Stability of Aspartame in Water:Organic Solvent Mixtures with Different Dielectric Constants

Sanyude, Sanyude; Locock, R.A.; Pagliaro, Louis A.

doi:10.1002/jps.2600800713

Cited by 22 publications

(11 citation statements)

References 5 publications

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“…Dielectric constant measurements are also essential for understanding the results obtained from remote radar sensing experiments [1]. In pharmaceutical and analytical sciences, the dielectric constant of mixed solvents is required to predict the solubility and chemical stability of a drug [2,3].…”

Section: Introductionmentioning

confidence: 99%

A Simple Method for Estimation of Dielectric Constants and Polarizabilities of Nonpolar and Slightly Polar Hydrocarbons

et al. 2016

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Many of the liquids that are used as electrical insulators are nonpolar or slightly polar petroleum-derived hydrocarbons, such as the ones used for cable and/or transformer oils. In this work, semi-empirical expressions with no adjustable parameters for the dielectric constant and the polarizability of nonpolar and slightly polar hydrocarbons and their mixtures are proposed and validated. The expressions that were derived using the Vargas-Chapman One-Third rule require the mass density and the molecular weight of the substance of interest. The equations were successfully tested for various hydrocarbons and polymers with dipole moments <0.23 and densities from 500 to 1200 kg·m −3 . The predictions are in good agreement with the experimental data in a wide range of temperatures and pressures. The proposed expressions eliminate the need of extensive experimental data and require less input parameters compared to existing correlations.

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Section: Introductionmentioning

confidence: 99%

A Simple Method for Estimation of Dielectric Constants and Polarizabilities of Nonpolar and Slightly Polar Hydrocarbons

et al. 2016

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“…The knowledge of dielectric constant of mixed solvents is required to predict the drug's solubility and chemical stability in a water-cosolvent mixture and the analyte behaviour in analytical methods (Abolghasem et al, 2004). Drug solubility in mixed solvents (Dumanovic et al, 1992), acid dissociation constants of drugs (Newton et al, 1982) and chemical stability of pharmaceuticals (Sanyude et al, 1991) could be explained considering dielectric constant of the solvent system. So far no systematic report has appeared on studies speciation of 2,3-DHBA with some biologically important metal ions in 1, 2-propanediol (propylene glycol, PG)-water mixtures of various concentrations.…”

Section: Introductionmentioning

confidence: 99%

Chemical speciation of 2,3-dihydroxybenzoic acid complexes with some biologically essential metal ions in 1, 2-propanediol–water mixtures

Hirpaye

Rao

2013

Chemical Speciation & Bioavailability

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Chemical speciation of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 2,3-dihydroxybenzoic acid in 0.0-60.0% v/v 1, 2-propanediol-water mixtures maintaining an ionic strength of 0.16 mol dm -3 at 303±0.1 K has been studied pH metrically. The predominant complexes formed are ML, ML 2 and ML 2 H 2 for Co(II), Ni(II) and Zn(II) and ML, ML 2 , ML 2 H and ML 2 H 2 for Cu(II). Models containing different numbers of species were refined by using the computer program MINIQUAD75. Selection of the best fit chemical models was based on statistical parameters and residual analysis. The trend in variation of complex stability constants with dielectric constant of the medium is explained on the basis of electrostatic and non-electrostatic forces. Distributions of species, formation equilibria and effect of influential parameters on the stability constants have been presented. The possible structures of the various species are elucidated on the basis of the analysis of the pH-metric data.

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“…The figure below shows the pH-rate profile for the degradation of aspartame at 60 C in water and aqueous ethanol solutions [15]. Describe the effect of the medium dielectric constant on the degradation.…”

Section: Example 216: Degradation Of Aspartamementioning

confidence: 99%

Principles of Drug Degradation

Loftsson¹

2014

Drug Stability for Pharmaceutical Scientists

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Stability of Aspartame in Water:Organic Solvent Mixtures with Different Dielectric Constants

Cited by 22 publications

References 5 publications

A Simple Method for Estimation of Dielectric Constants and Polarizabilities of Nonpolar and Slightly Polar Hydrocarbons

A Simple Method for Estimation of Dielectric Constants and Polarizabilities of Nonpolar and Slightly Polar Hydrocarbons

Chemical speciation of 2,3-dihydroxybenzoic acid complexes with some biologically essential metal ions in 1, 2-propanediol–water mixtures

Principles of Drug Degradation

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