Stability of antibacterial and coccidiostat drugs on chicken meat burgers upon cooking and in vitro digestion

Sobral, M. Madalena C.; Romero‐González, Roberto; Faria, Miguel A.; Cunha, Sara C.; Ferreira, Isabel M. P. L. V. O.; Garrido-Frenich, Antonia

doi:10.1016/j.foodchem.2020.126367

Cited by 16 publications

(11 citation statements)

References 40 publications

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“…The persistent occurrences of chemical residues in food of animal origin, including poultry meat and eggs is a matter of major concern for consumers’ health ( Mund et al, 2017 ; Roila et al, 2019 ; Sobral et al, 2020 ). Consumption of eggs contaminated with chemical residues can lead to side effects such as allergic reactions, drug-drug interactions, and disruption in gut normal flora ( Beyene, 2016 ; Mund et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Ionophore coccidiostats – disposition kinetics in laying hens and residues transfer to eggs

Bello¹,

Henri²,

Viel³

et al. 2023

Poultry Science

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Section: Introductionmentioning

confidence: 99%

Ionophore coccidiostats – disposition kinetics in laying hens and residues transfer to eggs

Bello¹,

Henri²,

Viel³

et al. 2023

Poultry Science

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“…Despite the notification that the ingestion of pure molecules caused acute toxicity in humans, the primary concerns are the chronic toxicity related to long term exposition, which can cause hypersensitive reactions due to the unbalance of the dynamics in the gastrointestinal flora, and changing the microflora of the gut to develop microbial resistance to antibiotics [ 58 ].…”

Section: Legislationmentioning

confidence: 99%

Coccidiostats and Poultry: A Comprehensive Review and Current Legislation

Martins

Silva

Pereira

et al. 2022

Foods

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Coccidiosis remains one of the major problems of the poultry industry. Caused by Eimeria species, Coccidiosis is a contagious parasitic disease affecting poultry with great economic significance. Currently, in order to prevent health problems caused by this disease, broiler farmers make extensive use of coccidiostats in poultry feed, maintaining animal health and, in some cases, enhancing feed conversion. The presence of unauthorized substances, residues of veterinary products and chemical contaminants in the food industry is of concern, since they may pose a risk to public health. As the use of coccidiostats has been increasing without any requirements for veterinary prescription, research and surveillance of coccidiostat residues in poultry meat is becoming imperative. This review presents an up-to-date comprehensive discussion of the state of the art regarding coccidiosis, the most used anticoccidials in poultry production, their mode of action, their prophylactic use, occurrence and the European Union (EU) applicable legislation.

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“…To our knowledge, no study of the stability of antibiotics in blood serum has been previously reported. However, the stability of antibiotics in meat can indeed be low in some cases [7,33,34] and could thus compromise confirmatory analysis results. Confirmation of presumptive positive results should therefore be carried out as soon as possible after screening, as certain storage conditions such as freezing temperature, time of storing and sample preparation may have an impact on antimicrobial stability [33].…”

Section: Validation With Blood Samples Injected In Vivomentioning

confidence: 99%

Optimization and Validation of a New Microbial Inhibition Test for the Detection of Antimicrobial Residues in Living Animals Intended for Human Consumption

Serrano

Mata²,

García-Gonzalo

et al. 2021

Foods

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Even though antibiotics are necessary in livestock production, they can be harmful not only due to their toxicity, but also in view of their contribution to the emergence of antimicrobial resistance. Screening tests based on microbial growth inhibition appeared to be useful tools to prevent its entry into the food chain. They have nevertheless been traditionally carried out post mortem, leading to great economical loss and harm to the environment in case a positive sample is found. Hence, the objective was to evaluate the use of a screening test as an ante mortem alternative for the detection of antibiotic residues in meat: thus, Explorer®-Blood test was optimized and validated. After adapting the procedure for matrix preparation, the assay parameters were assessed from 344 antibiotic-free blood serum samples. Limits of Detection (LoDs) were defined by spiking blood serum with several of the most common antimicrobials used in veterinary practice. LoDs were similar to those obtained for meat and were at or below the maximum residue limits set by EU legislation for muscle. Analyses of in vivo injected samples, previously characterized by LC-MS/MS, demonstrated the method’s accuracy and proved that Explorer®-Blood can be considered a suitable alternative to conventional post mortem screening methods.

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Stability of antibacterial and coccidiostat drugs on chicken meat burgers upon cooking and in vitro digestion

Cited by 16 publications

References 40 publications

Ionophore coccidiostats – disposition kinetics in laying hens and residues transfer to eggs

Ionophore coccidiostats – disposition kinetics in laying hens and residues transfer to eggs

Coccidiostats and Poultry: A Comprehensive Review and Current Legislation

Optimization and Validation of a New Microbial Inhibition Test for the Detection of Antimicrobial Residues in Living Animals Intended for Human Consumption

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