured once per week. Another 16 mice received intratumoral injections of 0.4 mci 131I-GMSs and were subjected to single photon emission computed tomography (SPECT) scans and tissue radioactivity concentration measurements on day 1, 4, 8 and 16 postinjection. The 20 tumor-bearing mice received intratumoral injections of 0.4 mci [131I] sodium iodide solution and were subjected to SPECT scans and intratumoral radioactivity measurements at 1, 6, 24, 48 and 72 h postinjection. The tumors were collected for histological examination.ResultsThe average tumor volume in the 131I-GMSs group on post-treatment day 21 decreased to 86.82 ± 63.6%, while it increased to 893.37 ± 158.12% in the control group (P < 0.01 vs. the 131I-GMSs group). 131I-GMSs provided much higher intratumoral retention of radioactivity, resulting in 19.93 ± 5.24% of the injected radioactivity after 16 days, whereas the control group retained only 1.83 ± 0.46% of the injected radioactivity within the tumors at 1 h postinjection.Conclusions131I-GMSs suppressed the growth of MCF-7 in nude mice and provided sustained intratumoral radioactivity retention. The results suggest the potential of 131I-GMSs for clinical applications in radiotherapy for breast cancer.

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“…The modified particles were radiolabeled with rhenium-188 for biomagnetically targeted therapy. Previously, Häfeli et al [90,91,136] demonstrated this technique in both animal and cell culture studies using yttrium-90 and rhenium-188.…”

Section: Active Targeting Radioactive Nanoparticlesmentioning

confidence: 99%

“…The specific activity was 0.1 mCi 188 ReO 4 − per 5 mg of NPs; the best labeling condition was optimized in a volume of 100 L for 50 min at 37 • C. The labeling efficiency was about 90% and the stability of the product in serum albumin was 80% after 10 h. In vitro results showed that 188 Re-labeled particles killed SMMC-7721 cells effectively [136].…”

Section: Active Targeting Radioactive Nanoparticlesmentioning

confidence: 99%

Radioimmunonanoparticles for Cancer Imaging and Therapy

Natarajan

2011

Nanoplatform‐Based Molecular Imaging

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Stability of biodegradable radioactive rhenium (Re-186 and Re-188) microspheres after neutron-activation

Cited by 40 publications

References 29 publications

Holmium-Loaded Poly(l-lactic Acid) Microspheres: In Vitro Degradation Study

Holmium-Loaded Poly(l-lactic Acid) Microspheres: In Vitro Degradation Study

Interventional therapy for human breast cancer in nude mice with 131I gelatin microspheres (131I-GMSs) following intratumoral injection

Radioimmunonanoparticles for Cancer Imaging and Therapy

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