Stability of Antibiotics in Portable Pumps Used for Bronchial Superinfection: Guidelines for Prescribers

Arlicot, Nicolas; Rochefort, Gaël Y.; Schlecht, Deborah; Lamoureux, Fabien; Marchand, Sophie; Antier, Daniel

doi:10.1542/peds.2007-0630

Cited by 25 publications

(22 citation statements)

References 17 publications

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“…Results from this study were focused on applications in orthopaedics, but may also find applications in other clinical settings wherein antibiotic stability is also an issue, such as administration of antibiotics by continuous infusion or via portable elastomeric pumps for parenteral outpatient treatment. 11-16,21 The latter example certainly is an issue since portable devices might reach temperatures of up to 35°C under real-life conditions. 21 …”

Section: Discussionmentioning

confidence: 99%

“…11-16,21 The latter example certainly is an issue since portable devices might reach temperatures of up to 35°C under real-life conditions. 21 …”

Section: Discussionmentioning

confidence: 99%

“…Not unexpectedly, beta-lactam antibiotics were found to be almost completely degraded over time, with the exception of the monobactam aztreonam, which apparently has a higher stability. 16,21,22 Some beta-lactams, namely flucloxacillin, ticarcillin with clavulanate, piperacillin with tazobactam, cefazolin and ceftriaxone, maintained relevant antibacterial activity for up to 21 days. The greater inhibition zones observed in the bioassays for the combination of amoxicillin with clavulanate, compared with amoxicillin alone, might be explained by a synergistic antibacterial effect of the combination.…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement

Samara

Moriarty

Décosterd

et al. 2017

Bone & Joint Research

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ObjectivesThermal stability is a key property in determining the suitability of an antibiotic agent for local application in the treatment of orthopaedic infections. Despite the fact that long-term therapy is a stated goal of novel local delivery carriers, data describing thermal stability over a long period are scarce, and studies that avoid interference from specific carrier materials are absent from the orthopaedic literature.MethodsIn this study, a total of 38 frequently used antibiotic agents were maintained at 37°C in saline solution, and degradation and antibacterial activity assessed over six weeks. The impact of an initial supplementary heat exposure mimicking exothermically curing bone cement was also tested as this material is commonly used as a local delivery vehicle. Antibiotic degradation was assessed by liquid chromatography coupled to mass spectrometry, or by immunoassays, as appropriate. Antibacterial activity over time was determined by the Kirby-Bauer disk diffusion assay.ResultsThe heat exposure mimicking curing bone cement had minimal effect on stability for most antibiotics, except for gentamicin which experienced approximately 25% degradation as measured by immunoassay. Beta-lactam antibiotics were found to degrade quite rapidly at 37°C regardless of whether there was an initial heat exposure. Excellent long-term stability was observed for aminoglycosides, glycopeptides, tetracyclines and quinolones under both conditions.ConclusionsThis study provides a valuable dataset for orthopaedic surgeons considering local application of antibiotics, and for material scientists looking to develop next-generation controlled or extended-release antibiotic carriers.Cite this article: E. Samara, T. F. Moriarty, L. A. Decosterd, R. G. Richards, E. Gautier, P. Wahl. Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement. Bone Joint J 2017;6:296–306. DOI: 10.1302/2046-3758.65.BJR-2017-0276.R1.

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Section: Discussionmentioning

confidence: 99%

“…11-16,21 The latter example certainly is an issue since portable devices might reach temperatures of up to 35°C under real-life conditions. 21 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement

Samara

Moriarty

Décosterd

et al. 2017

Bone & Joint Research

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“…Ticarcillin disodium (∼ 55% R and ∼ 45% S isomers; internal standard, IS) was from Sigma-Aldrich Inc. (St. Louis, MO, USA). Both molecules are chemically stable for at least 24 h at 37°C [9,10] and much longer at 4°C [11,12]. HPLC/MSgrade methanol and acetonitrile were purchased from J.T.…”

Section: Methodsmentioning

confidence: 99%

Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum

Pokem

Bastos

Tulkens

et al. 2015

Clinical Biochemistry

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Objectives: The aim of this study was to develop and validate a HPLC-MS/MS assay to determine total and unbound concentrations of temocillin in serum samples.Design and methods: Methanolic protein precipitation and ultrafiltration were used for total and unbound concentration extraction, respectively. Extract was injected into a LC-MS/MS system. Reversed phase chromatography was performed on a phenyl grafted column in gradient mode. Temocillin and internal standard (ticarcillin) were identified in positive electrospray ionization mode using ion transitions of m/z 415.34 N 339.1 and 385.31 N 160.3, respectively.Results: Temocillin total and unbound concentration quantification assays were linear over concentrations ranging from 1 to 500 mg/L and from 0.5 to 300 mg/L, respectively. Both assays presented acceptable intra and inter-assay precision and accuracy b 13.9%. Limits of quantification and detection were of 1 and 0.10 mg/L, and 0.5 and 0.05 mg/L for total and unbound concentration respectively. Total temocillin concentration recovery ranged from 85.80 to 99.40%. Temocillin ion suppression effect was b36.2 % in both assays. Conclusion: The method described is fast, sensitive and selective, with no interferences. This method may be used for both pharmacokinetic studies and therapeutic drug monitoring purposes.

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“…Les choses sont sensiblement plus complexes que cet énoncé brut des résultats dans la mesure où les auteurs constatent une forte influence de la concentration de l'antibiotique sur l'importance de la dégradation. Vraisemblablement, la concentration influence directement le pH qui est le facteur clef de la stabilité [26,[34][35][36][37][38][39][40][41][42][43][44].…”

Section: Inconvénients Liés à La Perfusion Continueunclassified

Perfusion continue des bêtalactamines : intérêts, inconvénients, modalités pratiques

Jehl

Levêque

2009

Réanimation

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Stability of Antibiotics in Portable Pumps Used for Bronchial Superinfection: Guidelines for Prescribers

Cited by 25 publications

References 17 publications

Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement

Antibiotic stability over six weeks in aqueous solution at body temperature with and without heat treatment that mimics the curing of bone cement

Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum

Perfusion continue des bêtalactamines : intérêts, inconvénients, modalités pratiques

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