2007
DOI: 10.1007/s11095-007-9274-8
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Stability of Antimicrobial Decapeptide (KSL) and Its Analogues for Delivery in the Oral Cavity

Abstract: This study suggests that KSL-W could be used as an antiplaque agent in a chewing gum formulation.

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Cited by 48 publications
(49 citation statements)
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“…They form a chemical barrier to protect the host from bacterial, fungal and viral pathogens, help to control the growth of oral biofilms and may help to reduce the occurrence of dental caries and periodontal disease [12]. Previous studies have shown that KSL can effectively inhibit the growth of several bacterial strains [21,26]. In this study, we tested the antimicrobial activity of KSL against a panel of major oral pathogenic bacteria and fungi.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…They form a chemical barrier to protect the host from bacterial, fungal and viral pathogens, help to control the growth of oral biofilms and may help to reduce the occurrence of dental caries and periodontal disease [12]. Previous studies have shown that KSL can effectively inhibit the growth of several bacterial strains [21,26]. In this study, we tested the antimicrobial activity of KSL against a panel of major oral pathogenic bacteria and fungi.…”
Section: Discussionmentioning
confidence: 99%
“…In vitro toxicity studies showed that KSL did not induce cell death or compromise the membrane integrity of human gingival fibroblasts [8]. In addition, KSL and its analogue KSL-W possess the stability, adsorption and release characteristics necessary for local delivery to the oral cavity in a chewing gum formulation, thereby serving as a practically useful antiplaque agent [19][20][21]. As mentioned above, previous studies demonstrated that KSL inhibited selected oral and non-oral pathogens as well as oral biofilms [4,18].…”
Section: Introductionmentioning
confidence: 94%
“…Another promising anticaries AMP is a synthetic α-helical antimicrobial decapeptide designated KSL-W, which can selectively destabilize the cell membranes of cariogenic bacteria including S. mutans, S. sobrinus, and L. acidophilus [Na et al, 2007;Leung et al, 2009]. This peptide resits enzymatic degradation in human saliva for 1 h, and the potential use of KSL-W as an antibiofilm agent in a chewing gum formulation has been suggested Na et al, 2007].…”
Section: Ecological Approaches To Caries Preventionmentioning
confidence: 99%
“…This peptide resits enzymatic degradation in human saliva for 1 h, and the potential use of KSL-W as an antibiofilm agent in a chewing gum formulation has been suggested Na et al, 2007]. More recently, a hydroxyapatite-binding AMP was designed, based on the fusion of specific hydroxyapatite-binding heptapeptide (HBP7) with KSL-W, and this bioconjugate was shown to have improved oral retention and antibacterial efficacy [Huang et al, 2016b].…”
Section: Ecological Approaches To Caries Preventionmentioning
confidence: 99%
“…The stability of GH12 in human saliva was analyzed by reversed-phase HPLC as described [Na et al, 2007], with some modifications. Whole human saliva was collected from 3 healthy volunteers and immediately centrifuged at 4,200 g for 20 min at 4 ° C, and the supernatant was filtered through a 0.22-μm syringe filter.…”
Section: Secondary Structure and Stability Of Gh12mentioning
confidence: 99%